Kidney Transplant Rejection (DBCOND0066662)

Identifiers

Synonyms
Rejection; Transplant, Kidney / Renal Transplant Rejection / Kidney transplant rejection / Acute allograft nephropathy / Renal transplant rejection (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Alemtuzumab
A monoclonal anti-CD52 antibody used in the treatment of B-cell chronic lymphocytic leukemia and relapsing forms of multiple sclerosis.
Antilymphocyte immunoglobulin (horse)
A primarily IgG immune globulin used to manage allograft rejection in renal transplant patients.
No drug targets
Azathioprine
An immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis.
Belatacept
A selective T-cell costimulation blocker used in the prophylaxis of organ rejection in adult patients receiving a kidney transplant.
Cyclosporine
A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
Everolimus
A mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
Mycophenolic acid
An immunosuppressant used to prevent organ transplant rejections.
Tacrolimus
A calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04046549
A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplantprevention2completed
NCT06474273
TACKLE-IT Trial - Treat Acute T Cell Rejection With Evidence and Confidence in Kidney Transplant Recipientstreatment4not_yet_recruiting
NCT03192007
Multi-Parametric MRI for Renal TransplantationNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00866879
Randomized Conversion of Calcineurin-Inhibitors in Renal Allograft Recipientsprevention4completed
NCT02500251
Belimumab Impacting Transplant Eligibilitytreatment1 / 2completed
NCT00771745
Prospective Pilot Study of Pre-Transplant Thymoglobulin Administration in Living Donor Renal Transplant Recipientsprevention4completed
NCT00983645
A Trial Comparing Prograf and Neoral Use in Kidney Transplant Recipients of Hispanic Ethnicitytreatment4terminated
NCT00695097
The Effect of Rituximab on the Development of Anti-Donor AntibodiestreatmentNot Availablecompleted
NCT04114188
Tacrolimus After rATG and Infliximab Induction Immunosuppression (RIMINI)treatment2completed
NCT06438107
Deep Phenotyping of the Renal Allograft to Prognosticate Clinical OutcomesNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05385432
Induction in Sensitized Kidney Transplant Recipients Without Pre-existing Donor-specific antiboDiestreatment3not_yet_recruiting
NCT03422224
ALLoreactive T-Cell receptOr RePertoire in kidnEy tranSplantationNo drug interventionsNot AvailableNot Availablerecruiting
NCT02057965
Mesenchymal Stromal Cell Therapy in Renal Recipientstreatment2unknown_status
NCT01953120
Mechanisms of Belatacept Effect on Alloimmunity and Antiviral Response After Kidney Transplantation (BMS IM 103-309)prevention4completed
NCT03511560
Envarsus on the Effect of Total Tacrolimus Dose/Trough Level Ratio on Renal Function (eGFR) in Kidney Transplantationprevention4completed
NCT03646344
Heme Arginate in Transplantation Studytreatment3terminated
NCT02409940
To Elucidate the Effect of Mesenchymal Stem Cells on the T Cell Repertoire of the Kidney Transplant Patientsbasic_science1unknown_status
NCT03780101
Pathology and Imaging in Kidney AllograftsNo drug interventionsNot AvailableNot Availableterminated
NCT01239472
Cytokines Evaluation in Early Calcineurin Inhibitors Withdrawn on Renal Transplantprevention4completed
NCT02006108
Imaging Kidney Transplant Rejection Using Ferumoxytol-Enhanced Magnetic ResonancediagnosticNot Availablecompleted
NCT02284464
Steroid Withdrawal and Donor-specific Anti-HLA Antibodies in Renal Transplant Patientstreatment4completed
NCT02377193
Simulect Versus ATG in Sensitized Renal Transplant Patienttreatment4completed
NCT01413685
Calcineurin Activity in Renal RecipientsNo drug interventionsdiagnostic4terminated
NCT02581436
Testing Immunosuppression Threshold in Renal Allografts To Extend eGFRNo drug interventionspreventionNot Availablecompleted
NCT05756036
Torque Teno Virus: A Biomarker of ImmunosuppressionNo drug interventionsNot AvailableNot Availablerecruiting
NCT01324934
Efficacy and Safety of ATG-Fresenius Following a Renal Transplantation, Without Corticosteroidstreatment3terminated
NCT01631058
Renal Transplantation in the Elderly - nEverOld Studytreatment4unknown_status
NCT03719339
VIRTUUS Children's StudyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05073822
NOMINATE/ Minimisation of Immunosuppression in Kidney Transplantationprevention1 / 2withdrawn
NCT04530630
