Retinoic acid receptor RXR-alpha

Details

Name
Retinoic acid receptor RXR-alpha
Kind
protein
Synonyms
  • NR2B1
  • Nuclear receptor subfamily 2 group B member 1
  • Retinoid X receptor alpha
Gene Name
RXRA
UniProtKB Entry
P19793Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0000821|Retinoic acid receptor RXR-alpha
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
Number of residues
462
Molecular Weight
50810.835
Theoretical pI
7.86
GO Classification
Functions
DNA binding domain binding / DNA-binding transcription factor activity / DNA-binding transcription factor activity, RNA polymerase II-specific / double-stranded DNA binding / identical protein binding / LBD domain binding / nuclear receptor activity / nuclear steroid receptor activity / nuclear vitamin D receptor binding / peptide binding / retinoic acid binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / sequence-specific double-stranded DNA binding / transcription cis-regulatory region binding / transcription coregulator binding
Processes
cell differentiation / hormone-mediated signaling pathway / mRNA transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / positive regulation of bone mineralization / positive regulation of cholesterol efflux / positive regulation of DNA-templated transcription / positive regulation of thyroid hormone mediated signaling pathway / positive regulation of transcription by RNA polymerase II / positive regulation of transporter activity / positive regulation of vitamin D receptor signaling pathway
Components
chromatin / cytosol / mitochondrion / RNA polymerase II transcription regulator complex / transcription regulator complex
General Function
Receptor for retinoic acid that acts as a transcription factor (PubMed:11162439, PubMed:11915042, PubMed:37478846). Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:16107141, PubMed:17761950, PubMed:18800767, PubMed:19167885, PubMed:28167758, PubMed:37478846). The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (PubMed:10195690, PubMed:11162439, PubMed:11915042, PubMed:17761950, PubMed:28167758). The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid (PubMed:1310260). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:20215566). On ligand binding, the corepressors dissociate from the receptors and coactivators are recruited leading to transcriptional activation (PubMed:20215566, PubMed:37478846, PubMed:9267036). Serves as a common heterodimeric partner for a number of nuclear receptors, such as RARA, RARB and PPARA (PubMed:10195690, PubMed:11915042, PubMed:28167758, PubMed:29021580). The RXRA/RARB heterodimer can act as a transcriptional repressor or transcriptional activator, depending on the RARE DNA element context (PubMed:29021580). The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes (PubMed:10195690). Together with RARA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). Acts as an enhancer of RARA binding to RARE DNA element (PubMed:28167758). May facilitate the nuclear import of heterodimerization partners such as VDR and NR4A1 (PubMed:12145331, PubMed:15509776). Promotes myelin debris phagocytosis and remyelination by macrophages (PubMed:26463675). Plays a role in the attenuation of the innate immune system in response to viral infections, possibly by negatively regulating the transcription of antiviral genes such as type I IFN genes (PubMed:25417649). Involved in the regulation of calcium signaling by repressing ITPR2 gene expression, thereby controlling cellular senescence (PubMed:30216632)
Specific Function
DNA binding domain binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0000820|1389 bp
