Trefentanil

DB09181ExperimentalSmall molecule

Trefentanil (A-3665) is a fentanyl analogue opioid developed in 1992. It is more potent and shorter acting than alfentanil. Trefentanil is not used in clinics due to the severity of... Trefentanil is not used in clinics due to the severity of its respiratory depression, though it is still used in research.

Chemical structure of Trefentanil
Formula / weight
C25H31FN6O2 · 466.561 g/mol (avg)
Code names
A-2665 · A-3665

Resolves to

Compound
UNII36QM58LVGUCAS120656-74-8ChEMBLCHEMBL84617PubChem60728
Structure
InChIKeyRJSCINHYBGMIFT-UHFFFAOYSA-NSMILESCCN1N=NN(CCN2CCC(CC2)(N(C(=O)CC)C2=CC=CC=C2F)C2=CC=CC=C2)C1=O
Targets
P35372OPRM1

What you can answer from here — as of September 16, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with Trefentanil, and which of those have an active Phase 3 trial?

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