Podofilox is a topical agent used for the treatment of external genital warts and perianal warts. A lignan found in podophyllin resin from the roots of podophyllum plants.
- Mechanism
- Curator reviewed
The exact mechanism of action is not well understood. It does appear, however, that it and its derivatives may bind and inhibit topoisomerase II during the late S and early G2 stage. The drug may bind and stabilize the temporary break caused by the enzyme. This disrupts the reparation of the break through which the double-stranded DNA passes, and consequently stops DNA unwinding and replication
- Primary indication
- For treatment of external genital warts (Condyloma acuminatum).Curator reviewed · 3 structured indications
- Formula / weight
- C22H22O8 · 414.4053 g/mol (avg)
- First approval
- Canada, 2000 · United States, 1990
- Also known as
- Podophyllotoxin
- Brand names
Resolves to
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Which drugs share a target with Podofilox, and which of those have an active Phase 3 trial?
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