ATP-sensitive inward rectifier potassium channel 11

BE0000708ProteinHumansKCNJ11

Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells (PubMed:29286281, PubMed:34815345). It is acted on by 13 drugs in DrugBank.

Gene name
KCNJ11
UniProtKB entry
Q14654Swiss-Prot
Cellular location
Membrane
Residues / weight
390 residues · 43,525 Da
Also known as
IKATP · Inward rectifier K(+) channel Kir6.2 · Potassium channel, inwardly rectifying subfamily J member 11

Resolves to

Protein
UniProtQ14654UniProt nameKCJ11_HUMAN
Gene
HGNCHGNC:6257NCBI Gene3767GenBank1088445GeneCardsKCNJ11
Pharmacology
KEGGhsa:3767
Structure
PDB6C3OPDB6C3PPDB7S5T
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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69+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-sensitive inward rectifier potassium channel 11, how selective are they, and which programs against it are still in active trials?

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