Gamma-aminobutyric acid receptor subunit gamma-3

BE0003594ProteinHumansGABRG3

Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). It is acted on by 27 drugs in DrugBank.

Gene name
GABRG3
UniProtKB entry
Q99928Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
467 residues · 54,288 Da
Also known as
GABA(A) receptor subunit gamma-3 · GABAAR subunit gamma-3

Resolves to

Protein
UniProtQ99928UniProt nameGBRG3_HUMAN
Gene
HGNCHGNC:4088NCBI Gene2567GenBank1754749GeneCardsGABRG3
Pharmacology
KEGGhsa:2567
Drugs

What you can answer from here — as of September 07, 2019

27DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit gamma-3, how selective are they, and which programs against it are still in active trials?

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