Neuronal acetylcholine receptor subunit beta-2

BE0000850ProteinHumansCHRNB2

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate... It is acted on by 28 drugs in DrugBank.

Gene name
CHRNB2
UniProtKB entry
P17787Swiss-Prot
Cellular location
Synaptic cell membrane
Residues / weight
502 residues · 57,019 Da

Resolves to

Protein
UniProtP17787UniProt nameACHB2_HUMAN
Gene
HGNCHGNC:1962NCBI Gene1141GenBank32017GeneCardsCHRNB2
Pharmacology
KEGGhsa:1141
Structure
PDB2K58PDB2K59PDB2KSR
Drugs

What you can answer from here — as of September 07, 2019

28DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuronal acetylcholine receptor subunit beta-2, how selective are they, and which programs against it are still in active trials?

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