Torasemide is a diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent.
- Mechanism
- Curator reviewed · 4 references
As mentioned above, torasemide is part of the loop diuretics and thus, it acts by reducing the oxygen demand in the medullary thick ascending loop of Henle by inhibiting the Na+/K+/Cl- pump on the luminal cell membrane surface. This action is obtained by the binding of torasemide to a chloride ion-binding site of the transport molecule.
Torasemide is known to have an effect in the renin-angiotensin-aldosterone system by inhibiting the downstream cascade after the activation of angiotensin II. This inhibition will produce a secondary effect marked by the reduction of the expression of aldosterone synthase, TGF-B1 and thromboxane A2 and a reduction on the aldosterone receptor binding.
- Primary indication
- Torasemide is indicated for the treatment of edema associated with congestive heart failure, renal or hepatic diseases.Curator reviewed · 5 structured indications
- Formula / weight
- C16H20N4O3S · 348.42 g/mol (avg)
- First approval
- Canada, 1998 · United States, 2000
- Also known as
- Torsemide
- Code names
- AC-4464 · BM-02.015
- Brand names
Resolves to
NGBFQHCMQULJNZ-UHFFFAOYSA-NSMILESCC(C)NC(=O)NS(=O)(=O)C1=C(NC2=CC=CC(C)=C2)C=CN=C1What you can answer from here — as of September 20, 2026
Which drugs share a target with Torasemide, and which of those have an active Phase 3 trial?
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