Retinoic acid receptor RXR-alpha

BE0000412ProteinHumansRXRA

Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846). It is acted on by 25 drugs in DrugBank.

Gene name
RXRA
UniProtKB entry
P19793Swiss-Prot
Cellular location
Nucleus
Residues / weight
462 residues · 50,811 Da
Also known as
NR2B1 · Nuclear receptor subfamily 2 group B member 1 · Retinoid X receptor alpha

Resolves to

Protein
UniProtP19793UniProt nameRXRA_HUMAN
Gene
HGNCHGNC:10477NCBI Gene6256GenBank35885GeneCardsRXRA
Pharmacology
IUPHAR/GtoPdb610KEGGhsa:6256
Structure
PDB1BY4PDB1DSZPDB1FBY
Drugs

What you can answer from here — as of September 07, 2019

25DrugsApproved to experimental, with action, bond type and pharmacological action
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45GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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107+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Retinoic acid receptor RXR-alpha, how selective are they, and which programs against it are still in active trials?

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