Multidrug and toxin extrusion protein 2

BE0004752ProteinHumansSLC47A2

Multidrug efflux pump that functions as a H(+)/organic cation antiporter. It is acted on by 76 drugs in DrugBank.

Gene name
SLC47A2
UniProtKB entry
Q86VL8Swiss-Prot
Cellular location
Cell membrane
Residues / weight
602 residues · 65,084 Da
Also known as
hMATE-2 · Kidney-specific H(+)/organic cation antiporter · MATE-2 · MATE2 · Solute carrier family 47 member 2

Resolves to

Protein
UniProtQ86VL8UniProt nameS47A2_HUMAN
Gene
HGNCHGNC:26439NCBI Gene146802GeneCardsSLC47A2
Pharmacology
IUPHAR/GtoPdb1217KEGGhsa:146802
Drugs

What you can answer from here — as of September 07, 2019

76DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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119+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Multidrug and toxin extrusion protein 2, how selective are they, and which programs against it are still in active trials?

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