Indium In-111 chloride
Identification
- Name
- Indium In-111 chloride
- Accession Number
- DB09490
- Description
Indium In-111 Chloride is a diagnostic radiopharmaceutical agent intended for radiolabeling OncoScint (satumomab pendetide) or ProstaScint (capromab pendetide) used for in vivo diagnostic imaging procedures and for radiolabeling Zevalin (ibritumomab tiuxetan) in preparations used for radioimmunotherapy procedures. It is supplied as a sterile, pyrogen-free solution of Indium ("'In) Chloride in O.04M HCI.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Indium In-111 chloride (DB09490)
- Weight
- Average: 217.26
Monoisotopic: 215.8116688 - Chemical Formula
- Cl3In
- Synonyms
- 111indium trichloride
- Indium (111In) chloride
- Indium chloride (111InCl3)
- Indium chloride In-111
- Indium In 111 chloride
- Indium In 111m chloride
- Indium In-111m chloride
- Indium-111 chloride
Pharmacology
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Indium In-111 Chloride is indicated for radio labeling of monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures. Indiclor is also indicated for radiolabeling Zevalin in preparations used for radio immunotherapy procedure
- Associated Conditions
- Contraindications & Blackbox Warnings
Contraindications & Blackbox WarningsWith our commercial data, access important information on dangerous risks, contraindications, and adverse effects.Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects- Pharmacodynamics
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its pharmacodynamics is related to the final product and not specific to Indium In-111 Chloride alone
- Mechanism of action
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its mechanism of action is related to the final product and not specific to Indium In-111 Chloride alone
- Absorption
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its absoption is related to the final product and not specific to Indium In-111 Chloride alone
- Volume of distribution
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its volume of distribution is related to the final product and not specific to Indium In-111 Chloride alone
- Protein binding
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its protein binding is related to the final product and not specific to Indium In-111 Chloride alone
- Metabolism
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its metabolism is related to the final product and not specific to Indium In-111 Chloride alone
- Route of elimination
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Itsroute of elimination is related to the final product and not specific to Indium In-111 Chloride alone
- Half-life
2.8 days
- Clearance
Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its clearance is related to the final product and not specific to Indium In-111 Chloride alone
- Adverse Effects
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Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its toxicity is related to the final product and not specific to Indium In-111 Chloride alone
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Drink plenty of fluids. Fluids will help remove excess radiation from the body when Indium In-111 chloride is used to radiolabel pentetreotide.
Products
Comprehensive & structured drug product infoFrom application numbers to product codes, connect different identifiers through our commercial datasets.Easily connect various identifiers back to our datasets- Active Moieties
Name Kind UNII CAS InChI Key Indium cation In-111 ionic WJZ06C0H8L 131391-70-3 RJMMFJHMVBOLGY-AHCXROLUSA-N - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Indiclor Solution 5 mCi/0.5mL Intravenous Medi-Physics Inc. 1992-12-29 2019-06-06 US 
Indium In 111 Chloride Solution 10 mCi/1mL Intravenous Curium US LLC 2007-12-07 Not applicable US Indium In 111 Chloride Solution 10 mCi/1mL Intravenous Mallinckrodt 2007-12-07 2017-07-01 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Octreoscan Indium In-111 chloride (3 mCi/1mL) + Indium In-111 pentetreotide (10 ug/1mL) Kit Intravenous Curium US LLC 2015-10-14 Not applicable US Octreoscan Indium In-111 chloride (3 mCi/1mL) + Indium In-111 pentetreotide (10 ug/1mL) Kit Intravenous Mallinckrodt 2007-05-01 2017-07-01 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as post-transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a post-transition metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Post-transition metal salts
- Sub Class
- Post-transition metal chlorides
- Direct Parent
- Post-transition metal chlorides
- Alternative Parents
- Inorganic chloride salts
- Substituents
- Inorganic chloride salt / Inorganic salt / Post-transition metal chloride
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
Chemical Identifiers
- UNII
- 58TD96H03I
- CAS number
- 50800-85-6
- InChI Key
- PSCMQHVBLHHWTO-FZTWWWDYSA-K
- InChI
- InChI=1S/3ClH.In/h3*1H;/q;;;+3/p-3/i;;;1-4
- IUPAC Name
- trichloro(¹¹¹In)indigane
- SMILES
- Cl[111In](Cl)Cl
References
- General References
- FDA label [Link]
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Terminated Diagnostic Tumors, Solid 1 1, 2 Terminated Diagnostic Gastroenteropancreatic Neuroendocrine Tumors 1 Not Available Completed Diagnostic Sarcoidosis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intravenous 5 mCi/0.5mL Solution Intravenous 370 MBQ/ML Injection, solution Intravenous 37 MBQ/ML Injection, solution Intrathecal 37 MBQ/ML Solution Intravenous 10 mCi/1mL Kit Intravenous Injection, powder, for solution Intravenous 111 MBq/ml - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US6123916 No 2000-09-26 2017-09-26 US US5776894 No 1998-07-07 2015-07-07 US
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 27.4 mg/mL ALOGPS logP 1.69 ALOGPS logP 1.9 ChemAxon logS -0.91 ALOGPS Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 0 ChemAxon Hydrogen Donor Count 0 ChemAxon Polar Surface Area 0 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 18.41 m3·mol-1 ChemAxon Polarizability 9.87 Å3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created on November 30, 2015 19:10 / Updated on February 13, 2021 10:51