Thrombotic Microangiopathies (DBCOND0072350)

Identifiers

Synonyms

Thrombotic Microangiopathy / Thrombotic microangiopathy (disorder) / Thrombotic microangiopathy NOS / Other thrombotic microangiopathy / Purpura, Thrombotic Thrombocytopenic / Moschcowitz syndrome / Thrombocytopenic purpura, thrombotic / Purpura thrombopenic thrombotic / Purpura thrombopaenic thrombotic / Thrombotic thrombocytopenic purpura / Thrombotic thrombocytopenic purpura (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Eculizumab	A recombinant humanized monoclonal antibody used to reduce the risk of hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).	Complement C5target
Ravulizumab	A monoclonal antibody used to treat paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and myasthenia gravis.	Complement C5target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04557735	Study of Ravulizumab in Pediatric Participants With HSCT-TMA	Ravulizumab	treatment	3	active_not_recruiting
NCT04777435	Therapeutic Orientation Test in Thrombotic Microangiopathy	No drug interventions	diagnostic	Not Available	recruiting
NCT04543591	Ravulizumab in Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplant	Ravulizumab	treatment	3	recruiting
NCT04743804	Ravulizumab in Thrombotic Microangiopathy Associated With a Trigger	Ravulizumab	treatment	3	terminated
NCT05991245	French National Cohort MATRIX "Renal and Systemic Thrombotic Microangiopathy"	No drug interventions	Not Available	Not Available	recruiting
NCT04845022	Incidence of Snakebite Associated Thrombotic Microangiopathy & Role of Peripheral Blood Smear as a Predictor of Clinical Outcome	No drug interventions	Not Available	Not Available	unknown_status
NCT02604420	Identification and Treatment of Thrombotic Microangiopathies in Allogeneic Stem Cell Transplants	Eculizumab	Not Available	Not Available	completed
NCT02355782	OMS721 Compassionate Use in Patients With Thrombotic Microangiopathy	Narsoplimab	Not Available	Not Available	available
NCT00593229	International Registry and Biorepository for TMA(Thrombotic Microangiopathy)	No drug interventions	Not Available	Not Available	terminated
NCT00726544	Clinical Outcome Study of ARC1779 Injection in Patients With Thrombotic Microangiopathy	Egaptivon pegol	treatment	2	terminated
NCT05996679	Automated Surveillance, Alert, and Rapid Diagnosis of Thrombotic Microangiopathies: the ASARD-TMA Study	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT02222545	Safety and Efficacy Study of OMS721 in Patients With Thrombotic Microangiopathies	Narsoplimab	treatment	2	completed
NCT04570397	Ravulizumab and COVID-19	Ravulizumab	treatment	3	active_not_recruiting
NCT05634928	Construction of a Database for TMA	No drug interventions	Not Available	Not Available	recruiting
NCT02134171	Early Predictive Factors of Cardiac and Cerebral Involvement in TMA	No drug interventions	diagnostic	Not Available	completed
NCT06291415	The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Adult Subjects With Immune Thrombocytopenia (ITP)	Sovleplenib	treatment	1	recruiting
NCT06291025	Efficacy and Safety of Immunosuppression, Caplacizumab and Plasma Infusion Without Therapeutic Plasma Exchange in Immune-mediated Thrombotic Thrombocytopenic Purpura: Multicentric Non-inferiority Single-arm Study	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT03252925	A Safety and Efficacy Study of NAC in Patients With TA-TMA	Acetylcysteine	prevention	3	completed
NCT06102694	Identification of Plasma Biomarkers for Early Diagnosis of Transplant-associated Thrombotic Microangiopathy	No drug interventions	Not Available	Not Available	recruiting
NCT03205995	Safety and Efficacy Study of OMS721 in Patients With Atypical Hemolytic Uremic Syndrome	Narsoplimab	treatment	3	recruiting
NCT04745195	Complement Prospective Evaluation of Thrombotic Microangiopathy on Endothelium	No drug interventions	Not Available	Not Available	unknown_status
NCT03518203	Eculizumab to Treat Thrombotic Microangiopathy/Atypical Hemolytic Uremic Syndrome -Associated Multiple Organ Dysfunction Syndrome in Hematopoietic Stem Cell Transplant Recipients	Eculizumab	treatment	2	completed
NCT04098445	TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients	No drug interventions	Not Available	Not Available	recruiting
NCT05855083	Efficacy and Safety Study of Narsoplimab in Pediatric Patients With High-Risk Hematopoietic Stem Cell Transplant TMA	Narsoplimab	treatment	2	recruiting
NCT03605511	TTP and aHUS in Complicated Pregnancies	No drug interventions	Not Available	Not Available	unknown_status
NCT03384693	Defibrotide TMA Prophylaxis Pilot Trial	Defibrotide	prevention	2	completed
NCT06098378	Study of Patients With Thrombotic Microangiopathy Associated With Mitomycin C, Treated or Not With Eculizumab	No drug interventions	Not Available	Not Available	recruiting
NCT05702996	Multicenter, Uncontrolled Pilot Study Evaluating the Efficacy of Eculizumab in the Treatment of Gemcitabine-induced Thrombotic Microangiopathies	Eculizumab Gemcitabine	treatment	3	not_yet_recruiting
NCT02373267	Screening of TMA Patients für ADAMTS13 Activity (Adamscreen)	No drug interventions	Not Available	Not Available	unknown_status
NCT04970004	Study in Adult and Pediatric Patients With HSCT-TMA	No drug interventions	Not Available	Not Available	withdrawn
NCT06182410	Defibrotide Prophylaxis of Transplant Associated-Thrombotic Microangiopathy for Neuroblastoma	Defibrotide	supportive_care	2	withdrawn
NCT04784455	Nomacopan (rVA576) in Transplant Associated Thrombotic Microangiopathy	Nomacopan	treatment	3	terminated