Gamma-aminobutyric acid receptor subunit alpha-1

BE0000795ProteinHumansGABRA1

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725, PubMed:30602789). It is acted on by 59 drugs in DrugBank.

Gene name
GABRA1
UniProtKB entry
P14867Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
456 residues · 51,801 Da
Also known as
GABA(A) receptor subunit alpha-1 · GABAAR subunit alpha-1

Resolves to

Protein
UniProtP14867UniProt nameGBRA1_HUMAN
Gene
HGNCHGNC:4075NCBI Gene2554GenBank31631GeneCardsGABRA1
Pharmacology
IUPHAR/GtoPdb404KEGGhsa:2554
Structure
PDB6CDUPDB6D1SPDB6D6T
Drugs

What you can answer from here — as of September 07, 2019

59DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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199+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit alpha-1, how selective are they, and which programs against it are still in active trials?

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