chronic heart failure with reduced ejection fraction (NYHA Class II) (DBCOND0025714)

Identifiers

Synonyms

NYHA Class II Congestive heart failure / NYHA Class II Heart failure / Heart Failure NYHA Class II / Chronic heart failure / Cardiac failure chronic / Chronic heart failure (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Candesartan cilexetil	An angiotensin receptor blocker used to treat hypertension, systolic hypertension, left ventricular hypertrophy, and delay progression of diabetic nephropathy.	Type-1 angiotensin II receptortarget Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme ATP-dependent translocase ABCB1transporter UDP-glucuronosyltransferase 1A3enzyme Prostaglandin G/H synthase 1enzyme
Dapagliflozin	A sodium-glucose cotransporter 2 inhibitor used in the management of type 2 diabetes mellitus.	Sodium/glucose cotransporter 2target Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B4enzyme UDP-glucuronosyltransferase 2B7enzyme ATP-dependent translocase ABCB1transporter
Eplerenone	An aldosterone receptor antagonist used to improve survival of patients with symptomatic heart failure and to reduce blood pressure.	Mineralocorticoid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 11B2, mitochondrialenzyme
Ferric carboxymaltose	An iron replacement therapy used to treat iron deficiency anemia in children and adults with intolerance or inadequate clinical response to oral iron, and in adult patients who have non-dialysis dependent chronic kidney disease.	No drug targets
Furosemide	A loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension.	Solute carrier family 12 member 1target Albumincarrier Solute carrier family 22 member 6transporter Organic cation/carnitine transporter 2transporter Organic anion transporter 3transporter ATP-binding cassette sub-family C member 2transporter Solute carrier organic anion transporter family member 2A1transporter Solute carrier family 22 member 11transporter 6-phosphogluconate dehydrogenase, decarboxylatingenzyme Carbonic anhydrase 2target UDP-glucuronosyltransferase 1A1enzyme Thyroxine-binding globulincarrier G-protein coupled receptor 35target
Iobenguane sulfate I-123	For use in the diagnostic imaging of adrenergically inervated tissues for the purposes of detecting metastatic pheochromocytoma or neuroblastoma [FDA Label]. Also used to assess the sympathetic inervation of the...	Sodium-dependent noradrenaline transportertransporter
Metoprolol	A beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction.	Beta-1 adrenergic receptortarget Cytochrome P450 2D6enzyme Beta-2 adrenergic receptortarget Solute carrier family 22 member 2transporter Albumincarrier Cytochrome P450 3A4enzyme Beta adrenergic receptortarget
Perindopril	An ACE inhibitor prodrug used to treat hypertension, mild to moderate congestive heart failure, and to reduce cardiovascular risk in patients with hypertension or post-myocardial infarction.	Angiotensin-converting enzymetarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Cholinesteraseenzyme Secreted frizzled-related protein 4target
Valsartan	An angiotensin-receptor blocker used to manage hypertension alone or in combination with other antihypertensive agents and to manage heart failure in patients who are intolerant to ACE inhibitors.	Type-1 angiotensin II receptortarget Cytochrome P450 2C9enzyme Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1B1transporter ATP-binding cassette sub-family C member 2transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06641284	Gender-Based Differences in Heart Failure Hospitalizations Among Patients With Heart Failure Treated With Spironolactone	Spironolactone	Not Available	Not Available	recruiting
NCT06646601	A Preventive, Multidisciplinary Primary Care Intervention Organized Around a Therapeutic Garden: Acceptability to Patients Suffering from Cardio-neurovascular Pathology and to Those Involved in the Action.	No drug interventions	prevention	Not Available	recruiting
NCT01669395	Severe Heart Failure and Homebased Rehabilitation - An Intersectoral Randomized Controlled Trial	No drug interventions	treatment	Not Available	unknown_status
NCT04741191	Cycle Ergometer Training and Heart Failure on Heart Rate Recovery and Mind Fullness	No drug interventions	treatment	Not Available	completed
