Bronchoconstriction (DBCOND0020847)

Identifiers

Synonyms

Spasm bronchial / Bronchial Spasm / Bronchospasm (finding) / Bronchospasm / Bronchospasm NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Albuterol	A beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise induced bronchospasms.	Beta-2 adrenergic receptortarget Beta-1 adrenergic receptortarget Cytochrome P450 3A4enzyme Beta-3 adrenergic receptortarget
Arformoterol	A beta-2 adrenergic agonist and bronchodilator used for long-term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.	Beta-2 adrenergic receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2C9enzyme
Budesonide	A corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Bile salt export pumptransporter ATP-dependent translocase ABCB1transporter Annexin A1target Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Corticosteroid-binding globulincarrier Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Albumincarrier
Carmoterol	A long acting beta-2 agonist indicated in the treatment of COPD, asthma, and chronic bronchitis.	Beta-2 adrenergic receptortarget
Ciclesonide	A glucocorticoid used in the symptomatic relief of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme Glucocorticoid receptortarget Liver carboxylesterase 1enzyme Corticosteroid-binding globulintarget
Formoterol	An inhaled long-acting beta2-adrenergic receptor agonist used as a bronchodilator in the management of asthma and COPD.	Beta-2 adrenergic receptortarget Beta-1 adrenergic receptortarget Beta-3 adrenergic receptortarget Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2A6enzyme UDP-glucuronosyltransferase 1A8enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme Solute carrier family 22 member 1transporter Solute carrier family 22 member 4transporter Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 3transporter Albumincarrier UDP-glucuronosyltransferase 1A1enzyme
Oxtriphylline	A bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema.	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3Atarget 3',5'-cyclic-AMP phosphodiesterase 4Atarget Adenosine receptor A2atarget Adenosine receptor A1target Cytochrome P450 1A2enzyme Solute carrier family 22 member 7transporter Histone deacetylase 2target
Theophylline	A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction.	cGMP-inhibited 3',5'-cyclic phosphodiesterase 3Atarget 3',5'-cyclic-AMP phosphodiesterase 4Btarget Adenosine receptor A2btarget 3',5'-cyclic-AMP phosphodiesterase 4Atarget cGMP-specific 3',5'-cyclic phosphodiesterasetarget Adenosine receptor A1target Adenosine receptor A2atarget Cytochrome P450 1A2enzyme Adenosine deaminaseenzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Solute carrier family 22 member 7transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2D6enzyme Histone deacetylase 2target Copine-1target Minor histocompatibility antigen H13target BOS complex subunit NOMO1target Poly [ADP-ribose] polymerase 1target Protein RIC-3target Tubulin monoglycylase TTLL3target 5'-nucleotidasetarget
Tiotropium	A long-acting bronchodilator used in the management of chronic obstructive pulmonary disease (COPD).	Muscarinic acetylcholine receptor M3target Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 4transporter Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00685347	Dose Response Study of Levalbuterol in the Prevention of Exercise Induced Bronchoconstriction Compared to Racemic Albuterol in Pediatric Subjects	Albuterol Levosalbutamol	treatment	2	completed
NCT00685425	Dose Response Study of Levalbuterol in the Prevention of Exercise Induced Bronchoconstriction Compared to Racemic Albuterol	Albuterol Levosalbutamol	treatment	3	completed
NCT01903785	Salbutamol, Pharmacogenetics and Breathing Mechanics	Albuterol	basic_science	4	completed