Resiniferatoxin

DB06515InvestigationalSmall molecule

Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain).

Mechanism: Pharmacologically active on Transient receptor potential cation channel subfamily V member 1
Curator reviewed
Primary indication: Investigated for use/treatment in interstitial cystitis and urinary incontinence.Curator reviewed
Formula / weight: C₃₇H₄₀O₉ · 628.718 g/mol (avg)

Resolves to

Compound

UNIIA5O6P1UL4ICAS57444-62-9ChEMBLCHEMBL17976PubChem104826

Structure

InChIKeyDSDNAKHZNJAGHN-MXTYGGKSSA-NSMILES

[H][C@]12O[C@]3(CC4=CC=CC=C4)O[C@]1(C[C@@]([H])(C)[C@]1(O3)[C@]3([H])C=C(C)C(=O)[C@@]3(O)CC(COC(=O)CC3=CC(OC)=C(O)C=C3)=C[C@@]21[H])C(C)=C

Targets

Q8NER1TRPV1

What you can answer from here — as of August 26, 2024

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

9Clinical trialsPhase, status and sponsor resolved per trial

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Resiniferatoxin, and which of those have an active Phase 3 trial?

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