Pyelonephritis (DBCOND0014040)

Identifiers

Synonyms

Pyelonephritis NOS / Interstitial nephritis NOS / Pyelonephritis (disorder) / Pyelonephritis, unspecified / Renal tubulo-interstitial disease, unspecified / Tubulointerstitial nephritis (disorder) / Tubulointerstitial nephritis / Nephritis, Tubulointerstitial

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cefepime	A fourth-generation cephalosporin antibiotic used in the treatment of infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections.	Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Penicillin-binding protein 2target Peptidoglycan synthase FtsItarget Cell division proteintarget Penicillin-binding protein 2target Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 1Btarget
Cefiderocol	A cephalosporin antibiotic used in complicated urinary tract infections.	Cell division proteintarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target D-alanyl-D-alanine carboxypeptidase DacBtarget MexAB-OprM efflux systemtransporter Albumincarrier Catecholate siderophore receptor Fiutransporter Colicin I receptortransporter Putative outer membrane ferric siderophore receptortransporter
Cilastatin	A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.	Dipeptidase 1target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Doripenem	An antibiotic of the penem class used to treat complicated intra-abdominal and urinary tract infections.	Dipeptidase 1enzyme Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Cell division proteintarget Penicillin-binding protein 4target Organic anion transporter 3transporter Dihydropteroate synthasetarget
Escherichia coli	A probiotic indicated to treat urinary tract infections and irritable bowel syndrome.	No drug targets
Imipenem	A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Penicillin-binding protein 3target Dipeptidase 1enzyme Penicillin-binding protein 4target Beta-lactamase SHV-1enzyme Beta-lactamase TEMenzyme Beta-lactamase CTX-Menzyme Beta-lactamaseenzyme Beta-lactamasetarget
Norfloxacin	A broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 6transporter Cytochrome P450 1A1enzyme Cytochrome P450 3A7enzyme DNA gyrase subunit Atarget DNA topoisomerase 2target DNA topoisomerase 4 subunit Atarget DNA gyrase subunit Btarget
Plazomicin	An aminoglycoside antibiotic used to treat complicated urinary tract infections.	Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter 30S ribosomal protein S14target 30S ribosomal protein S11target rRNA methyltransferase 2, mitochondrialtarget
Relebactam	A beta-lactamase inhibitor used to prevent hydrolysis of beta-lactam antibiotics, leading to increased effectiveness.	Organic anion transporter 3transporter Solute carrier family 22 member 11transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Beta-lactamase TEMtarget Beta-lactamase SHV-1target Beta-lactamase CTX-Mtarget Beta-lactamasetarget Beta-lactamasetarget Beta-lactamasetarget
Tazobactam	A beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy.	Beta-lactamase TEMtarget Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Beta-lactamase Ohio-1target Beta-lactamase SHV-1target Beta-lactamasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00229021	Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis	No drug interventions	treatment	3	completed
NCT06526884	Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)	No drug interventions	health_services_research	Not Available	recruiting
NCT00948779	Antibiotic Education for Children in an Emergency Care Unit	No drug interventions	supportive_care	Not Available	completed
NCT02246361	Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication	No drug interventions	supportive_care	4	completed
NCT00724256	Short-term Antibiotic Therapy for Pyelonephritis in Childhood	Ceftibuten	treatment	3	terminated
NCT01628900	Prospective Study in the Emergency	No drug interventions	diagnostic	2	terminated
NCT03282006	Treating Pyelonephritis an Urosepsis With Pivmecillinam	Amdinocillin Pivmecillinam	treatment	4	completed
NCT03959163	The Validity of the Quick Renal MRI in Pediatric Kidney Disease	No drug interventions	diagnostic	Not Available	recruiting
NCT00210886	A Comparison of the Effectiveness and Safety of Levofloxacin to That of Ciprofloxacin in Treating Complicated Urinary Tract Infection and Acute Pyelonephritis.	Levofloxacin	treatment	3	completed
NCT00528476	Risk Factors for Recurrent Urinary Tract Infection in Children	No drug interventions	Not Available	Not Available	completed
NCT02598362	Pharmacokinetics of Ciprofloxacin in Pediatric Patients	Ciprofloxacin	treatment	4	completed
NCT01345929	Study Comparing the Safety and Efficacy of Intravenous CXA-201 and Intravenous Levofloxacin in Complicated Urinary Tract Infection, Including Pyelonephritis	Levofloxacin	treatment	3	completed
NCT01641029	Community-Associated Uropathogen Antimicrobial Resistance Among Emergency Department Patients With Acute Pyelonephritis	No drug interventions	Not Available	Not Available	completed
NCT00258089	A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in the Treatment of Complicated Urinary Tract Infections	Levofloxacin	treatment	3	completed
NCT03873701	Bedside Ultrasonography in Acute Patients With Suspected Kidney Involvement	No drug interventions	Not Available	Not Available	completed
NCT00805181	Kinetics of Biomarkers in Acute Pyelonephritis	No drug interventions	Not Available	Not Available	completed
NCT03275623	Management of Sub-Clinical Bacteriuria in Pregnancy	No drug interventions	treatment	4	completed
NCT03230838	MK-7625A Versus Meropenem in Pediatric Participants With Complicated Urinary Tract Infection (cUTI) (MK-7625A-034)	Ceftolozane Meropenem Tazobactam	treatment	2	completed
NCT00382343	A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux	Sulfamethoxazole Trimethoprim	prevention	4	completed
NCT00210990	Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis	Doripenem	treatment	3	completed
NCT01861353	Cranberry-lingonberry Juice Started During Acute Infection in Prevention of Urinary Tract Infections in Children	No drug interventions	prevention	Not Available	completed
NCT04594161	Effectiveness of Drainage by PCN vs. JJ in Patients With Symptoms of Obstructive Kidney Disease Caused by Urolithiasis	No drug interventions	other	Not Available	completed
NCT00136656	Treatment of Acute Pyelonephritis With Gram Negative Strains in Infants and Children Less Than 3 Years Old	No drug interventions	treatment	4	completed
NCT06299215	Factors and Prognosis of Obstructive Pyelonephritis Patients	No drug interventions	Not Available	Not Available	recruiting
NCT01771432	Antibiotic Treatment Versus no Therapy in Kidney Transplant Recipients With Asymptomatic Bacteriuria	No drug interventions	prevention	Not Available	unknown_status
NCT00752375	Antibiotic Prophylaxis in Children With Pyelonephritis	Sulfamethoxazole Trimethoprim	treatment	3	withdrawn
NCT06128213	NRX-101 for Complicated Urinary Tract Infection (UTI) Including Pyelonephritis	Cycloserine Lurasidone Nitrazepam	treatment	2	not_yet_recruiting
NCT01505634	Safety, Tolerability, and Efficacy of MK-7655 (Relebactam) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone for Treating Complicated Urinary Tract Infection (cUTI) (MK-7655-003)	Cilastatin Ciprofloxacin Imipenem Relebactam	treatment	2	completed
NCT02080182	Effect of Acetylcysteine in Pediatric Acute Pyelonephritis.	Acetylcysteine	treatment	2	completed
NCT02728089	Study of Ceftolozane/Tazobactam (MK-7625A) in Japanese Participants With Uncomplicated Pyelonephritis and Complicated Urinary Tract Infection (MK-7625A-014)	Ceftolozane Tazobactam	treatment	3	completed
NCT00190281	Contrast-Enhanced US of Spleen, Liver and Kidney	No drug interventions	Not Available	Not Available	unknown_status
NCT01476995	Prognostic Indicators as Provided by the EPIC ClearView	No drug interventions	Not Available	Not Available	completed