Deficiency, Vitamin A (DBCOND0085163)

Identifiers

Synonyms

Vitamin A Deficiency / Vitamin A deficiency, unspecified / Unspecified vitamin A deficiency / Vitamin A deficiency (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ascorbic acid	A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron.	Prolyl 4-hydroxylase subunit alpha-1target Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1target Hyaluronate lyasetarget DNAtarget Xylose isomerasetarget Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2target Phytanoyl-CoA dioxygenase, peroxisomaltarget Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3target Gamma-butyrobetaine dioxygenasetarget Dopamine beta-hydroxylasetarget Peptidyl-glycine alpha-amidating monooxygenasetarget Prolyl 3-hydroxylase 1target 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2target DNA oxidative demethylase ALKBH2target Prolyl 3-hydroxylase 2target Prolyl 3-hydroxylase 3target Prolyl 3-hydroxylase OGFOD1target Prolyl hydroxylase EGLN2target Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3target Lysine-specific demethylase 5Dtarget Egl nine homolog 1target Prolyl hydroxylase EGLN3target Trimethyllysine dioxygenase, mitochondrialtarget Transmembrane prolyl 4-hydroxylasetarget Solute carrier family 23 member 1transporter Solute carrier family 23 member 2transporter Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Albumincarrier Thioredoxin reductase 1, cytoplasmicenzyme Solute carrier family 23 member 2target Solute carrier family 23 member 1target
Beta carotene	A vitamin A precursor found in various nutritional supplements and health products.	Beta,beta-carotene 15,15'-dioxygenaseenzyme Free radicalstarget Very low-density lipoprotein receptorcarrier Retinol-binding protein 1carrier Retinol-binding protein 2carrier Retinol-binding protein 3carrier Retinol-binding protein 4carrier Retinol-binding protein 5carrier
Cholecalciferol	A form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.	Vitamin D-binding proteincarrier Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Vitamin D 25-hydroxylaseenzyme Sterol 26-hydroxylase, mitochondrialenzyme Cytochrome P450 2J2enzyme Cytochrome P450 3A4enzyme Vitamin D3 receptortarget Cytochrome P450 1A1enzyme Cytochrome P450 2C8enzyme
Cod liver oil	An ingredient found in a variety of nutritional products.	No drug targets
Ergocalciferol	A vitamin found in many supplement products.	Vitamin D3 receptortarget 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme Sterol 26-hydroxylase, mitochondrialenzyme Vitamin D 25-hydroxylaseenzyme Vitamin D-binding proteincarrier Voltage-dependent calcium channeltarget Ribulose-phosphate 3-epimeraseenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme
Vitamin A	A vitamin important for retinal function that is used clinically to correct vitamin A deficiency.	Retinol dehydrogenase 12target Retinol dehydrogenase 5target Retinol dehydrogenase 13target Retinol-binding protein 5carrier Retinoid-binding protein 7carrier Retinol-binding protein 4carrier Retinol-binding protein 2carrier Retinal dehydrogenase 2target Aldehyde dehydrogenase 1A1target Lecithin retinol acyltransferasetarget Short-chain dehydrogenase/reductase 3target Retinaldehyde dehydrogenase 3target All-trans-retinol 13,14-reductasetarget Retinol dehydrogenase 11target Dehydrogenase/reductase SDR family member 4target Retinol dehydrogenase 14target Retinol dehydrogenase 8target Cytochrome P450 26A1enzyme Apolipoprotein Dtarget Prostaglandin-H2 D-isomerasetarget Albumincarrier Retinaldehyde-binding protein 1carrier Retinol-binding protein 3carrier Retinol-binding protein 1carrier Receptor for retinol uptake STRA6transporter Retinoic acid receptor RXR-gammatarget
