(+)-Mefloquine
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Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- (+)-Mefloquine
- DrugBank Accession Number
- DB05636
- Background
(+)-Mefloquine was under investigation in clinical trial NCT00931697 (Study to Investigate the Safety, Tolerability and Pharmacokinetics of AD 452 (+)-Mefloquine Compared With Racemic Mefloquine) to compare the efficacy of (+) Mefloquine vs. racemic Mefloquine.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 378.318
Monoisotopic: 378.116682121 - Chemical Formula
- C17H16F6N2O
- Synonyms
- (+)-(11R,2'S)-erythro-mefloquine
- (+)-mefloquine
- [(11R,2'S)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol
- External IDs
- AD 452
- AD-452
- AD452
Pharmacology
- Indication
Investigated for use/treatment in rheumatoid arthritis.
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- 51688-68-7
- InChI Key
- XEEQGYMUWCZPDN-SWLSCSKDSA-N
- InChI
- InChI=1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2/t12-,15+/m0/s1
- IUPAC Name
- SMILES
- O[C@@H]([C@@H]1CCCCN1)C1=CC(=NC2=C(C=CC=C12)C(F)(F)F)C(F)(F)F
References
- General References
- Not Available
- External Links
- ChemSpider
- 401792
- BindingDB
- 50377446
- ChEBI
- 63684
- ChEMBL
- CHEMBL411329
- ZINC
- ZINC000000897089
- PDBe Ligand
- YMZ
- PDB Entries
- 5umd / 5zni / 7dia / 8f51 / 8jwf / 8jwg / 8qoj
Clinical Trials
- Clinical Trials
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Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data2 Completed Treatment Rheumatoid Arthritis 1 somestatus stop reason just information to hide 1 Completed Treatment Healthy Volunteers (HV) 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at November 18, 2007 18:26 / Updated at July 13, 2024 15:36