NCT05487365	Implementation and Cost-evaluation of a Smartphone-based Telemonitoring and Digital Support in Patients With HF	No drug interventions	other	Not Available	unknown_status
NCT03424265	Nutritional Therapy Interventions in Heart Failure	No drug interventions	basic_science	Not Available	completed
NCT03035565	Cognitive Intervention to Improve Memory in Heart Failure Patients	No drug interventions	treatment	Not Available	completed
NCT05835063	A Study to Improve Physician-Youth Communication and Medical Decision Making	No drug interventions	treatment	Not Available	completed
NCT04218435	Impact of Sacubitril/Valsartan on Quality of Life and Mortality of CKD vs Non-CKD in Heart Failure Patients	Sacubitril Valsartan	Not Available	Not Available	completed
NCT04180696	Mid-Q Response Study	No drug interventions	treatment	Not Available	completed
NCT03388918	Future Patient - Telerehabilitation of Heart Failure Patients	No drug interventions	treatment	Not Available	completed
NCT04452149	Algorithm Using LINQ Sensors for Evaluation And Treatment of Heart Failure	No drug interventions	treatment	Not Available	recruiting
NCT04573699	Cardiac Neuromodulation for Heart Failure	No drug interventions	Not Available	Not Available	unknown_status
NCT01560871	Effects of a Walking Program and Inspiratory Muscle Training in Individuals With Chronic Heart Failure	No drug interventions	treatment	Not Available	completed
NCT04971993	Step and Walking Pattern From Cardiac Monitor Study	No drug interventions	Not Available	Not Available	terminated
NCT05934487	PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III	No drug interventions	diagnostic	Not Available	recruiting
NCT03005184	Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2	Enalapril Icatibant Sacubitril Valsartan	basic_science	2	withdrawn
NCT06313684	Comprehensive Hybrid Cardiac Rehabilitation Trial on Heart Failure	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT06233695	Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure	Potassium	Not Available	Not Available	completed
NCT06521281	The Effect of Chan-Chuang Qigong on Fatigue, Exercise Capacity and Quality of Lifpatients With Heart Failure	No drug interventions	supportive_care	Not Available	completed
NCT04862273	Native T1 CMR Imaging for Diagnosis of Cardiac Amyloidosis	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT03895073	HEart fAiluRe evaluaTion Questionnaire	No drug interventions	Not Available	Not Available	completed
NCT06306573	CardioMEMS HF System Real-World Evidence Post-Approval Study	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT03180320	Baduanjin-eight-silken-movement With Self-efficacy Building for Patients With Chronic Heart Failure (BESMILE-HF Study)	No drug interventions	treatment	Not Available	unknown_status
NCT06394986	Cardio-fistular Recirculation in Patients With Chronic Heart Failure and Preserved Left Ventricle Ejection Fraction	No drug interventions	Not Available	Not Available	completed
NCT03095196	Multipolar CRT-d and Diabetes	No drug interventions	Not Available	Not Available	completed
NCT04829617	Promoting Well-being and Health in Heart Failure	No drug interventions	treatment	Not Available	recruiting
NCT03387813	Hemodynamic-GUIDEd Management of Heart Failure	No drug interventions	treatment	Not Available	completed
NCT05702970	Beneficial Effects of Vitamin D Combined With Oral Iron Supplementation in Patients With Chronic Heart Failure and Iron Deficiency	Ferric carboxymaltose Iron Iron polymaltose Vitamin D	treatment	4	not_yet_recruiting
NCT05336175	Biomarker Study: Heart Failure Patients at Risk	Angiotensin 1-7	treatment	1 / 2	unknown_status
NCT05632432	Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery	No drug interventions	treatment	Not Available	recruiting
NCT05885607	Early Metabolic Adaptations to SGLT2 Inhibition in Heart Failure	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT03947853	Clinical Study to Evaluate the Predictive Value of the Heart Failure Questionnaire (HF-Q) for the Occurrence of Μajor Αdverse Cardiovascular Events (MACE) in Patients With Symptomatic Heart Failure	No drug interventions	Not Available	Not Available	withdrawn