Beta-3 adrenergic receptor

BE0001012ProteinHumansADRB3

G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively (PubMed:10188996, PubMed:2570461, PubMed:8641219). It is acted on by 43 drugs in DrugBank.

Gene name
ADRB3
UniProtKB entry
P13945Swiss-Prot
Cellular location
Cell membrane
Residues / weight
408 residues · 43,519 Da
Also known as
ADRB3R · B3AR · Beta-3 adrenoceptor · Beta-3 adrenoreceptor

Resolves to

Protein
UniProtP13945UniProt nameADRB3_HUMAN
Gene
HGNCHGNC:288NCBI Gene155GenBank178896GeneCardsADRB3
Pharmacology
IUPHAR/GtoPdb30KEGGhsa:155
Structure
PDB9IJDPDB9IJE
Drugs

What you can answer from here — as of September 07, 2019

43DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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90+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta-3 adrenergic receptor, how selective are they, and which programs against it are still in active trials?

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