Toothache (DBCOND0001908)

Identifiers

Synonyms

Toothaches / Odontalgia / Other specified disorders of teeth and supporting structures / Toothache (finding) / Tooth ache / Tooth pain

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetaminophen	An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Cytochrome P450 1A2enzyme Cytochrome P450 2E1enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2D6enzyme Cytochrome P450 2A6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B15enzyme Sulfotransferase 1A1enzyme Sulfotransferase 1A3enzyme Arylamine N-acetyltransferase 2enzyme Prostaglandin E synthase 3target Transient receptor potential cation channel subfamily V member 1target Albumincarrier Fatty-acid amide hydrolase 1enzyme Glutathione S-transferase Penzyme Glutathione S-transferase Mu 1enzyme Sodium-dependent noradrenaline transportertarget Sodium-dependent serotonin transportertarget
Acetylsalicylic acid	A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Aldo-keto reductase family 1 member C1target Solute carrier family 22 member 6transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme 5'-AMP-activated protein kinasetarget Endothelin-1 receptortarget Cellular tumor antigen p53target Endoplasmic reticulum chaperone BiPtarget Ribosomal protein S6 kinase alpha-3target NF-kappa-B inhibitor alphatarget Tumor necrosis factor-inducible gene 6 proteintarget Caspase-1target Caspase-3target Inhibitor of nuclear factor kappa-B kinase subunit betatarget Extracellular signal-regulated kinase (ERK)target G1/S-specific cyclin-D1target Myc proto-oncogene proteintarget Proliferating cell nuclear antigentarget Cyclin Atarget UDP-glucuronosyltransferase 1-6enzyme Arylamine N-acetyltransferase 2enzyme Organic anion transporter 3transporter Sialidase-1target 3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
Caffeine	A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.	Adenosine receptor A1target 3',5'-cyclic-AMP phosphodiesterase 4Btarget Adenosine receptor A2atarget Cytochrome P450 1A2enzyme Ryanodine receptor 1target Cytochrome P450 3A4enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2D6enzyme Cyclic nucleotide phosphodiesterasetarget DNA-dependent protein kinase catalytic subunittarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget Inositol 1,4,5-trisphosphate receptortarget Serine-protein kinase ATMtarget Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Adenosine receptor A2btarget Adenosine receptor A3target Phosphodiesterase enzymestarget 5'-nucleotidasetarget
Carbaspirin calcium	An NSAID indicated in the treatment of short term pain and fever.	No drug targets
Clove oil	Clove oil is primarily indicated in conditions like colic, flatulence, and toothache .	Vascular cell adhesion protein 1target C-X-C motif chemokine 10target Collagen alpha-1(I) chaintarget Granulocyte-macrophage colony-stimulating factor receptor subunit alphatarget
Naproxen	An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Albumincarrier Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Solute carrier organic anion transporter family member 1A2transporter Solute carrier family 22 member 6transporter Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 2B7enzyme Peptostreptococcal albumin-binding proteintarget Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1-6enzyme UDP-glucuronosyltransferase 1A7enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 1A10enzyme Organic anion transporter 3transporter Pancreatic triacylglycerol lipasetarget
Propyphenazone	Not Annotated	No drug targets
Pyridoxine	A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.	Pyridoxal kinasetarget Cytochrome P450 1A1enzyme Albumincarrier Pyridoxal kinaseenzyme Chronophinenzyme Alkaline phosphatase, tissue-nonspecific isozymetransporter Alkaline phosphatase, tissue-nonspecific isozymeenzyme Aromatic-L-amino-acid decarboxylasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03472456	Endodontic Medications for Irreversible Pulpitis: Articaine or Eugenol?	Eugenol	Not Available	Not Available	completed
NCT00115102	Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls	Esketamine Fentanyl	diagnostic	4	completed
NCT06330207	An Emergency Department (ED) Provider Centered Intervention for Non-Traumatic Dental Condition Management (NTDC)	No drug interventions	health_services_research	Not Available	not_yet_recruiting
NCT03413475	Oral Quality of Life	No drug interventions	Not Available	Not Available	completed
NCT01982799	Local Anesthesia and Analgesics in Endodontic Pain	Acetaminophen Hydrocodone Ibuprofen Naproxen	supportive_care	Not Available	withdrawn
NCT04642404	CBD for Dental Pain	Cannabidiol	treatment	1 / 2	completed
NCT00574015	The Comparison of Supraperiosteal Nerve Block With Opiate Analgesia in Alleviating the Pain of Toothache	Acetaminophen Bupivacaine Hydrocodone	treatment	4	completed
NCT02463552	Naproxen on Tooth Sensitivity Caused by In-office Bleaching	Naproxen	prevention	Not Available	completed
NCT03153657	Piroxicam-beta-Cyclodextrin on Tooth Sensitivity Caused by In-office Bleaching	Piroxicam	prevention	3	completed
NCT02862691	Percocet vs. Bupivicaine for Toothaches in the ED	Acetaminophen Oxycodone	treatment	2	terminated
NCT00281684	SB-705498 Dental Pain Study After Tooth Extraction	Acetaminophen Codeine	treatment	2	completed
NCT06216951	Post-Operative Pain After Vital Pulpotomy in Molars With Symptomatic Pulpitis	No drug interventions	Not Available	Not Available	completed
NCT02630771	Multimodal Assessment of Sensory Processing and Brain Features in Patients With Chronic Orofacial Pain	No drug interventions	Not Available	Not Available	completed
NCT00474175	Benzocaine Gel Toothache Dose-Response Study	Benzocaine	treatment	4	completed
NCT00720057	Assessing the Analgesic Efficacy of Naproxen Sodium in Postsurgical Dental Pain.	Naproxen	treatment	3	completed
NCT06510244	Pain Perception Measurement by EEG and NRS	No drug interventions	Not Available	Not Available	recruiting