moderate Atopic dermatitis (DBCOND0025271)

Identifiers

Synonyms

Moderate Atopic Dermatitis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Abrocitinib	A kinase inhibitor used to treat moderate-to-severe atopic dermatitis in adults.	Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2B6enzyme Tyrosine-protein kinase JAK1target ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 1transporter Tyrosine-protein kinase JAK2target Tyrosine-protein kinase JAK3target Non-receptor tyrosine-protein kinase TYK2target Albumincarrier Organic anion transporter 3transporter
Baricitinib	A Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis that has responded poorly to at least one TNF antagonist.	Organic anion transporter 3transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Multidrug and toxin extrusion protein 2transporter Cytochrome P450 3A4enzyme Tyrosine-protein kinase JAK1target Tyrosine-protein kinase JAK2target Solute carrier family 22 member 6transporter Solute carrier family 22 member 2transporter Solute carrier organic anion transporter family member 1B3transporter Tyrosine-protein kinase JAK3target ATP-dependent translocase ABCB1transporter Non-receptor tyrosine-protein kinase TYK2target
Crisaborole	A non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.	3',5'-cyclic-AMP phosphodiesterase 4Atarget 3',5'-cyclic-AMP phosphodiesterase 4Btarget 3',5'-cyclic-AMP phosphodiesterase 4Ctarget 3',5'-cyclic-AMP phosphodiesterase 4Dtarget Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme
Desonide	A topical corticosteroid used for the symptomatic treatment of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Steroid hormone receptor ERR1target Steroid hormone receptor ERR2target Estrogen-related receptor gammatarget
Dupilumab	A monoclonal antibody used to treat moderate to severe atopic dermatitis, asthma, and nasal polyps accompanied by chronic rhinosinusitis in adolescents and adults.	Interleukin-4 receptor subunit alphatarget Interleukin-13target Interleukin-4target
Fusidic acid	A topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.	Chloramphenicol acetyltransferase 3target Chloramphenicol acetyltransferasetarget Bile salt export pumptransporter ATP-binding cassette sub-family C member 2transporter Elongation factor Gtarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A1enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter
Lebrikizumab	An IgG4 monoclonal antibody against IL-13 used to treat moderate-to-severe atopic dermatitis in adults and adolescents.	Interleukin-13target
Pimecrolimus	A topical calcineurin inhibitor used in the treatment of mild-moderate atopic dermatitis who are not candidates for other types of therapy due to previous lack of response or other reasons.	Peptidyl-prolyl cis-trans isomerase FKBP1Atarget Serine/threonine-protein kinase mTORtarget Cytochrome P450 3A4enzyme Protein phosphatase 3 catalytic subunit alphatarget
Ruxolitinib	A kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment.	Tyrosine-protein kinase JAK1target Tyrosine-protein kinase JAK2target Cytochrome P450 3A4enzyme Cytochrome P450 2C9enzyme Albumincarrier Tyrosine-protein kinase JAK3target Non-receptor tyrosine-protein kinase TYK2target Urokinase plasminogen activator surface receptortarget
Tacrolimus	A calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.	Peptidyl-prolyl cis-trans isomerase FKBP1Atarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Cholesterol transporter ABCA5transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier Solute carrier organic anion transporter family member 1B1transporter Protein phosphatase 3 catalytic subunit alphatarget

Clinical Trials

Not Available