Streptozocin is a nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma. An antibiotic that is produced by Stretomyces achromogenes.
- Mechanism
- Curator reviewed
Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.
- Primary indication
- For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).Curator reviewed · 1 structured indication
- Formula / weight
- C8H15N3O7 · 265.222 g/mol (avg)
- First approval
- Canada, 2013 · United States, 2003
- Also known as
- 1-METHYL-1-NITROSO-3-((2R,3R,4S,5R)-3,4,5,6-TETRAHYDROXY-1-OXOHEXAN-2-YL)UREA · 1-METHYL-1-NITROSO-3-((3R,4R,5S,6R)-2,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3-YL)UREA · D-GLUCOPYRANOSE, 2-DEOXY-2-(((METHYLNITROSOAMINO)CARBONYL)AMINO)- · Streptozotocin
- Code names
- NSC-85998
- Brand names
Resolves to
AGRCPNMCOXLKFO-BDVNFPICSA-NSMILESCN(N=O)C(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)COWhat you can answer from here — as of September 20, 2026
Which drugs share a target with Streptozocin, and which of those have an active Phase 3 trial?
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