Diphenidol is an antiemetic agent used for the prevention and symptomatic treatment of nausea and vomiting associated with various conditions as Meniere's disease and surgery of the middle and inner ear. Diphenidol overdose may result in serious toxicity in children.
- Mechanism
- Curator reviewed
The mechanism by which diphenidol exerts its antiemetic and antivertigo effects is not precisely known. It is thought to diminish vestibular stimulation and depress labyrinthine function and as an antimuscarinic agent. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Diphenidol has no significant sedative, tranquilizing, or antihistaminic action. It has a weak peripheral anticholinergic effect.
- Primary indication
- For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear.Curator reviewed · 8 structured indications
- Formula / weight
- C21H27NO · 309.4452 g/mol (avg)
- First approval
- United States, 2006
- Also known as
- Difenidol · Difenidolo
- Code names
- SK&F-478
Resolves to
OGAKLTJNUQRZJU-UHFFFAOYSA-NSMILESOC(CCCN1CCCCC1)(C1=CC=CC=C1)C1=CC=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Diphenidol, and which of those have an active Phase 3 trial?
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