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ISF402

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Identification

Generic Name
ISF402
DrugBank Accession Number
DB06315
Background

ISF402 is an investigational peptide tetramer which helps dispersal of insulin via zinc chelation, therefore allowing insulin hexamers to break free.

Type
Small Molecule
Groups
Investigational
Structure
Similar Structures
Weight
Average: 469.499
Monoisotopic: 469.228496366
Chemical Formula
C19H31N7O7
Synonyms
Not Available
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Pharmacology

Indication

Investigated for use/treatment in diabetes mellitus type 2.

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Pharmacodynamics

Not Available

Mechanism of action

Insulin is released from the pancreas as hexamers. ISF402, a naturally occurring peptide tetramer, helps dispersal of insulin by allowing the insulin molecules to break free. As single molecules, the insulin is immediately available to bind to receptors on the liver, signalling the liver to take up and store sugar molecules from the blood. ISF402 also amplifies the signal generated by the receptors so that less insulin is needed for the liver's response. [Dia B Tech Website]

TargetActionsOrganism
UInsulinNot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
484649-95-8
InChI Key
BYWLSTFTCYEFLE-GIEZYDSUSA-N
InChI
InChI=1S/C19H31N7O7/c1-8(2)14(21)17(30)24-11(4-10-6-22-7-23-10)16(29)26-15(9(3)27)18(31)25-12(19(32)33)5-13(20)28/h6-9,11-12,14-15,27H,4-5,21H2,1-3H3,(H2,20,28)(H,22,23)(H,24,30)(H,25,31)(H,26,29)(H,32,33)/t9-,11+,12+,14+,15+/m1/s1
IUPAC Name
SMILES
[H][C@](C)(O)[C@]([H])(\N=C(/O)[C@]([H])(CC1=CN=CN1)\N=C(/O)[C@@]([H])(N)C(C)C)C(\O)=N\[C@@]([H])(CC(O)=N)C(O)=O

References

General References
  1. Paule SG, Nikolovski B, Ludeman J, Gray RE, Spiccia L, Zimmet PZ, Myers MA: Ability of GHTD-amide and analogs to enhance insulin activity through zinc chelation and dispersal of insulin oligomers. Peptides. 2009 Jun;30(6):1088-97. doi: 10.1016/j.peptides.2009.02.020. Epub 2009 Mar 20. [Article]
ChemSpider
88297866

Clinical Trials

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Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Targets

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Details1. Insulin
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
Specific Function
hormone activity
Gene Name
INS
Uniprot ID
P01308
Uniprot Name
Insulin
Molecular Weight
11980.795 Da

Drug created at March 19, 2008 16:24 / Updated at August 10, 2024 03:44