Multidrug and toxin extrusion protein 1

BE0003657ProteinHumansSLC47A1

Multidrug efflux pump that functions as a H(+)/organic cation antiporter (PubMed:16330770, PubMed:17509534). It is acted on by 107 drugs in DrugBank.

Gene name
SLC47A1
UniProtKB entry
Q96FL8Swiss-Prot
Cellular location
Cell membrane
Residues / weight
570 residues · 61,922 Da
Also known as
hMATE-1 · MATE-1 · MATE1 · Solute carrier family 47 member 1

Resolves to

Protein
UniProtQ96FL8UniProt nameS47A1_HUMAN
Gene
HGNCHGNC:25588NCBI Gene55244GenBank7023138GeneCardsSLC47A1
Pharmacology
IUPHAR/GtoPdb1216KEGGhsa:55244
Structure
PDB9R10PDB9R1EPDB9R1F
Drugs

What you can answer from here — as of September 07, 2019

107DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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159+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Multidrug and toxin extrusion protein 1, how selective are they, and which programs against it are still in active trials?

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