Solute carrier organic anion transporter family member 1B1

BE0001004ProteinHumansSLCO1B1

Mediates the Na(+)-independent uptake of organic anions (PubMed:10358072, PubMed:15159445, PubMed:17412826). It is acted on by 240 drugs in DrugBank.

Gene name
SLCO1B1
UniProtKB entry
Q9Y6L6Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
691 residues · 76,448 Da
Also known as
Liver-specific organic anion transporter 1 · LST-1 · LST1 · OATP-2 · OATP-C

Resolves to

Protein
UniProtQ9Y6L6UniProt nameSO1B1_HUMAN
Gene
HGNCHGNC:10959NCBI Gene10599GenBank5051630GeneCardsSLCO1B1
Pharmacology
IUPHAR/GtoPdb1220KEGGhsa:10599
Structure
PDB8HNBPDB8HNCPDB8HND
Drugs

What you can answer from here — as of September 07, 2019

240DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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378+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier organic anion transporter family member 1B1, how selective are they, and which programs against it are still in active trials?

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