ATGGACACCAAACATTTCCTGCCGCTCGATTTCTCCACCCAGGTGAACTCCTCCCTCACC
TCCCCGACGGGGCGAGGCTCCATGGCTGCCCCCTCGCTGCACCCGTCCCTGGGGCCTGGC
ATCGGCTCCCCGGGACAGCTGCATTCTCCCATCAGCACCCTGAGCTCCCCCATCAACGGC
ATGGGCCCGCCTTTCTCGGTCATCAGCTCCCCCATGGGCCCCCACTCCATGTCGGTGCCC
ACCACACCCACCCTGGGCTTCAGCACTGGCAGCCCCCAGCTCAGCTCACCTATGAACCCC
GTCAGCAGCAGCGAGGACATCAAGCCCCCCCTGGGCCTCAATGGCGTCCTCAAGGTCCCC
GCCCACCCCTCAGGAAACATGGCTTCCTTCACCAAGCACATCTGCGCCATCTGCGGGGAC
CGCTCCTCAGGCAAGCACTATGGAGTGTACAGCTGCGAGGGGTGCAAGGGCTTCTTCAAG
CGGACGGTGCGCAAGGACCTGACCTACACCTGCCGCGACAACAAGGACTGCCTGATTGAC
AAGCGGCAGCGGAACCGGTGCCAGTACTGCCGCTACCAGAAGTGCCTGGCCATGGGCATG
AAGCGGGAAGCCGTGCAGGAGGAGCGGCAGCGTGGCAAGGACCGGAACGAGAATGAGGTG
GAGTCGACCAGCAGCGCCAACGAGGACATGCCGGTGGAGAGGATCCTGGAGGCTGAGCTG
GCCGTGGAGCCCAAGACCGAGACCTACGTGGAGGCAAACATGGGGCTGAACCCCAGCTCG
CCGAACGACCCTGTCACCAACATTTGCCAAGCAGCCGACAAACAGCTTTTCACCCTGGTG
GAGTGGGCCAAGCGGATCCCACACTTCTCAGAGCTGCCCCTGGACGACCAGGTCATCCTG
CTGCGGGCAGGCTGGAATGAGCTGCTCATCGCCTCCTTCTCCCACCGCTCCATCGCCGTG
AAGGACGGGATCCTCCTGGCCACCGGGCTGCACGTCCACCGGAACAGCGCCCACAGCGCA
GGGGTGGGCGCCATCTTTGACAGGGTGCTGACGGAGCTTGTGTCCAAGATGCGGGACATG
CAGATGGACAAGACGGAGCTGGGCTGCCTGCGCGCCATCGTCCTCTTTAACCCTGACTCC
AAGGGGCTCTCGAACCCGGCCGAGGTGGAGGCGCTGAGGGAGAAGGTCTATGCGTCCTTG
GAGGCCTACTGCAAGCACAAGTACCCAGAGCAGCCGGGAAGGTTCGCTAAGCTCTTGCTC
CGCCTGCCGGCTCTGCGCTCCATCGGGCTCAAATGCCTGGAACATCTCTTCTTCTTCAAG
CTCATCGGGGACACACCCATTGACACCTTCCTTATGGAGATGCTGGAGGCGCCGCACCAA
ATGACTTAG
Chromosome Location
9
Locus
9q34.2
External Identifiers
ResourceLink
UniProtKB IDP19793
UniProtKB Entry NameRXRA_HUMAN
GenBank Protein ID35885
GenBank Gene IDX52773
GeneCard IDRXRA
GenAtlas IDRXRA
HGNC IDHGNC:10477
PDB ID(s)1BY4, 1DSZ, 1FBY, 1FM6, 1FM9, 1G1U, 1G5Y, 1K74, 1MV9, 1MVC, 1MZN, 1R0N, 1RDT, 1RXR, 1XLS, 1XV9, 1XVP, 1YNW, 2ACL, 2NLL, 2P1T, 2P1U, 2P1V, 2ZXZ, 2ZY0, 3DZU, 3DZY, 3E00, 3E94, 3FAL, 3FC6, 3FUG, 3H0A, 3KWY, 3NSP, 3NSQ, 3OAP, 3OZJ, 3PCU, 3R29, 3R2A, 3R5M, 3UVV, 4CN2, 4CN3, 4CN5, 4CN7, 4J5W, 4J5X, 4K4J, 4K6I, 4M8E, 4M8H, 4N5G, 4N8R, 4NQA, 4OC7, 4POH, 4POJ, 4PP3, 4PP5, 4RFW, 4RMC, 4RMD, 4RME, 4ZO1, 4ZSH, 5EC9, 5JI0, 5LYQ, 5MJ5, 5MK4, 5MKJ, 5MKU, 5MMW, 5TBP, 5UAN, 5Z12, 5ZQU, 6A5Y, 6A5Z, 6A60, 6FBQ, 6FBR, 6HN6, 6JNO, 6JNR, 6L6K, 6LB4, 6LB5, 6LB6, 6SJM, 6STI, 6XWG, 6XWH, 7A77, 7B88, 7B9O, 7BK4, 7CFO, 7NKE, 7UW2, 7UW4, 8HBM, 8PP0
KEGG IDhsa:6256
IUPHAR/Guide To Pharmacology ID610
NCBI Gene ID6256
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
AcitretinapprovedyestargetagonistDetails
Alitretinoinapproved, investigationalyestargetagonistDetails
EtretinatewithdrawnyestargetagonistDetails
EVT-101investigationalunknowntargetDetails
Etodolacapproved, investigational, vet_approvedunknowntargetotherDetails
Bexaroteneapproved, investigationalyestargetagonistDetails
3,20-PregnanedioneexperimentalyestargetinhibitorDetails
2-chloro-5-nitro-N-phenylbenzamideexperimentalyestargetinhibitorDetails
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONEexperimentalunknowntargetDetails
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDexperimentalunknowntargetDetails
TributyltinexperimentalyestargetinhibitorDetails
Doconexentapproved, investigationalyestargetactivatorDetails
Arachidonic AcidexperimentalunknowntargetDetails
alpha-Linolenic acidapproved, investigational, nutraceuticalunknowntargetDetails
Oleic Acidapproved, investigational, vet_approvedunknowntargetDetails
Tretinoinapproved, investigational, nutraceuticalunknowntargetagonistDetails
Alfacalcidolapproved, nutraceuticalunknowntargetDetails
Bezafibrateapproved, investigationalunknowntargetagonistDetails
Phthalic AcidexperimentalunknowntargetDetails
Rosiglitazoneapproved, investigationalunknowntargetDetails
AdapaleneapprovedyestargetagonistDetails