5-hydroxytryptamine receptor 1A

BE0000291ProteinHumansHTR1A

G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041). It is acted on by 131 drugs in DrugBank.

Gene name
HTR1A
UniProtKB entry
P08908Swiss-Prot
Cellular location
Cell membrane
Residues / weight
422 residues · 46,106 Da
Also known as
5-HT-1A · 5-HT1A · ADRB2RL1 · ADRBRL1 · G-21

Resolves to

Protein
UniProtP08908UniProt name5HT1A_HUMAN
Gene
HGNCHGNC:5286NCBI Gene3350GenBank189928GeneCardsHTR1A
Pharmacology
IUPHAR/GtoPdb1KEGGhsa:3350
Structure
PDB7E2XPDB7E2YPDB7E2Z
Drugs

What you can answer from here — as of September 07, 2019

131DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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441+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-hydroxytryptamine receptor 1A, how selective are they, and which programs against it are still in active trials?

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