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(+)-Mefloquine

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Identification

Generic Name
(+)-Mefloquine
DrugBank Accession Number
DB05636
Background

(+)-Mefloquine was under investigation in clinical trial NCT00931697 (Study to Investigate the Safety, Tolerability and Pharmacokinetics of AD 452 (+)-Mefloquine Compared With Racemic Mefloquine) to compare the efficacy of (+) Mefloquine vs. racemic Mefloquine.

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 378.318
Monoisotopic: 378.116682121
Chemical Formula
C17H16F6N2O
Synonyms
  • (+)-(11R,2'S)-erythro-mefloquine
  • (+)-mefloquine
  • [(11R,2'S)-2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol
External IDs
  • AD 452
  • AD-452
  • AD452
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Pharmacology

Indication

Investigated for use/treatment in rheumatoid arthritis.

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
51688-68-7
InChI Key
XEEQGYMUWCZPDN-SWLSCSKDSA-N
InChI
InChI=1S/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2/t12-,15+/m0/s1
IUPAC Name
SMILES
O[C@@H]([C@@H]1CCCCN1)C1=CC(=NC2=C(C=CC=C12)C(F)(F)F)C(F)(F)F

References

General References
Not Available
ChemSpider
401792
BindingDB
50377446
ChEBI
63684
ChEMBL
CHEMBL411329
ZINC
ZINC000000897089
PDBe Ligand
YMZ
PDB Entries
5umd / 5zni / 7dia / 8f51 / 8jwf / 8jwg / 8qoj

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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2CompletedTreatmentRheumatoid Arthritis1somestatusstop reasonjust information to hide
1CompletedTreatmentHealthy Volunteers (HV)1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at November 18, 2007 18:26 / Updated at July 13, 2024 15:36