1,2-Dihydroxynaphthalene
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Identification
- Generic Name
- 1,2-Dihydroxynaphthalene
- DrugBank Accession Number
- DB07610
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 160.1693
Monoisotopic: 160.0524295 - Chemical Formula
- C10H8O2
- Synonyms
- 1,2-Naphthalenediol
- 1,2-naphthohydroquinone
- beta-Naphthohydroquinone
- Naphthalene-1,2-diol
- β-naphthohydroquinone
- External IDs
- NSC-401609
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism U1,2-dihydroxynaphthalene dioxygenase Not Available Pseudomonas sp. (strain C18) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as naphthols and derivatives. These are naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Naphthalenes
- Sub Class
- Naphthols and derivatives
- Direct Parent
- Naphthols and derivatives
- Alternative Parents
- 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids / Organooxygen compounds / Hydrocarbon derivatives
- Substituents
- 1-hydroxy-2-unsubstituted benzenoid / 1-hydroxy-4-unsubstituted benzenoid / 1-naphthol / 2-naphthol / Aromatic homopolycyclic compound / Hydrocarbon derivative / Organic oxygen compound / Organooxygen compound
- Molecular Framework
- Aromatic homopolycyclic compounds
- External Descriptors
- naphthalenediol (CHEBI:17435) / a small molecule (NAPHTHALENE-12-DIOL)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2R5017T335
- CAS number
- 574-00-5
- InChI Key
- NXPPAOGUKPJVDI-UHFFFAOYSA-N
- InChI
- InChI=1S/C10H8O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6,11-12H
- IUPAC Name
- naphthalene-1,2-diol
- SMILES
- OC1=C(O)C2=CC=CC=C2C=C1
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0060497
- KEGG Compound
- C03012
- PubChem Compound
- 11318
- PubChem Substance
- 99444081
- ChemSpider
- 10842
- BindingDB
- 50049067
- ChEBI
- 17435
- ChEMBL
- CHEMBL204543
- ZINC
- ZINC000000407059
- PDBe Ligand
- D1N
- PDB Entries
- 2ei1
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.71 mg/mL ALOGPS logP 2.06 ALOGPS logP 2.36 Chemaxon logS -2.4 ALOGPS pKa (Strongest Acidic) 9.04 Chemaxon pKa (Strongest Basic) -6.3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 40.46 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 46.47 m3·mol-1 Chemaxon Polarizability 16.4 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9922 Blood Brain Barrier + 0.5569 Caco-2 permeable + 0.7786 P-glycoprotein substrate Non-substrate 0.5982 P-glycoprotein inhibitor I Non-inhibitor 0.9279 P-glycoprotein inhibitor II Non-inhibitor 0.9747 Renal organic cation transporter Non-inhibitor 0.8902 CYP450 2C9 substrate Non-substrate 0.8003 CYP450 2D6 substrate Non-substrate 0.8698 CYP450 3A4 substrate Non-substrate 0.65 CYP450 1A2 substrate Inhibitor 0.8783 CYP450 2C9 inhibitor Inhibitor 0.638 CYP450 2D6 inhibitor Non-inhibitor 0.8864 CYP450 2C19 inhibitor Non-inhibitor 0.6121 CYP450 3A4 inhibitor Non-inhibitor 0.9433 CYP450 inhibitory promiscuity High CYP Inhibitory Promiscuity 0.5079 Ames test AMES toxic 0.907 Carcinogenicity Non-carcinogens 0.9086 Biodegradation Not ready biodegradable 0.8429 Rat acute toxicity 2.2883 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9263 hERG inhibition (predictor II) Non-inhibitor 0.6828
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-01q9-0900000000-0f956a12d0643c144a3c Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-03di-0900000000-03099c7baff7081aacc4 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-03di-0900000000-88e1225d3a9e4a06d89d Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-0900000000-c8c463c1e5f65d1f2919 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0ufr-6900000000-a2e5a4faf61a14feb533 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-0900000000-f222d28e2f14cac63a03 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-0ugi-3900000000-c890480f5123d46d7db8 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 133.5184234 predictedDarkChem Lite v0.1.0 [M-H]- 133.6289234 predictedDarkChem Lite v0.1.0 [M-H]- 133.4623234 predictedDarkChem Lite v0.1.0 [M-H]- 128.14412 predictedDeepCCS 1.0 (2019) [M+H]+ 134.1817234 predictedDarkChem Lite v0.1.0 [M+H]+ 134.2494234 predictedDarkChem Lite v0.1.0 [M+H]+ 133.8904234 predictedDarkChem Lite v0.1.0 [M+H]+ 130.69713 predictedDeepCCS 1.0 (2019) [M+Na]+ 133.7738234 predictedDarkChem Lite v0.1.0 [M+Na]+ 133.7799234 predictedDarkChem Lite v0.1.0 [M+Na]+ 133.7851234 predictedDarkChem Lite v0.1.0 [M+Na]+ 139.33961 predictedDeepCCS 1.0 (2019)
Targets
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1. Details1,2-dihydroxynaphthalene dioxygenase
- Kind
- Protein
- Organism
- Pseudomonas sp. (strain C18)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- Specific Function
- Involved in the naphthalene catabolic pathway. Catalyzes the meta-cleavage of 1,2-dihydroxynaphthalene (1,2-DHN) to yield 2-hydroxychromene-2-carboxylic acid (By similarity).
- Gene Name
- doxG
- Uniprot ID
- P0A108
- Uniprot Name
- 1,2-dihydroxynaphthalene dioxygenase
- Molecular Weight
- 33941.375 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Drug created at September 15, 2010 21:24 / Updated at June 12, 2020 16:52