Proctitis (DBCOND0011080)

Identifiers

Synonyms

Other specified diseases of anus and rectum / Proctitis (disorder) / Proctitis NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Aluminum subacetate	A medication used to prevent infection and treat irritation around the rectum.	No drug targets
Balsam of Peru	Balsam of Peru is found in diverse cosmetics and perfumes as well as a flavoring agent in cough syrups, lozenges, chewing gum, and candies. As a medical agent, balsam of...	No drug targets
Calcium carbonate	An ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.	No drug targets
Esculin	As medication, esculin is sometimes used as a vasoprotective agent. Esculin is also used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria),...	Glutaminase kidney isoform, mitochondrialenzyme Androgen receptortarget
Fluocortolone caproate	A corticosteroid indicated in the treatment of hemorrhoids, anal fissures, and corticosteroid-responsive dermatoses.	No drug targets
Fluocortolone pivalate	A corticosteroid used to treat corticosteroid-responsive dermatoses and hemorrhoids.	No drug targets
Hydrocortisone	A glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier Organic anion transporter 3transporter Aldo-keto reductase family 1 member D1enzyme 3-oxo-5-alpha-steroid 4-dehydrogenase 2enzyme 11-beta-hydroxysteroid dehydrogenase type 2enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme
Hydrocortisone acetate	A corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses and ulcerative colitis.	Annexin A1target Glucocorticoid receptortarget Sex hormone-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 11B2, mitochondrialenzyme Cytochrome P450 2C8enzyme Corticosteroid-binding globulincarrier 11-beta-hydroxysteroid dehydrogenase type 2target 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target Organic anion transporter 3transporter
Mesalazine	An aminosalicylate drug used to treat mild to moderate active ulcerative colitis and also to maintain remission once achieved.	Prostaglandin G/H synthase 1target Prostaglandin G/H synthase 2target Peroxisome proliferator-activated receptor gammatarget Inhibitor of nuclear factor kappa-B kinase subunit alphatarget Inhibitor of nuclear factor kappa-B kinase subunit betatarget Polyunsaturated fatty acid 5-lipoxygenasetarget Arylamine N-acetyltransferase 1enzyme Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 2B1transporter Nitric oxide synthase, inducibletarget
Oxetacaine	An antacid used to treat gastritis, peptic ulcer disease, heartburn, esophagitis, hiatus hernia, and anorexia.	Cytochrome P450 3A4enzyme Gastrintarget
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Prednisolone caproate	A corticosteroid indicated to treat hemorrhoids, anal fissures, and proctitis.	No drug targets
Sulfasalazine	A salicylate used to treat Crohn's disease, ulcerative colitis, and rheumatoid arthritis.	Acetyl-CoA acetyltransferase, mitochondrialtarget Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-binding cassette sub-family C member 2transporter Prostaglandin G/H synthase 2target Prostaglandin G/H synthase 1target Polyunsaturated fatty acid 5-lipoxygenasetarget Proton-coupled folate transportertransporter Phospholipase A2target Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 2B1transporter Albumincarrier Cystine/glutamate transportertarget Nuclear factor NF-kappa-B p105 subunittarget Nuclear factor NF-kappa-B p100 subunittarget Inhibitor of nuclear factor kappa-B kinase subunit betatarget Inhibitor of nuclear factor kappa-B kinase subunit alphatarget Peroxisome proliferator-activated receptor gammatarget Hepatic sodium/bile acid cotransportertransporter Broad substrate specificity ATP-binding cassette transporter ABCG2target Transcription factor p65target Proto-oncogene c-Reltarget Transcription factor RelBtarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01837615	Assessment of Photopill Capsule Treatment for Safety and Feasibility in Ulcerative Proctitis	No drug interventions	treatment	2	completed
NCT01349673	The Safety and Tolerability of Budesonide Foam in Participants With Active Ulcerative Proctitis or Proctosigmoiditis	Budesonide	treatment	3	terminated
NCT01172444	Clinical Trial With Mesalamine 1g Suppositories	Mesalazine	treatment	3	terminated
NCT01008423	Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis	Budesonide	treatment	3	completed
NCT01966783	Budesonide vs. Mesalazine vs. Budesonide/Mesalazine Suppository Combination Therapy in Acute Ulcerative Proctitis	Budesonide Mesalazine	treatment	2	completed
NCT01008410	Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis	Budesonide	treatment	3	completed