Traveler's Diarrhea (DBCOND0040361)
Identifiers
- Synonyms
- Travelers Diarrhea / Traveler's Diarrhoea / Acute Gastroenteritis in Adult Travelers / Traveler's diarrhea / Traveller's diarrhoea / Traveler's diarrhea (disorder) / Dysentery NOS / Infectious diarrheal disease (disorder) / Infectious diarrhea / Dysentery / Diarrhoea infectious / Diarrhea infectious / Infectious diarrhoea
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Azithromycin A macrolide antibiotic used to treat a variety of bacterial infections.- 23S ribosomal RNAtarget
- ATP-dependent translocase ABCB1transporter
- Cytochrome P450 3A4enzyme
- Protein-arginine deiminase type-4target
- ATP-binding cassette sub-family C member 2transporter
Bismuth subsalicylate An antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.- Albumincarrier
- Serotransferrincarrier
Loperamide A long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis.- Voltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
- Mu-type opioid receptortarget
- Pro-opiomelanocortintarget
- Delta-type opioid receptortarget
- Cytochrome P450 3A4enzyme
- ATP-dependent translocase ABCB1transporter
- Kappa-type opioid receptortarget
- Cytochrome P450 2C8enzyme
- Cytochrome P450 2B6enzyme
- Cytochrome P450 2D6enzyme
- Voltage-gated inwardly rectifying potassium channel KCNH2target
- Calmodulintarget
Norfloxacin A broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine.- DNA gyrase subunit Atarget
- DNA topoisomerase 4 subunit Atarget
- DNA topoisomerase 2-alphatarget
- Cytochrome P450 1A2enzyme
- Cytochrome P450 3A4enzyme
- Organic cation/carnitine transporter 2transporter
- Solute carrier family 22 member 6transporter
- Cytochrome P450 1A1enzyme
- Cytochrome P450 3A7enzyme
- DNA gyrase subunit Atarget
- DNA topoisomerase 2target
- DNA topoisomerase 4 subunit Atarget
- DNA gyrase subunit Btarget
Ofloxacin An antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.- DNA gyrase subunit Atarget
- DNA topoisomerase 4 subunit Atarget
- DNA topoisomerase 2-alphatarget
- Cytochrome P450 1A2enzyme
- Organic cation/carnitine transporter 2transporter
- Multidrug resistance-associated protein 1transporter
- Solute carrier family 22 member 6transporter
- ATP-binding cassette sub-family C member 2transporter
- Solute carrier family 22 member 4transporter
- Bile salt export pumptransporter
- DNA gyrase subunit Atarget
- DNA gyrase subunit Btarget
Rifaximin A rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults.- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT05933525 Clinical Study to Assess the Efficacy of IMM-124E (Travelan®) in a Controlled Human Infection Model No drug interventions prevention 2 active_not_recruiting NCT06556940 G.I. Pharmacokinetics of LMN-401 in Individuals With Ileostomies No drug interventions basic_science 0 not_yet_recruiting NCT06363890 Etiology of Travelers' Diarrhea in Australian Tourists Traveling to Southeast Asia No drug interventions Not Available Not Available recruiting NCT02866201 Etiological Diagnosis of Traveler's Diarrhoea No drug interventions diagnostic Not Available completed NCT00392574 Safety and Efficacy of Prulifloxacin Versus Placebo in Traveler's Diarrhea treatment 3 completed NCT03301103 PTM202 and Modulation of Host Resistance to Diarrheagenic E. Coli No drug interventions treatment Not Available completed NCT04026984 Evaluate Safety and Efficacy of Rifamycin SV MMX in the Treatment of Traveler's Diarrhea in Children Age 6 to 11 Years treatment 2 not_yet_recruiting NCT02920242 A Study Comparing Two Rifaximin Tablets in Patients With Travelers' Diarrhea. treatment 3 terminated NCT01005849 Probiotics and the Prevention of Traveler's Diarrhea No drug interventions prevention 4 terminated NCT00564863 Dose-Finding Study of CS19 Expressing ETEC Challenge Strains No drug interventions other 1 completed NCT02736539 Clinical Trial of CBS-2004 in Prevention of Travelers' Diarrhea No drug interventions prevention 3 withdrawn NCT01040325 Traveler's Diarrhea (TD) Vaccine Asia Efficacy Study No drug interventions prevention 2 completed NCT05677282 Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide Adjunct treatment 4 recruiting NCT03866291 ESBL in Patients Returning to Sweden With Traveller's Diarrhoea No drug interventions Not Available Not Available completed NCT01142089 Study to Evaluate Safety and Efficacy of Rifamycin SV Multi-Matrix System (MMX) for the Treatment of Traveler's Diarrhea (TD) treatment 3 completed NCT03535272 Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea prevention 3 terminated NCT00993681 Travelers' Diarrhea (TD) Vaccine Pivotal Efficacy Study No drug interventions prevention 3 completed NCT00564577 Dose-Finding Study of WS6788A and LSN03-016011/A Enterotoxigenic E. Coli ETEC Challenge Strains That Express CS17 No drug interventions screening 1 completed NCT00875875 Single Daily Dose Rifaximin for the Treatment of Travelers' Diarrhea treatment 4 withdrawn NCT00672035 Prevention, Randomized, Double-Blinded, Placebo-Controlled, Parallel Assignment, Safety/Efficacy Study No drug interventions prevention 2 completed NCT01208922 Rifamycin SV-MMX® Tablets Versus Ciprofloxacin Capsules in Acute Traveller's Diarrhoea treatment 3 completed NCT04027894 Study to Evaluate Safety and Efficacy of Rifamycin SV MMX in Treating Traveler's Diarrhea in Children Age 12 to 17 Years treatment 2 not_yet_recruiting NCT00292344 Rifaximin, Loperamide and the Combination to Treat Travelers' Diarrhea treatment 4 completed NCT02498301 Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD prevention Not Available completed NCT00524004 Safety and Efficacy of Bovine Milk Immunoglobulin Against CS17 and CsbD No drug interventions prevention 2 completed