Muscarinic acetylcholine receptor M4

BE0000405ProteinHumansCHRM4

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. It is acted on by 54 drugs in DrugBank.

Gene name
CHRM4
UniProtKB entry
P08173Swiss-Prot
Cellular location
Cell membrane
Residues / weight
479 residues · 53,049 Da

Resolves to

Protein
UniProtP08173UniProt nameACM4_HUMAN
Gene
HGNCHGNC:1953NCBI Gene1132GenBank61970253GeneCardsCHRM4
Pharmacology
IUPHAR/GtoPdb16KEGGhsa:1132
Structure
PDB5DSGPDB6D9HPDB6KP6
Drugs

What you can answer from here — as of September 07, 2019

54DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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123+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Muscarinic acetylcholine receptor M4, how selective are they, and which programs against it are still in active trials?

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