Uncomplicated Urinary Tract Infections (DBCOND0053856)

Identifiers

Synonyms

Uncomplicated Urinary Tract Infection

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cefepime	A fourth-generation cephalosporin antibiotic used in the treatment of infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections.	Organic cation/carnitine transporter 2transporter Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Penicillin-binding protein 2target Peptidoglycan synthase FtsItarget Cell division proteintarget Penicillin-binding protein 2target Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 1Btarget
Cefixime	A third generation cephalosporin used to treat susceptible Gram-negative and Gram-positive bacterial infections.	Solute carrier family 15 member 1transporter Penicillin-binding proteintarget Penicillin-binding protein 2target Solute carrier family 22 member 7transporter Organic anion transporter 3transporter Solute carrier family 15 member 2transporter
Cefpodoxime	A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis.	Peptidoglycan synthase FtsItarget
Cilastatin	A renal dehydropeptidase inhibitor used to prevent degradation of imipenem. Both medications are used together to treat a variety of infections.	Dipeptidase 1target Solute carrier family 22 member 6transporter Organic anion transporter 3transporter
Ciprofloxacin	A second generation fluoroquinolone used to treat various susceptible bacterial infections.	DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 2-alphatarget Cytochrome P450 1A2enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Potassium voltage-gated channel subfamily H member 2target DNA gyrase subunit Atarget DNA topoisomerase 4 subunit Atarget DNA topoisomerase 4 subunit Btarget DNA gyrase subunit Atarget Multidrug resistance protein MdtKtarget Gyrase Atarget DNA gyrase subunit Atarget Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Albumincarrier Thymidylate synthasetarget DNA gyrase subunit Btarget
Imipenem	A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Penicillin-binding protein 3target Dipeptidase 1enzyme Penicillin-binding protein 4target Beta-lactamase SHV-1enzyme Beta-lactamase TEMenzyme Beta-lactamase CTX-Menzyme Beta-lactamaseenzyme Beta-lactamasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT03425396	Oral Omadacycline vs. Oral Nitrofurantoin for the Treatment of Cystitis	Nitrofurantoin Omadacycline	treatment	2	completed
NCT05545137	Clinical Trial of Pivmecillinam Hydrochloride Tablets in the Treatment of Uncomplicated Urinary Tract Infection	No drug interventions	treatment	3	completed
NCT01913860	Supporting the Improvement and Management of Prescribing for Urinary Tract Infections (SIMPle)	No drug interventions	treatment	Not Available	completed
NCT03716804	Establish the Relationship Between Shift in Prescribing Pattern and Associated Shift in Sensitivity Pattern of Causative Microbes in UTI Patients in a Closed Community	No drug interventions	health_services_research	4	completed
NCT01650051	Safety and Efficacy of Phenazopyridine Hydrochloride Tablets, USP 200 mg as an Analgesic for Short-Term Treatment in Female Subjects Suffering From Moderate-to-Severe Pain and Burning Upon Urination Associated With Uncomplicated Urinary Tract Infections (uUTI)	No drug interventions	treatment	3	completed
NCT03354598	Oral Sulopenem-etzadroxil/Probenecid Versus Ciprofloxacin for Uncomplicated Urinary Tract Infection in Adult Women	Ciprofloxacin Probenecid Sulopenem etzadroxil	treatment	3	completed
NCT05138822	Safety, Tolerability, Pharmacokinetic and Microbiological Investigation of GSK3882347 in Female Participants With Urinary Tract Infections	No drug interventions	treatment	1	recruiting