Choline C 11 is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis of phospholipids which are essential components of all cell membranes. It... It was developed by MCPRF and FDA first approved in September 2012.
- Mechanism
- Curator reviewed · 2 references
Choline is incorporated into phosphatidylcholine which is a major membrane phospholipid in mammalian cells. The use of choline C11 is based on the knowledge that malignant tumors with increased cellular proliferation take up more choline when compared with normal cells for the formation of cellular membranes. The increased uptake of choline is explained by its use as a substrate in phospholipid synthesis in cell membranes, transmembrane signaling, and lipid and cholesterol transport and metabolism.
- Primary indication
- Choline C11 is indicated for its use in positron emission tomography (PET) imaging in patients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography or magnetic resonance imaging.Curator reviewed
- Formula / weight
- C5H14ClNO · 138.62 g/mol (avg)
- Also known as
- 11C-choline · 11C-choline chloride
Resolves to
SGMZJAMFUVOLNK-ULWFUOSBSA-MSMILES[Cl-].C[N+](C)([11CH3])CCOWhat you can answer from here — as of September 15, 2026
Which drugs share a target with Choline C 11, and which of those have an active Phase 3 trial?
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