DPI-221

DB06121ExperimentalSmall molecule

DPI-221 is an investigational drug and a selective agonist for the δ-opioid receptor.

Mechanism: The opioid receptor system constitutes three receptor subtypes, {delta}, µ, and {kappa}, and all three receptors play a role in bladder control and micturition events. There is a growing volume of information supporting a role for the {delta} receptor in these processes. DPI-221 is an opioid {delta} receptor agonist.
Curator reviewed
Primary indication: Investigated for use/treatment in urinary incontinence.Curator reviewed
Formula / weight: C₃₁H₃₈FN₃O · 487.663 g/mol (avg)
Also known as: 4-((.ALPHA.S)-.ALPHA.-((2S,5R)-2,5-DIMETHYL-4-(3-FLUOROBENZYL)-1-PIPERAZINYL)BENZYL)-N,N-DIETHYLBENZAMIDE · BENZAMIDE, N,N-DIETHYL-4-((S)-((2S,5R)-4-((3-FLUOROPHENYL)METHYL)-2,5-DIMETHYL-1-PIPERAZINYL)PHENYLMETHYL)- · N,N-DIETHYL-4-((S)-((2S,5R)-4-((3-FLUOROPHENYL)METHYL)-2,5-DIMETHYL-1-PIPERAZINYL)PHENYLMETHYL)BENZAMIDE
Code names: DPI-221

Resolves to

Compound

Structure

InChIKeyKEXJLZMJVOTFOY-QEGDFHJFSA-NSMILES[H][C@](N1C[C@@]([H])(C)N(CC2=CC(F)=CC=C2)C[C@]1([H])C)(C1=CC=CC=C1)C1=CC=C(C=C1)C(=O)N(CC)CC

Targets

What you can answer from here — as of April 02, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with DPI-221, and which of those have an active Phase 3 trial?

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