Amebiasis (DBCOND0021893)

Identifiers

Synonyms

Amoebiasis / Amebiasis, unspecified / Amebic infection (disorder) / Amoebiasis, unspecified / Amoebic infections / Amoebiasis NOS / Disease due to Endamoebidae (disorder) / Amebiasis NOS / Infection caused by Entamoeba histolytica (disorder) / Entamoeba histolytica Infection / Amoebic colitis / Amebic dysentery / Amebic colitis / Amebic colitis (disorder) / Dysentery, Amebic / Amoebic dysentery / Intestinal amebiasis / Amebic dysentery (disorder) / Intestinal amoebiasis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetarsol	An anti infective used to treat a wide variety of infections in the body.	No drug targets
Metronidazole	A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.	Oxygen-insensitive NADPH nitroreductasetarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Anaerobic bacterial DNAtarget Protozoal DNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme
Metronidazole benzoate	Not Annotated	No drug targets
Nifuroxazide	An antibiotic indicated in the treatment of susceptible gastrointestinal infections.	No drug targets
Ornidazole	A nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis.	No drug targets
Tinidazole	A nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis.	Cytochrome P450 3A4enzyme DNAtarget Bile salt export pumptransporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02089048	Auranofin PK Following Oral Dose Administration	Auranofin	treatment	1	completed
NCT02385058	Study to Evaluate Efficacy and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population	Mebendazole Quinfamide	treatment	4	completed
NCT02105714	Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders	No drug interventions	Not Available	Not Available	completed
NCT02734264	Field Studies of Amebiasis in Bangladesh	No drug interventions	Not Available	Not Available	completed
NCT00366236	Study of Nitazoxanide in the Treatment of Amebiasis in Adults and Adolescents	Nitazoxanide	treatment	3	completed
NCT00366730	Study of Nitazoxanide in the Treatment of Amebiasis in Children	Nitazoxanide	treatment	3	completed
NCT00001162	Parasitic Infections of the Gastrointestinal Tract	No drug interventions	Not Available	Not Available	terminated