Beta-1 adrenergic receptor

BE0000172ProteinHumansADRB1

G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway (PubMed:10212248, PubMed:12391161, PubMed:15358775). It is acted on by 90 drugs in DrugBank.

Gene name
ADRB1
UniProtKB entry
P08588Swiss-Prot
Cellular location
Cell membrane
Residues / weight
477 residues · 51,223 Da
Also known as
ADRB1R · B1AR · Beta-1 adrenoceptor · Beta-1 adrenoreceptor

Resolves to

Protein
UniProtP08588UniProt nameADRB1_HUMAN
Gene
HGNCHGNC:285NCBI Gene153GenBank178200GeneCardsADRB1
Pharmacology
IUPHAR/GtoPdb28KEGGhsa:153
Structure
PDB2LSQPDB7BTSPDB7BU6
Drugs

What you can answer from here — as of September 07, 2019

90DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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307+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta-1 adrenergic receptor, how selective are they, and which programs against it are still in active trials?

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