ISF402

DB06315ExperimentalSmall molecule

ISF402 is an investigational peptide tetramer which helps dispersal of insulin via zinc chelation, therefore allowing insulin hexamers to break free.

Mechanism: Insulin is released from the pancreas as hexamers. ISF402, a naturally occurring peptide tetramer, helps dispersal of insulin by allowing the insulin molecules to break free. As single molecules, the insulin is immediately available to bind to receptors on the liver, signalling the liver to take up and store sugar molecules from the blood. ISF402 also amplifies the signal generated by the receptors so that less insulin is needed for the liver's response. [Dia B Tech Website]
Curator reviewed
Primary indication: Investigated for use/treatment in diabetes mellitus type 2.Curator reviewed
Formula / weight: C₁₉H₃₁N₇O₇ · 469.499 g/mol (avg)
Code names: ISF402

Resolves to

Compound

CAS484649-95-8

Structure

InChIKeyBYWLSTFTCYEFLE-GIEZYDSUSA-NSMILES[H][C@](C)(O)[C@]([H])(\N=C(/O)[C@]([H])(CC1=CN=CN1)\N=C(/O)[C@@]([H])(N)C(C)C)C(\O)=N\[C@@]([H])(CC(O)=N)C(O)=O

Targets

P01308INS

What you can answer from here — as of April 02, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with ISF402, and which of those have an active Phase 3 trial?

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