Indium In-111 chloride

Identification

Summary

Indium In-111 chloride is a diagnostic radiopharmaceutical agent used for radiolabelling monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures.

Brand Names
Indiclor, Octreoscan
Generic Name
Indium In-111 chloride
DrugBank Accession Number
DB09490
Background

Indium In-111 Chloride is a diagnostic radiopharmaceutical agent intended for radiolabeling OncoScint (satumomab pendetide) or ProstaScint (capromab pendetide) used for in vivo diagnostic imaging procedures and for radiolabeling Zevalin (ibritumomab tiuxetan) in preparations used for radioimmunotherapy procedures. It is supplied as a sterile, pyrogen-free solution of Indium ("'In) Chloride in O.04M HCI.

Type
Small Molecule
Groups
Approved
Structure
Weight
Average: 217.26
Monoisotopic: 215.8116688
Chemical Formula
Cl3In
Synonyms
  • 111indium trichloride
  • Indium (111In) chloride
  • Indium chloride (111InCl3)
  • Indium chloride In-111
  • Indium In 111 chloride
  • Indium In 111m chloride
  • Indium In-111m chloride
  • Indium-111 chloride

Pharmacology

Indication

Indium In-111 Chloride is indicated for radio labeling of monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures. Indiclor is also indicated for radiolabeling Zevalin in preparations used for radio immunotherapy procedure

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination for diagnostic processGastrointestinal tumorsCombination Product in combination with: Indium In-111 pentetreotide (DB11835)•••••••••••••••••••••• ••••••• ••• ••••••••
Used in combination for diagnostic processPancreatic tumoursCombination Product in combination with: Indium In-111 pentetreotide (DB11835)•••••••••••••••••••••• ••••••• ••• ••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its pharmacodynamics is related to the final product and not specific to Indium In-111 Chloride alone

Mechanism of action

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its mechanism of action is related to the final product and not specific to Indium In-111 Chloride alone

Absorption

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its absoption is related to the final product and not specific to Indium In-111 Chloride alone

Volume of distribution

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its volume of distribution is related to the final product and not specific to Indium In-111 Chloride alone

Protein binding

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its protein binding is related to the final product and not specific to Indium In-111 Chloride alone

Metabolism

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its metabolism is related to the final product and not specific to Indium In-111 Chloride alone

Route of elimination

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Itsroute of elimination is related to the final product and not specific to Indium In-111 Chloride alone

Half-life

2.8 days

Clearance

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its clearance is related to the final product and not specific to Indium In-111 Chloride alone

Adverse Effects
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Toxicity

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its toxicity is related to the final product and not specific to Indium In-111 Chloride alone

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
  • Drink plenty of fluids. Fluids will help remove excess radiation from the body when Indium In-111 chloride is used to radiolabel pentetreotide.

Products

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Active Moieties
NameKindUNIICASInChI Key
Indium cation In-111ionicWJZ06C0H8L131391-70-3RJMMFJHMVBOLGY-AHCXROLUSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
IndiclorSolution5 mCi/0.5mLIntravenousMedi-Physics Inc.1992-12-292019-06-06US flag
Indium In 111 ChlorideSolution10 mCi/1mLIntravenousCurium US LLC2007-12-07Not applicableUS flag
Indium In 111 ChlorideSolution10 mCi/1mLIntravenousMallinckrodt2007-12-072017-07-01US flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
INDIO (111-IN) OSSINA CURIUM NETHERLANDSIndium In-111 chloride (37 MBQ/ML) + Oxyquinoline (0.025 mg/ml)Injection, solutionIntravenousCurium Netherlands B.V.2020-11-18Not applicableItaly flag
OCTREOSCANIndium In-111 chloride (111 MBq/ml) + Indium In-111 pentetreotide (10 mcg)Injection, powder, for solutionIntravenousCurium Netherlands B.V.2014-07-08Not applicableItaly flag
OctreoscanIndium In-111 chloride (3 mCi/1mL) + Indium In-111 pentetreotide (10 ug/1mL)KitIntravenousCurium US LLC2015-10-14Not applicableUS flag
OctreoscanIndium In-111 chloride (3 mCi/1mL) + Indium In-111 pentetreotide (10 ug/1mL)KitIntravenousMallinckrodt2007-05-012017-07-01US flag
OctreoScan - Pulver zur Herstellung einer InjektionslösungIndium In-111 chloride (111 MBq/ml) + Pentetreotide (10 mcg)Injection, powder, for solutionIntravenousCurium Netherlands B.V.1999-07-15Not applicableAustria flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as post-transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal salts
Sub Class
Post-transition metal chlorides
Direct Parent
Post-transition metal chlorides
Alternative Parents
Inorganic chloride salts
Substituents
Inorganic chloride salt / Inorganic salt / Post-transition metal chloride
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
58TD96H03I
CAS number
50800-85-6
InChI Key
PSCMQHVBLHHWTO-FZTWWWDYSA-K
InChI
InChI=1S/3ClH.In/h3*1H;/q;;;+3/p-3/i;;;1-4
IUPAC Name
trichloro(¹¹¹In)indigane
SMILES
Cl[111In](Cl)Cl

References

General References
  1. FDA label [Link]
PubChem Compound
49800058
PubChem Substance
347827862
ChemSpider
4954694
RxNav
42987

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4TerminatedDiagnosticSolid Tumors1
1, 2TerminatedDiagnosticGastroenteropancreatic Neuroendocrine Tumors1
Not AvailableCompletedDiagnosticSarcoidosis1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntravenous5 mCi/0.5mL
SolutionIntravenous
Injection, solutionIntravenous
Injection, solutionIntrathecal
InjectionIntravenous370 MBq/ml
SolutionIntravenous10 mCi/1mL
KitIntravenous
Injection, powder, for solutionIntravenous
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US6123916No2000-09-262017-09-26US flag
US5776894No1998-07-072015-07-07US flag

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility27.4 mg/mLALOGPS
logP1.69ALOGPS
logP1.9Chemaxon
logS-0.91ALOGPS
Physiological Charge0Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity18.41 m3·mol-1Chemaxon
Polarizability9.87 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at November 30, 2015 19:10 / Updated at February 13, 2021 10:51