Switch to Bictegravir/Emtricitabine/Tenofovir Alafenamide After Renal Transplanttreatment4active_not_recruiting
NCT02490020
A Perspective Multicenter Controlled Study On Application Of Mesenchymal Stem Cell(MSC) To Prevent Rejection After Renal Transplantation By Donation After Cardiac DeathNo drug interventionsprevention1unknown_status
NCT02866682
Prospective Study Comparing Brand and Generic Immunosuppression on Transplant Outcomes, Adherence, & Immune Response in Kidney Transplant Recipientstreatment4completed
NCT03512431
Dose Adjustment of Tacrolimus Based on Home Sampling in Renal Transplant RecipientsNo drug interventionsNot AvailableNot Availablecompleted
NCT00658073
Induction Therapy With Autologous Mesenchymal Stem Cells for Kidney AllograftsNo drug interventionstreatmentNot Availablecompleted
NCT03705091
MRI in Renal TransplantationNo drug interventionsNot AvailableNot Availableunknown_status
NCT03707262
Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister DonorNo drug interventionstreatment1 / 2recruiting
NCT03991780
Fostamatinib in the Treatment of Chronic Active Antibody Mediated Rejectiontreatment1 / 2unknown_status
NCT02733029
Contrast Enhanced Ultrasonography to Detect Human Renal Transplant Rejectiondiagnostic2completed
NCT03140514
Urine CXCL10 Chemokine Monitoring Post-renal TransplantNo drug interventionsdiagnosticNot Availablecompleted
NCT04239703
Trifecta-Kidney cfDNA-MMDx StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05112315
Clinical Impact of the IBox As an Early Intervention TooLNo drug interventionspreventionNot Availableactive_not_recruiting
NCT06126380
Long-Term Safety and Efficacy of Tegoprubart in Kidney Transplant Recipientstreatment2enrolling_by_invitation
NCT03652402
Precision Risk Stratification in Kidney Transplant Patients - EU-TRAINNo drug interventionsNot AvailableNot Availablecompleted
NCT04091984
The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03605654
Cellular Immunotherapy in Recipients of Human Leukocyte Antigen (HLA)-Mismatched, Living Donor Kidney Transplantsprevention2 / 3withdrawn
NCT04019353
Cf-DNA Assay During Treatment of Acute RejectionNo drug interventionsNot AvailableNot Availablecompleted
NCT05897047
Prospective, Randomized Controlled TrialNo drug interventionspreventionNot Availablerecruiting
NCT03363945
Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplantsprevention3completed
NCT04398498
Molecular Biomarkers in Renal Transplantation Via TruGraf® TestNo drug interventionsNot AvailableNot Availableunknown_status
NCT03897205
An Efficacy and Safety Study of Imlifidase in Treatment of Antibody-Mediated Rejection in Kidney Transplant Patientstreatment2completed
NCT03994783
Transplant Antibody-Mediated Rejection: Guiding Effective Treatmentstreatment3active_not_recruiting
NCT06342128
Molecular Landscape of Microvascular Inflammation in Kidney AllograftsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06365411
GEnomic Medicine in Kidney Transplantation StudyNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03488771
Evaluation of Cell-mediated Immune Response by QuantiFERON Monitor® Assay in Kidney Transplant RecipientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05285878
Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantationtreatment2enrolling_by_invitation
NCT04143178
Expressive Writing in Kidney Transplant PatientsNo drug interventionstreatmentNot Availablecompleted
NCT04225988
Comparison of Tacrolimus Extended-Release (Envarsus XR) to Tacrolimus Immediate-Release in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipientstreatment4completed
NCT05727709
Dynamic Changes of Torquetenovirus (TTV) Load in Chinese Renal Transplant RecipientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04953715
Microbiome and Immunosuppression: The Mission StudyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04491552
TruGraf® Long-term Clinical Outcomes StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05482100
CLinical Utility of the omnigrAf® biomarkeR Panel In The Care of kidneY Transplant RecipientsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06505200
Observational Cohort Study Renal Transplantation University Hospitals LeuvenNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03965559
The Efficacy of Plasmapheresis and Double Filtration Plasmapheresis (DFPP) in Kidney TransplantNo drug interventionsNot AvailableNot Availablecompleted
NCT05983770
