This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Propyphenazone
- DrugBank Accession Number
- DB13524
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Propyphenazone (DB13524)
- Weight
- Average: 230.311
Monoisotopic: 230.141913208 - Chemical Formula
- C14H18N2O
- Synonyms
- 1-Phenyl-2,3-dimethyl-4-isopropyl-3-pyrazolin-5-one
- 1-Phenyl-2,3-dimethyl-4-isopropylpyrazol-5-one
- 4-Isopropyl-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one
- 4-Isopropylantipyrine
- Isopropylantipyrine
- Isopropylphenazone
- Propifenazona
- Propyphenazone
- Propyphenazonum
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Propyphenazone may decrease the excretion rate of Abacavir which could result in a higher serum level. Abciximab The risk or severity of bleeding and hemorrhage can be increased when Propyphenazone is combined with Abciximab. Acebutolol Propyphenazone may decrease the antihypertensive activities of Acebutolol. Aceclofenac The risk or severity of adverse effects can be increased when Aceclofenac is combined with Propyphenazone. Acemetacin The risk or severity of adverse effects can be increased when Propyphenazone is combined with Acemetacin. Acenocoumarol The risk or severity of bleeding and hemorrhage can be increased when Propyphenazone is combined with Acenocoumarol. Acetohexamide The protein binding of Acetohexamide can be decreased when combined with Propyphenazone. Acetylsalicylic acid The risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Propyphenazone. Aclidinium Propyphenazone may decrease the excretion rate of Aclidinium which could result in a higher serum level. Acrivastine Propyphenazone may decrease the excretion rate of Acrivastine which could result in a higher serum level. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Yoshipyrin
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Adolomed 250 mg/300 mg/50 mg Tabletten Propyphenazone (250 mg) + Acetaminophen (300 mg) + Caffeine (50 mg) Tablet Oral Kwizda Pharma Gmb H 1986-08-22 Not applicable Austria 
ALJIL 150 MG/300 MG/50 MG TABLET, 20 ADET Propyphenazone (150 mg) + Acetaminophen (300 mg) + Caffeine (50 mg) Tablet Oral RECORDATİ İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey 
BIOPTAN DRAJE, 30 ADET Propyphenazone (250 mg) + Caffeine (50 mg) Tablet, coated Oral BİOFARMA İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey DERMAN 300/100/50 MG KAŞE, 1 KAŞE Propyphenazone (100 mg) + Acetaminophen (300 mg) + Caffeine (50 mg) Powder Oral DERMAN İLAÇ SAN.VE TİC. A.Ş. 2020-08-14 Not applicable Turkey Geworin Propyphenazone (150 mg/1) + Acetaminophen (300 mg/1) + Caffeine (50 mg/1) Tablet Oral OASIS TRADING 2018-11-20 Not applicable US 
Geworin Propyphenazone (150 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Lydia Co., Ltd. 2023-02-11 Not applicable US MİNAMOL PLUS 250MG/150MG/50MG TABLET, 20 ADET Propyphenazone (150 mg) + Acetaminophen (250 mg) + Caffeine (50 mg) Tablet Oral PHARMACTİVE İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey MİNAMOL PLUS 250MG/150MG/50MG TABLET, 30 ADET Propyphenazone (150 mg) + Acetaminophen (250 mg) + Caffeine (50 mg) Tablet Oral PHARMACTİVE İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey MINOSET PLUS 250 MG/150 MG/50 MG TABLET, 20 ADET Propyphenazone (150 mg) + Acetaminophen (250 mg) + Caffeine (50 mg) Tablet Oral BAYER TÜRK KİMYA SAN. LTD. ŞTİ. 2020-08-14 Not applicable Turkey MINOSET PLUS 250 MG/150 MG/50 MG TABLET, 30 ADET Propyphenazone (150 mg) + Acetaminophen (250 mg) + Caffeine (50 mg) Tablet Oral BAYER TÜRK KİMYA SAN. LTD. ŞTİ. 2020-08-14 Not applicable Turkey - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Geworin Propyphenazone (150 mg/1) + Acetaminophen (300 mg/1) Tablet Oral Lydia Co., Ltd. 2023-02-11 Not applicable US PANALGINE TABLET, 30 ADET Propyphenazone (150 mg) + Acetaminophen (300 mg) + Caffeine (30 mg) Tablet Oral ATABAY İLAÇ FABRİKASI A.Ş. 2020-08-14 Not applicable Turkey PAROL PLUS TABLET, 30 ADET Propyphenazone (150 mg) + Acetaminophen (250 mg) + Caffeine (50 mg) Tablet Oral ATABAY KİMYA SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey
Categories
- ATC Codes
- N02BB74 — Propyphenazone, combinations with psycholepticsN02BB54 — Propyphenazone, combinations excl. psycholepticsN02BB04 — Propyphenazone
- Drug Categories
- Agents causing hyperkalemia
- Agents that produce hypertension
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Nephrotoxic agents
- Nervous System
- Non COX-2 selective NSAIDS
- Peripheral Nervous System Agents
- Pyrazoles
- Pyrazolones
- Sensory System Agents
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Azoles
- Sub Class
- Pyrazoles
- Direct Parent
- Phenylpyrazoles
- Alternative Parents
- Pyrazolones / Benzene and substituted derivatives / Vinylogous amides / Heteroaromatic compounds / Lactams / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides show 1 more
- Substituents
- Aromatic heteromonocyclic compound / Azacycle / Benzenoid / Heteroaromatic compound / Hydrocarbon derivative / Lactam / Monocyclic benzene moiety / Organic nitrogen compound / Organic oxide / Organic oxygen compound show 6 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- pyrazolone (CHEBI:135538)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- OED8FV75PY
- CAS number
- 479-92-5
- InChI Key
- PXWLVJLKJGVOKE-UHFFFAOYSA-N
- InChI
- InChI=1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3
- IUPAC Name
- 1,5-dimethyl-2-phenyl-4-(propan-2-yl)-2,3-dihydro-1H-pyrazol-3-one
- SMILES
- CC(C)C1=C(C)N(C)N(C1=O)C1=CC=CC=C1
References
- General References
- TITCK Product Information: Minamol Plus (acetaminophen/caffeine/propyphenazone) oral tablets [Link]
- External Links
- KEGG Drug
- D01380
- ChemSpider
- 3646
- 34710
- ChEBI
- 135538
- ChEMBL
- CHEMBL28318
- ZINC
- ZINC000000049151
- Wikipedia
- Propyphenazone
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Completed Treatment Menstrual Distress (Dysmenorrhea) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule Powder Oral Tablet Oral Suppository Rectal Tablet, coated Oral Tablet, film coated Oral Suppository Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 9.26 mg/mL ALOGPS logP 1.94 ALOGPS logP 2.35 Chemaxon logS -1.4 ALOGPS pKa (Strongest Basic) 0.47 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 23.55 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 69.92 m3·mol-1 Chemaxon Polarizability 26.43 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Drug created at June 23, 2017 20:43 / Updated at September 28, 2021 21:54