Iobenguane sulfate I-123

DB09546ApprovedSmall moleculeRadioactive Diagnostic Agent

Iobenguane sulfate I-123 is a radiopharmaceutical used in gamma-scintigraphy of adrenergically inervated tissues [FDA Label].

Mechanism: Iobenguane I-123 is transported into adrenergic nerve terminals via the noradrenaline uptake transporter. It is rapidly cleared from systemic circulation and collected in adrenergically invervated tissues. This allows for gamma-scintigraphic imaging of these tissues and their associated organs for diagnostic purposes.
Curator reviewed
Primary indication: For use in the diagnostic imaging of adrenergically inervated tissues for the purposes of detecting metastatic pheochromocytoma or neuroblastoma.Curator reviewed · 4 structured indications
Formula / weight: C₁₆H₂₂I₂N₆O₄S · 640.26 g/mol (avg)
Also known as: Iobenguane sulfate I 123

Resolves to

Compound

UNII23X1185WBOCAS80663-95-2ChEMBLCHEMBL3989523PubChem56840904

Clinical / RWD

RxNorm1427223

Structure

InChIKeyXNACDNPGABUBFR-FKNPGSCZSA-NSMILESOS(O)(=O)=O.NC(=N)NCC1=CC([123I])=CC=C1.NC(=N)NCC1=CC([123I])=CC=C1

Transporters

P23975SLC6A2

What you can answer from here — as of April 02, 2025

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

733Drug interactionsStructured to mechanism, not free text

4Structured indicationsCondition, population, route and combination as fields, not prose

1Marketed productAcross 1 country and 1 labeller

Which other approved drugs treat the same conditions as Iobenguane sulfate I-123, and which companies have late-stage candidates in those indications?

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