Safety and Efficacy of Tegoprubart in Patients Undergoing Kidney Transplantationtreatment2recruiting
NCT03789006
Antithymocyte Globulin and Azathioprine Versus Basiliximab and Mycophenolate Mofetil in Living Donor Kidney Transplantationprevention4unknown_status
NCT04266613
TruGraf® Testing in High-Risk Kidney Transplant RecipientsNo drug interventionsNot AvailableNot Availableterminated
NCT05600634
Multi Center Observation of Sentinel Skin Graft for Detecting Acute Rejection After Renal TransplantationNo drug interventionsNot AvailableNot Availablerecruiting
NCT05779124
BAFF/APRIL in Kidney Transplant Rejection Risk AssessmentNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04267016
Acceptability and Feasibility of TruGraf® Testing as Part of the Standard of CareNo drug interventionsNot AvailableNot Availableterminated
NCT06013358
ddcfDNA in Kidney Transplant RecipientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02974686
Conversion From MPA to Zortress (Everolimus) for GI Toxicity Post-renal Transplantationtreatment4terminated
NCT06314230
Australian Genomics Of Chronic Allograft Dysfunction StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05747274
SRDK0921_ Analytical Performance StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03326076
Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure RegistryNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04204980
Desensitization in Kidney Allograft Using Daratumumabtreatment1 / 2completed
NCT06243289
Improving KIdney Transplantation With Cellular Therapy StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04773392
Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXRtreatment4recruiting
NCT04154267
Protocol Biopsies in High-risk Renal Transplant RecipientsNo drug interventionspreventionNot Availableactive_not_recruiting
NCT05811468
Study Correlation Between Blood, Tissue Gene Expression, Donor Derived Cell Free DNA and Histopathology in Kidney Transplant RecipientsNo drug interventionsNot AvailableNot Availablewithdrawn
NCT05872568
Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in de Novo Kidney Transplant Recipientsprevention4not_yet_recruiting
NCT06496269
Impact of Microvascular Inflammation on Kidney Allograft OutcomeNo drug interventionsNot AvailableNot Availablecompleted
NCT06348446
Tacrolimus Exposure in Kidney TransplantationNo drug interventionsNot AvailableNot Availablerecruiting
NCT03606746
Cellular Immunotherapy for Immune Tolerance in Past Recipients of HLA Zero-mismatch, Living Donor Kidney TransplantsNo drug interventionstreatment2withdrawn
NCT04367610
Effects of A Standardized Treatment Approach on Kidney Transplant Recipients With Antibody-Mediated RejectionNo drug interventionsNot AvailableNot Availablecompleted
NCT04177095
Immune Monitoring to Facilitate Belatacept Monotherapydiagnostic4completed
NCT05306795
Development and Validation of a Comprehensive Classification Automation System for Kidney Allograft BiopsiesNo drug interventionsNot AvailableNot Availableunknown_status
NCT04601155
Transition of Renal Patients Using AlloSure Into Community Kidney CareNo drug interventionsNot AvailableNot Availablecompleted
NCT04566055
Assessing AlloSure Dd-cfDNA Monitoring Insights of Renal Allografts With Longitudinal SurveillanceNo drug interventionsNot AvailableNot Availableunknown_status
NCT04078750
PLATO - Medication Adherence in Transplant RecipientsNo drug interventionspreventionNot Availableactive_not_recruiting
NCT03873623
The TOGETHER Project - KidneyNo drug interventionsNot AvailableNot Availablecompleted
NCT05335538
TruGraf and TRAC In Pediatrics StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT05061303
Omeprazole and Famotidine in Chronic Dysfunction of the Transplanted KidneyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06087003
Pediatric Induction Therapy in Kidney TransplantationNot AvailableNot Availablecompleted
NCT06291103
Screening for Subclinical Antibody Mediated Rejection and Efficacy of Belatacept in the Context of de Novo Donor Specific Antibody After Kidney Transplantation (BELA-M-R)treatment2 / 3not_yet_recruiting
NCT05995379
Donor Derived Cell-free DNA and Rejection of Kidney AllograftsNo drug interventionsNot AvailableNot Availablecompleted
NCT04849533
Belatacept With Early Steroid Withdrawal rATG and Everolimus in Renal Transplantation (BETTER Trial)treatment4unknown_status
NCT02012153
Mesenchymal Stromal Cells in Kidney Transplant Recipientstreatment1terminated
NCT05747053