alpha-Tocopherol acetate	A form of vitamin E used to treat and prevent vitamin deficiencies.	Cytochrome P450 4F2enzyme Cytochrome P450 3A4enzyme Free radicalstarget Alpha-tocopherol transfer proteintransporter SEC14-like protein 4transporter SEC14-like protein 2transporter SEC14-like protein 3transporter Apolipoprotein B receptortransporter Scavenger receptor class B member 1transporter ATP-dependent translocase ABCB1transporter Very low-density lipoprotein receptorcarrier Low-density lipoprotein receptorcarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02847962	Newly Formulated, Extruded Fortified-blended Foods for Food Aid: the MFFAPP Tanzania Efficacy Study	No drug interventions	treatment	Not Available	completed
NCT02804490	Efficacy of Biofortified Maize to Improve Maternal and Infant Vitamin A Status	No drug interventions	prevention	3	completed
NCT01199445	Efficacy of Vitamin A in Fortified Extruded Rice in School Children	No drug interventions	basic_science	0	completed
NCT01614483	Efficacy of Yellow Cassava to Improve Vitamin A Status of Kenyan School Children	No drug interventions	prevention	Not Available	completed
NCT04632771	Nutritional Status and Bouillon Use in Northern Ghana	No drug interventions	Not Available	Not Available	completed
NCT02210507	Beta-carotene Absorption and Bioconversion to Vitamin A From Biofortified Cassava Gari	No drug interventions	basic_science	Not Available	completed
NCT02363985	Using Stable Isotope Techniques to Monitor and Assess the Vitamin A Status of Children Susceptible to Infection	No drug interventions	basic_science	Not Available	completed
NCT04438200	Liver and Bone Retinol Levels in Guatemalan Adolescents and Adults	No drug interventions	Not Available	Not Available	unknown_status
NCT02996513	Assessing Model Parameters for Applying the Retinol Isotope Dilution (RID) Method	No drug interventions	diagnostic	Not Available	completed
NCT01476358	Effect of Vitamin A Supplementation on Immune Responses in Human Neonates	No drug interventions	Not Available	2	unknown_status
NCT04780958	Retinol Status in Preterm Infants and Mothers	No drug interventions	other	Not Available	completed
NCT00128557	Community Trial of Newborn Vitamin A Supplementation to Reduce Infant Mortality in Rural Bangladesh	No drug interventions	prevention	3	completed
NCT01559766	Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment	No drug interventions	Not Available	Not Available	completed
NCT00082420	Retinol Equivalence of Plant Carotenoids in Children	No drug interventions	Not Available	Not Available	completed
NCT05882682	Impact of Food-to-Food Fortified Cereal Products on Diet Quality in Eldoret, Kenya	No drug interventions	Not Available	Not Available	completed
NCT05323292	Vitamin A Status in Patients With Vocal Fold Leukoplakia	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT03383744	Using Stable Isotopes to Assess the Effectiveness of Vitamin A Supplementation in Cameroon	No drug interventions	treatment	Not Available	completed
NCT05893901	Impact of Food-to-Food Fortified Cereal Products on Diet Quality in Rural Niger Villages	No drug interventions	Not Available	Not Available	completed
NCT03971604	The Correlation Between Vitamin A / E Levels and Preeclampsia	Vitamin A Vitamin E	prevention	Not Available	unknown_status
NCT02027610	Vitamin A, Stool Microbiota and Vaccine Response in Bangladeshi Infants	No drug interventions	Not Available	Not Available	completed
NCT02760095	Effects of EED on Zn Absorption and Retention in Children From a Standard Dose	Vitamin A Zinc sulfate	Not Available	Not Available	completed
NCT02276014	Effect of SNPs in the BCMO1 Enzyme	No drug interventions	basic_science	Not Available	completed
NCT02043223	Stopping Postpartum Vitamin A Supplementation: Missing Concealed Benefit	No drug interventions	prevention	2 / 3	completed
NCT04137354	Iron and Vitamin A in School Children	No drug interventions	prevention	Not Available	completed
NCT05872061	Senegal Market Study for Food-to-Food Fortified (F2F) Instant Porridge Flours	No drug interventions	Not Available	Not Available	completed
