Neuronal acetylcholine receptor subunit alpha-3

BE0003585ProteinHumansCHRNA3

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate... It is acted on by 17 drugs in DrugBank.

Gene name
CHRNA3
UniProtKB entry
P32297Swiss-Prot
Cellular location
Synaptic cell membrane
Residues / weight
505 residues · 57,480 Da
Also known as
NACHRA3

Resolves to

Protein
UniProtP32297UniProt nameACHA3_HUMAN
Gene
HGNCHGNC:1957NCBI Gene1136GenBank177898GeneCardsCHRNA3
Pharmacology
IUPHAR/GtoPdb464KEGGhsa:1136
Structure
PDB4ZK4PDB5SYOPDB5TVC
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuronal acetylcholine receptor subunit alpha-3, how selective are they, and which programs against it are still in active trials?

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