Personalization of Immunosuppressive Treatment for Organ Transplant RecipientsNo drug interventionsNot AvailableNot Availableterminated
NCT03380377
Clazakizumab for Chronic and Active Antibody Mediated Rejection Post-Kidney Transplanttreatment1 / 2completed
NCT06445205
Utilising Volumetric Absorptive Microsampling (VAMS) Technology to Monitor Tacrolimus and CreatinineNo drug interventionsNot AvailableNot Availablerecruiting
NCT03859388
Longitudinal Changes in Donor-Derived Cell-Free DNA With Tocilizumab Treatment for Chronic Antibody-Mediated RejectionNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04727788
Validation of Genomic Immune-phenotyping Profiles to Predict Risk of Kidney Transplant RejectionNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04130685
Donor-Derived Cell-Free DNA for Surveillance in Simultaneous Pancreas and Kidney Transplant RecipientsNo drug interventionsNot AvailableNot Availablecompleted
NCT03874299
The TOGETHER Project - Kidney RNA-seq ValidationNo drug interventionsNot AvailableNot Availablecompleted
NCT06564649
Urinary CXCL10 Pilot Implementation TrialNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03380936
Pilot Study of Treatment for Subclinical AMR (Antibody-mediated Rejection) in Kidney Transplant Recipientstreatment0terminated
NCT05836636
Immune Monitoring of Prevalent Kidney Transplant Recipients Using Torque Teno Virus: A Single-Center, Prospective Cohort StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05785936
Immune Response in Desensitized PatientsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03714113
Donor-specific Anti-HLA Antibodies Monitoring in Kidney Transplant RecipientsNo drug interventionspreventionNot Availableunknown_status
NCT03006419
Basiliximab vs Low-dose Thymoglobulin Induction Therapy in Low Risk Kidney Transplant Patientstreatment4completed
NCT04414735
Impact of Photopheresis in the Prevention of Acute Rejection in Highly Sensitized de Novo Kidney Transplant RecipientsNo drug interventionspreventionNot Availablerecruiting
NCT03663335
Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Kidney Transplant Recipientstreatment2completed
NCT04827186
Spleen Transplant in Solid Organ TransplantationNo drug interventionstreatmentNot Availablewithdrawn
NCT04702022
Added Value of 18 FDG Pet-scanner in Diagnosis and Management of Subclinical Rejection in Kidney Transplant PatientsNo drug interventionsdiagnosticNot Availablerecruiting
NCT04670926
Immunosuppression Management in Renal Transplant Recipients With Transplant Excellence Based on TruGraf TestNo drug interventionsdiagnosticNot Availableunknown_status
NCT06100965
Reduced-dose Alemtuzumab for Kidney Transplant RejectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT05432765
AIIM Trial: Personalized Medicine Approach to Kidney Allograft FunctionNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04817774
Safety & Tolerability Study of Chimeric Antigen Receptor T-Reg Cell Therapy in Living Donor Renal Transplant RecipientsNo drug interventionsprevention1 / 2active_not_recruiting
NCT04560582
Immunosuppression Reduction in Failed Allograft Guided by cfDNANo drug interventionsNot AvailableNot Availablewithdrawn
NCT05987527
Long-Term Follow-Up of TX200-TR101 (STEADFAST Long Term)No drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT04657562
The New LC-MS/MS Method for Determination of Unbound Tacrolimus in PlasmaNot AvailableNot Availableunknown_status
NCT04825262
Efficacy of Achieving Early Target Trough Levels of Tacrolimus Using CYP3A5 Guided Dosing Versus Weight-based Dosing in a Multi-ethnic Population of Kidney Transplant Recipients in SingaporetreatmentNot Availableactive_not_recruiting
NCT06025240
Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant RecipientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04156204
Immunosuppressant Medication Dosed Daily After Kidney Transplantother0terminated
NCT04736381
Impact of the Microbiota on the Likelihood of Renal Graft RejectionNot AvailableNot Availablenot_yet_recruiting
NCT04711850
An Long-term Follow-up Trial of Kidney Tx Patients Treated With Imlifidase or PE After an AMRNot AvailableNot Availableterminated
NCT03304223
IL2 Imaging in Renal TransplantationNo drug interventionsdiagnosticNot Availableactive_not_recruiting
NCT04897438
Donor-derived Cell-free DNA for Early Diagnosis of Antibody-mediated RejectionNo drug interventionsdiagnosticNot Availableactive_not_recruiting