Muscarinic acetylcholine receptor M1

BE0000092ProteinHumansCHRM1

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. It is acted on by 116 drugs in DrugBank.

Gene name
CHRM1
UniProtKB entry
P11229Swiss-Prot
Cellular location
Cell membrane
Residues / weight
460 residues · 51,420 Da

Resolves to

Protein
UniProtP11229UniProt nameACM1_HUMAN
Gene
HGNCHGNC:1950NCBI Gene1128GenBank34451GeneCardsCHRM1
Pharmacology
IUPHAR/GtoPdb13KEGGhsa:1128
Structure
PDB5CXVPDB6OIJPDB6WJC
Drugs

What you can answer from here — as of September 07, 2019

116DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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359+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Muscarinic acetylcholine receptor M1, how selective are they, and which programs against it are still in active trials?

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