Acetarsol

DB13268ApprovedWithdrawnSmall molecule

Acetarsol is an anti infective used to treat a wide variety of infections in the body. Acetarsol, with the molecular formula N-acetyl-4-hydroxy-m-arsanilic acid, is a pentavalent arsenical compound with antiprotozoal and antihelmintic properties.

Mechanism: The mechanism of action of acetarsol is not well known but it is thought to bind to protein-containing sulfhydryl groups located in the infective microorganism and to form a lethal As-S bond. The formation of this bond impairs the protein to function and it eventually kills the microorganism.
Curator reviewed · 1 reference
Primary indication: Acetarsol has been used for the treatment of different diseases such as syphilis, amoebiasis, yaws, trypanosomiasis, and malaria.Curator reviewed · 2 structured indications
Formula / weight: C₈H₁₀AsNO₅ · 275.0903 g/mol (avg)
First approval: Canada, 1964

Resolves to

Compound

UNII806529YU1NCAS97-44-9ChEMBLCHEMBL1330792ChEBI135135

Clinical / RWD

ATCA07AX02ATCG01AB01ATCP01CD02

Structure

InChIKeyODFJOVXVLFUVNQ-UHFFFAOYSA-NSMILESCC(=O)NC1=CC(=CC=C1O)[As](O)(O)=O

What you can answer from here — as of January 17, 2025

1Drug interactionStructured to mechanism, not free text

2Structured indicationsCondition, population, route and combination as fields, not prose

1Marketed productAcross 1 country and 1 labeller

3ATC codesIncluding every combination product, plus 11 drug categories

11+ReferencesStructured and connected to the statements they support

Which other approved drugs treat the same conditions as Acetarsol, and which companies have late-stage candidates in those indications?

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