Anti-Inflammatory Agents, Non-Steroidal
- Name
- Anti-Inflammatory Agents, Non-Steroidal
- Accession Number
- DBCAT000049 (DBCAT000421, DBCAT002309, DBCAT003329, DBCAT004093)
- Description
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
- ATC Classification
- Drugs
Drug Drug Description Aceclofenac Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Acemetacin A NSAID indicated in the treatment of pain and inflammation. Acetylsalicylic acid A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. Alclofenac Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies. Alminoprofen Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances. Aminophenazone An analgesic drug used to treat acute migraine attacks in combination with ergotamine and caffeine. Amiprilose Amiprilose is a small molecule drug. Amiprilose has a monoisotopic molecular weight of 305.18 Da. Antipyrine An antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine. Antrafenine Antrafenine is used as an anti-inflammatory and analgesic agent for the relief of mild to moderate pain. Azapropazone Not Available Balsalazide An aminosalicylate used to treat ulcerative colitis. Bendazac A non-steroidal anti-inflammatory drug (NSAID) available as an eye drop for the treatment of cataracts and as a topical cream for the treatment of dermatitis, eczema, hives, skin ulcers and other inflammatory skin conditions. Benorilate Not Annotated Benoxaprofen The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets... Benzydamine A locally-acting NSAID indicated for the symptomatic relief of pain in acute sore throat and for the symptomatic relief of oropharyngeal mucositis caused by radiation therapy. Berbamine Not Annotated Betulinic Acid Betulinic Acid has been used in trials studying the treatment of Dysplastic Nevus Syndrome. Bromfenac An NSAID used to treat postoperative pain and inflammation of the eye. Bufexamac An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. Bumadizone Bumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis... Carbaspirin calcium An NSAID indicated in the treatment of short term pain and fever. Carprofen For use as a pain reliever in the treatment of joint pain and post-surgical pain. Caryophyllene Not Annotated Celecoxib An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. Cepharanthine Not Annotated Choline magnesium trisalicylate Choline magnesium trisalicylate is used to reduce pain and inflammation caused by conditions such as arthritis. This medication is also used to treat fever in adults. Cimicoxib Investigated for use/treatment in depression. Clonixin An NSAID used to relieve pain associated with arthritis, migraines, and various soft tissue disorders. CP-96345 Not Annotated Crisdesalazine Not Annotated Deracoxib Deracoxib is a non-steroidal anti-inflammatory drug of the coxib class, used in veterinary medicine to treat osteoarthritis in dogs. It is sold in tablets, which have added beefy flavour to... Deupirfenidone Deupirfenidone is under investigation in clinical trial NCT05321420 (LYT-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF)). Dexibuprofen A pharmacologically active enantiomer of racemic ibuprofen (NSAID) used to treat pain and inflammation. Dexketoprofen An NSAID that is the R(-)-enantiomer of racemic ketoprofen with analgesic and anti-inflammatory properties used for the treatment of mild to moderate pain. Diclofenac An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Difenpiramide Not Annotated Diflunisal An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. Droxicam Droxicam is an NSAID previously used for the treatment of inflammation and rheumatoid arthritis . Ebselen Ebselen has been investigated for the treatment and basic science of Meniere's Disease, Type 2 Diabetes Mellitus, and Type 1 Diabetes Mellitus. Eltenac Eltenac is a small molecule drug. The usage of the INN stem '-ac' in the name indicates that Eltenac is a anti-inflammatory agent, ibufenac derivative. Eltenac has a monoisotopic molecular... Enfenamic acid Enfenamic acid is a small molecule drug. Enfenamic acid has a monoisotopic molecular weight of 241.11 Da. Epirizole Epirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain. Ethenzamide Not Annotated Etodolac An NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain. Etofenamate An NSAID used to treat muscle and joint pain. Etoricoxib A selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis. Famprofazone Famprofazone is a nonsteroidal anti-inflammatory agent found in combination products such as ‘Gewodin’ which is marketed in Taiwan. It is important to note that the drug is metabolized to methamphetamine... Felbinac Not Available Fenbufen Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is... Fenclofenac Fenclofenac is a small molecule drug. The usage of the INN stem '-ac' in the name indicates that Fenclofenac is a anti-inflammatory agent, ibufenac derivative. Fenclofenac has a monoisotopic molecular... Fenflumizole Fenflumizole is a small molecule drug. Fenflumizole has a monoisotopic molecular weight of 392.13 Da. Fenoprofen An anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis. Fentiazac Not Annotated Fepradinol Not Annotated Feprazone Not Annotated Firocoxib Used for the treatment of pain inflammation and fever in horses and dogs. Floctafenine An anti-inflammatory analgesic used to manage mild to moderate acute pain. Flosulide Flosulide is a small molecule drug. Flosulide has a monoisotopic molecular weight of 353.05 Da. Flunixin Flunixin is a non-steroidal anti-inflammatory drug for use in pigs, cattle and horses. It exerts analgesic and antipyretic effects. This drug is often prepared for use in meglumine salt form.... Flunoxaprofen Not Annotated Flurbiprofen An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Flurbiprofen axetil Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients). Glycol salicylate A salicylate used to treat mild to moderate muscle pain. Guacetisal Not Annotated Ibuprofen An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. Ibuproxam Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). Icosapent A polyunsaturated fatty acid, usually found in fish oils, that is used in many supplements. Imidazole salicylate Not Annotated Indobufen A reversible platelet aggregation inhibitor used to prevent coronary and peripheral artery occlusion. Indomethacin A nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants. Indoprofen A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. Isoxicam Isoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States. Kebuzone Kebuzone (also known as ketophenylbutazone ) is a non-steroidal anti-inflammatory drug. Ketoprofen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain. Ketorolac An NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches. Licofelone For the management of osteoarthritis. Lonazolac Not Annotated Lornoxicam An NSAID indicated in the treatment of mild to moderate pain, as well as rheumatoid arthritis and osteoarthritis. Loxoprofen An NSAID used to treat pain and inflammation in musculoskeletal conditions. Lumiracoxib For the acute and chronic treatment of the signs and symptoms of osteoarthritis of the knee in adults. Magnesium salicylate An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain. Meclofenamic acid An NSAID used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. Mefenamic acid An NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. Meloxicam An NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. Menthyl salicylate For the temporary relief of pain associated with rheumatism, arthritis, neuralgia, sprains and strains of joints and muscles, lumbago and fibrositis . Mofebutazone Not Annotated Mofezolac Mofezolac is a small molecule drug. The usage of the INN stem '-ac' in the name indicates that Mofezolac is a anti-inflammatory agent, ibufenac derivative. Mofezolac has a monoisotopic molecular... Morniflumate An NSAID derived from niflumic acid used in the symptomatic treatment of inflammatory conditions of the airways, ENT, and the urogenital and osteoarticular systems. Nabumetone An NSAID used to treat osteoarthritis and rheumatoid arthritis. Naproxen An NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain. Nepafenac An ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Nifenazone Not Annotated Niflumic acid A cyclooxygenase-2 inhibitor used to alleviate inflammation, pain, and edema associated with acute and chronic inflammatory conditions, such as rheumatoid arthritis, osteoarthritis, post-operative inflammatory conditions, and physical trauma. Nimesulide A cyclooxygenase 2 inhibitor used to treat acute pain and primary dysmenorrhea. Nitroaspirin Nitroaspirin has been investigated for the treatment of Intermittent Claudication. NS-398 NS-398 is a COX-2 inhibitor. It was developed as part of the mechanistic study of the cyclooxygenases. Oxaprozin An NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Oxyphenbutazone A nonsteroidal anti-inflammatory drug (NSAID) no longer commonly used for the symptomatic relief of musculoskeletal pain. Parecoxib A selective COX-2 inhibitor and NSAID used for the short-term management of perioperative pain. Peoniflorin Peoniflorin is under investigation in clinical trial NCT02878863 (Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis). Phenylbutazone An NSAID used to treat backache and ankylosing spondylitis. Piroxicam An NSAID used to treat the symptoms of osteoarthritis and rheumatoid arthritis. Pirprofen Not Annotated Polmacoxib Polmacoxib has been used in trials studying the treatment of Osteoarthritis, Osteoarthritis, Hip, Osteoarthritis, Knee, Localized Primary Osteoarthritis of Hip, and Localized Primary Osteoarthritis of Knee. Pranoprofen A topical anti-inflammatory agent used for the treatment of non-infectious inflammatory conditions such as blepharitis and conjunctivitis. Pranoprofen ophthalmic solution may also be used post-operatively to manage inflammation. Proglumetacin A non-steroidal anti-inflammatory medication used to manage pain associated with various inflammatory conditions including rheumatoid arthritis and osteoarthritis. Propacetamol Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. Propyphenazone Propyphenazone is a non-steroidal anti-inflammatory agent with analgesic effects. Proquazone Not Annotated Robenacoxib Robenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs. Rofecoxib A COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks. Rosmarinic acid Not Annotated Salicin Not Annotated Salicylamide Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salsalate A nonsteroidal anti-inflammatory agent used in the symptomatic relief of rheumatoid arthritis, osteoarthritis and related rheumatic disorders. SC 41930 Not Annotated SC-236 SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , , , . Senlizumab Not Annotated Sulfasalazine A salicylate used to treat Crohn's disease, ulcerative colitis, and rheumatoid arthritis. Sulindac An NSAID used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute subacromial bursitis or supraspinatus tendinitis, and acute gouty arthritis. Suprofen An NSAID used to prevent pupil constriction in ocular surgery. Suxibuzone Not Annotated Talniflumate Talnifumate is a phthalidyl ester of nifumic acid, which has potent analgesic and anti-inflammatory effects and is widely used to treat inflammatory disorders, such as rheumatoid arthritis and osteoarthritis ,... Tanshinone I Not Annotated Taxifolin Not Available Tenidap Not Annotated Tenoxicam An anti inflammatory analgesic used to treat mild to moderate pain as well as the signs and symptoms of rheumatoid arthritis and osteoarthritis. Tepoxalin Tepoxalin is a nonsteroidal anti-inflammatory drug approved for veterinary use in the United States and many other countries. It is primarily used to reduce inflammation and relief of pain caused... Tiaprofenic acid A nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. Tiaramide Tiaramide is a small molecule drug. Tiaramide has a monoisotopic molecular weight of 355.08 Da. Tinoridine Tinoridine is under investigation in clinical trial NCT01224756 (Efficacy of Tinoridine in Treating Pain and Inflammation in Adults). Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Tolmetin An NSAID used to treat acute flares of various painful conditions and used for the long term management of osteoarthritis, rheumatoid arthritis, and juvenile arthritis. Trolamine salicylate A medication used to relieve minor aches and pains of the muscles and joints. Ursolic acid Not Annotated Valdecoxib A COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea. Veliflapon Veliflapon is under investigation in clinical trial NCT00353067 (Veliflapon (Dg-031)to Prevent Heart Attacks or Stroke in Patients With a History of Heart Attack or Unstable Angina). Zaltoprofen A non-steroidal anti-inflammatory drug approved for use in Japan in 1993. Zomepirac Zomepirac was indicated for the management of mild to severe pain.