Anti-Inflammatory Agents, Non-Steroidal
- Anti-Inflammatory Agents, Non-Steroidal
- Accession Number
- DBCAT000049 (DBCAT000421, DBCAT002309, DBCAT003329, DBCAT004093)
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
- ATC Classification
Drug Drug Description Ketorolac An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Flurbiprofen An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Bromfenac An NSAID used to treat postoperative pain and inflammation of the eye. Nepafenac An ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Indomethacin A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. Nabumetone An NSAID used to treat osteoarthritis and rheumatoid arthritis. Tenoxicam An anti inflammatory analgesic used to treat mild to moderate pain as well as the signs and symptoms of rheumatoid arthritis and osteoarthritis. Celecoxib An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. Tolmetin An NSAID used to treat acute flares of various painful conditions and used for the long term management of osteoarthritis, rheumatoid arthritis, and juvenile arthritis. Rofecoxib A COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks. Piroxicam An NSAID used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Fenoprofen An anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. Valdecoxib A COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea. Sulindac An NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. Etodolac An NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. Mefenamic acid An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. Naproxen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. Sulfasalazine An anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis. Phenylbutazone An NSAID used to treat backache and ankylosing spondylitis. Meloxicam An NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. Carprofen For use as a pain reliever in the treatment of joint pain and post-surgical pain. Diflunisal An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. Suprofen An NSAID used to prevent pupil constriction in ocular surgery. Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Meclofenamic acid An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. Acetylsalicylic acid A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. Oxaprozin An NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Ketoprofen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. Balsalazide An aminosalicylate used to treat ulcerative colitis. Ibuprofen An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. Olsalazine An anti-inflammatory agent used in the treatment of inflammatory bowel disease and ulcerative colitis. Lumiracoxib For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults. Magnesium salicylate An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain. Salsalate A nonsteroidal anti-inflammatory agent used in the symptomatic relief of rheumatoid arthritis, osteoarthritis and related rheumatic disorders. Choline magnesium trisalicylate Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults. Antipyrine An antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine. Tiaprofenic acid A nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. Etoricoxib For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain and gout. Oxyphenbutazone A nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain. Niflumic acid Used in the treatment of rheumatoid arthritis. Nimesulide For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Benoxaprofen The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets... Metamizole Used in the past as a powerful painkiller and fever reducer. Zomepirac Zomepirac was indicated for the management of mild to severe pain. Lornoxicam For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases. Aceclofenac Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Zaltoprofen A non-steroidal anti-inflammatory drug approved for use in Japan in 1993. Azapropazone Not Available Felbinac Not Available Parecoxib A selective COX-2 inhibitor and NSAID used for the short-term management of perioperative pain. Salicylamide Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... Kebuzone Kebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug. Isoxicam Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States. Indoprofen A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. Ibuproxam Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). Floctafenine An anti-inflammatory analgesic used to manage mild to moderate acute pain. Fenbufen Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is... Etofenamate Etofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID). Epirizole Epirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain. Loxoprofen Loxoprofen is non-steroidal anti-inflammatory medication (NSAID) indicated for pain and inflammation related to musculoskeletal and joint disorders. In addition to its effects on pain, it is an antipyretic and anti-inflammatory... Droxicam Droxicam is an NSAID previously used for the treatment of inflammation and rheumatoid arthritis . Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Clonixin Indicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. Propacetamol Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. Tepoxalin Tepoxalin is a nonsteroidal anti-inflammatory drug approved for veterinary use in the United States and many other countries. It is primarily used to reduce inflammation and relief of pain caused... Flunixin Flunixin is a non-steroidal anti-inflammatory drug for use in pigs, cattle and horses. It exerts analgesic and antipyretic effects. This drug is often prepared for use in meglumine salt form.... Indobufen Indobufen has been used in trials studying the supportive care and prevention of Atrial Fibrillation. Tinoridine Tinoridine is under investigation in clinical trial NCT01224756 (Efficacy of Tinoridine in Treating Pain and Inflammation in Adults). Alclofenac Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies. Fentiazac Not Annotated Suxibuzone Not Annotated Bumadizone Bumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis... Alminoprofen Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances. Flunoxaprofen Not Annotated Bufexamac An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. Feprazone Not Annotated Difenpiramide Not Annotated Nifenazone Not Annotated Lonazolac Not Annotated Tenidap Not Annotated Bendazac Prior to the withdrawal of bendazac from various international regions of use due to concerns for hepatotoxicity [A39891, A39892, A39893, L4778] the chemical had demonstrated potential usefulness predominantly as the... Pranoprofen Not Annotated Propyphenazone Not Annotated Proglumetacin Not Annotated Guacetisal Not Annotated Ethenzamide Not Annotated Carbaspirin calcium Not Annotated Mofebutazone Not Annotated Proquazone Not Annotated Benorilate Not Annotated Pirprofen Not Annotated Acemetacin Acemetacin is not FDA, Canada or EMA approved, but in the countries where it is marketed it is indicated for the symptomatic treatment of pain and swelling in acute inflammation... Imidazole salicylate Not Annotated Benzydamine A locally-acting NSAID indicated for the symptomatic relief of pain in acute sore throat and for the symptomatic relief of oropharyngeal mucositis caused by radiation therapy. Icosapent A polyunsaturated fatty acid, usually found in fish oils, that is used in many supplements. Antrafenine Antrafenine is used as an anti-inflammatory and analgesic agent for the relief of mild to moderate pain. Dexibuprofen For more information, refer to ibuprofen. Trolamine salicylate A medication used to relieve minor aches and pains of the muscles and joints. Cimicoxib Investigated for use/treatment in depression. Robenacoxib Robenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs. Aminophenazone Formerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds. Currently used to measure total body water. Mesalazine An aminosalicylate drug used to treat mild to moderate active ulcerative colitis and also to maintain remission once achieved. SC-236 SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , , , . NS-398 NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases. Firocoxib Used for the treatment of pain inflammation and fever in horses and dogs. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. Morniflumate Morniflumate is indicated for the treatment of inflammatory conditions affecting the airways, ENT system, urogenital tract and bone and joint systems in adults. In Italy, morniflumate is also indicated for... Talniflumate Talnifumate is a phthalidyl ester of nifumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis and osteoarthritis ,... Dexketoprofen For short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache . Taxifolin Not Available Betulinic Acid Betulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome. Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Flurbiprofen axetil Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients). Polmacoxib Polmacoxib has been used in trials studying the treatment of Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Localized Primary Osteoarthritis of Hip, and Localized Primary Osteoarthritis of Knee. Licofelone For the management of osteoarthritis. Ursolic acid Not Annotated Fepradinol Not Annotated Peoniflorin Peoniflorin is under investigation in clinical trial NCT02878863 (Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis). Rezafungin Rezafungin is under investigation in clinical trial NCT04368559 (Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation). Veliflapon Veliflapon is under investigation in clinical trial NCT00353067 (Veliflapon (Dg-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina).
- Drugs & Drug Targets