Neuronal acetylcholine receptor subunit alpha-4

BE0000849ProteinHumansCHRNA4

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate... It is acted on by 51 drugs in DrugBank.

Gene name
CHRNA4
UniProtKB entry
P43681Swiss-Prot
Cellular location
Synaptic cell membrane
Residues / weight
627 residues · 69,956 Da
Also known as
NACRA4

Resolves to

Protein
UniProtP43681UniProt nameACHA4_HUMAN
Gene
HGNCHGNC:1958NCBI Gene1137GenBank755648GeneCardsCHRNA4
Pharmacology
IUPHAR/GtoPdb465KEGGhsa:1137
Structure
PDB2LLYPDB5KXIPDB6CNJ
Drugs

What you can answer from here — as of September 07, 2019

51DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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121+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuronal acetylcholine receptor subunit alpha-4, how selective are they, and which programs against it are still in active trials?

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