DNA topoisomerase 2-beta

BE0002425ProteinHumansTOP2B

Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken... It is acted on by 56 drugs in DrugBank.

Gene name
TOP2B
UniProtKB entry
Q02880Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
1,626 residues · 183,266 Da
Also known as
5.6.2.2 · DNA topoisomerase II, beta isozyme

Resolves to

Protein
UniProtQ02880UniProt nameTOP2B_HUMAN
Gene
HGNCHGNC:11990NCBI Gene7155GeneCardsTOP2B
Pharmacology
KEGGhsa:7155
Structure
PDB3QX3PDB4G0UPDB4G0V
Drugs

What you can answer from here — as of September 07, 2019

56DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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86+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA topoisomerase 2-beta, how selective are they, and which programs against it are still in active trials?

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