Solute carrier family 12 member 1

BE0000502ProteinHumansSLC12A1

Renal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation (PubMed:21321328). It is acted on by 19 drugs in DrugBank.

Gene name
SLC12A1
UniProtKB entry
Q13621Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,099 residues · 121,449 Da
Also known as
BSC1 · Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 · Kidney-specific Na-K-Cl symporter · Na-K-2Cl cotransporter 2 · NKCC2

Resolves to

Protein
UniProtQ13621UniProt nameS12A1_HUMAN
Gene
HGNCHGNC:10910NCBI Gene6557GenBank1373425GeneCardsSLC12A1
Pharmacology
IUPHAR/GtoPdb968KEGGhsa:6557
Drugs

What you can answer from here — as of September 07, 2019

19DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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51+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 12 member 1, how selective are they, and which programs against it are still in active trials?

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