NCT02648893	Effect Of Multiple Biofortified Food Crops On Micronutrient Status And Immune Function Among Indian Infants and Their Mothers	No drug interventions	other	Not Available	active_not_recruiting
NCT05178407	Effect of Household Use of Multiple Micronutrient-fortified Bouillon on Micronutrient Status Among Women and Children in Two Districts in the Northern Region of Ghana	No drug interventions	other	Not Available	completed
NCT01061307	An Efficacy Trial of Iron, Zinc and Vitamin A Fortified Rice in Children in Satun, Thailand	No drug interventions	treatment	0	completed
NCT00742937	Impact of Maternal Supplementation With Dual Megadose of Vitamin A	No drug interventions	prevention	2 / 3	completed
NCT03305042	Vitamin A Liver Reserves and Serum Markers of Vitamin A in US Adults at Time of Death	No drug interventions	Not Available	Not Available	completed
NCT01420406	Vitamin A Bioavailability in Lactating Women With Marginal Vitamin A Status	No drug interventions	basic_science	Not Available	completed
NCT01922713	Effect of Daily Consumption of Orange Maize on Breast Milk Retinol in Lactating Zambian Women	No drug interventions	Not Available	Not Available	completed
NCT00198718	Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates	Vitamin A	treatment	2	completed
NCT00211341	Trial of the Impact of Vitamin A on Maternal Mortality	No drug interventions	prevention	3	completed
NCT04694235	Egg Intervention During Pregnancy in Indonesia	No drug interventions	prevention	Not Available	active_not_recruiting
NCT02627222	The Efficacy of Pro-vitamin A Biofortified Cassava on Vitamin A Status in Nigerian Preschool Children	No drug interventions	prevention	Not Available	completed
NCT00198822	Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh	No drug interventions	prevention	3	completed
NCT02702622	Vitamin A Equivalence of the Provitamin A in Biofortified Bananas	No drug interventions	Not Available	Not Available	completed
NCT06450925	Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.	Vitamin A	prevention	2	not_yet_recruiting
NCT00453648	Impact of Consumption of Orange-fleshed Sweet Potatoes on the Vitamin A Status of Bangladeshi Women of Reproductive Age	No drug interventions	treatment	Not Available	completed
NCT01695148	Efficacy of β-carotene Biofortified Maize in Reducing Vitamin A Deficiency Among Children	No drug interventions	prevention	3	completed
NCT01381276	Vitamin A Absorption From Cassava in Women	No drug interventions	basic_science	2	completed
NCT03353662	Sub Regional Micronutrient Survey in Ethiopia	No drug interventions	Not Available	Not Available	unknown_status
NCT00674089	Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan	No drug interventions	prevention	Not Available	completed
NCT03876704	Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants	No drug interventions	treatment	3	unknown_status
NCT03640104	Individualized Dietary Intervention in Breastfeeding Women: Body Weight and Vitamin A Stores	No drug interventions	treatment	Not Available	completed
NCT01583972	Efficacy of Newborn Vitamin A Supplementation in Improving Immune Function	No drug interventions	prevention	Not Available	completed
NCT04153968	Bioefficacy of Beta-cryptoxanthin From Biofortified Maize	No drug interventions	basic_science	Not Available	unknown_status
NCT04127968	Efficacy and Safety of Vitamin A Treatment for Children With Sepsis	Vitamin A	treatment	Not Available	unknown_status
NCT00680212	Vitamin A Equivalence of Plant Carotenoids in Children	No drug interventions	basic_science	2	completed
NCT00053612	Vitamin A to Reduce HIV in Vaginal Secretions and Prevent Viral Transmission	Vitamin A	prevention	2	completed
NCT04123210	Estimating Average Vitamin A Requirements in Indonesian and American Women	No drug interventions	basic_science	Not Available	completed