Pyrimidines
- Name
- Pyrimidines
- Accession Number
- DBCAT000349
- Description
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
- Drugs
Drug Drug Description 1-Methylcytosine Not Available 2'-C-methylcytidine A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks... 2'-cytidylic acid Not Available 2'-Deoxy-thymidine-beta-L-rhamnose Not Available 2'-Deoxycytidine 5'-triphosphate Not Available 2'-Deoxyuridine 2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. [PubChem] 2'-fluoro-5-ethylarabinosyluracil 2'-fluoro-5-ethylarabinosyluracil (FAU) has been used in trials studying the treatment of Small Intestine Lymphoma, Stage IV Mantle Cell Lymphoma, Waldenström Macroglobulinemia, Splenic Marginal Zone Lymphoma, and Recurrent Mantle Cell Lymphoma,... 3-Deazacytidine Not Available 3-Methylcytosine Not Available 3'-Uridinemonophosphate Not Available 5-Aminouracil Not Available 5-Benzylacyclouridine Not Available 5-fluoro-2'-deoxycytidine 5-fluoro-2'-deoxycytidine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, and Urinary Bladder Neoplasms, among others. 5-fluoro-2'-deoxyuridine-5'-monophosphate Not Available 5-fluorouridine 5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compounds comprising a pyrimidine... 5-Iodouracil Not Available 5-methylcytidine 5'-monophosphate Not Available 5-Methyluridine triphosphate Not Available 5,6-Diaminouracil Not Available 5,6-dihydro-5-azacytidine Not Annotated 6-aza uridine 5'-monophosphate Not Available ABT-072 ABT-072 is under investigation in clinical trial NCT00890318 (A Study in Healthy Adult Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetic Profiles of Multiple Doses of ABT-072 Used to Treat... Adafosbuvir Adafosbuvir is under investigation in clinical trial NCT02894905 (A Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of AL-335). Adavosertib MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others. Aditoprim Aditoprim is a small molecule drug. Aditoprim has a monoisotopic molecular weight of 303.17 Da. Allobarbital Not Annotated Alogliptin A dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat hyperglycemia in patients with type 2 diabetes mellitus. Amobarbital A barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures. Ancitabine Ancitabine is a small molecule drug. The usage of the INN stem '-citabine' in the name indicates that Ancitabine is a nucleoside antiviral or antineoplastic agent, cytarabine or azacitidine derivative.... Apricitabine Apricitabine has been used in trials studying the treatment of HIV Infections. Aprobarbital Aprobarbital is a barbiturate derivative synthesized in the 1920s by Ernst Preiswerk. It was determined that the substance was capable of demonstrating sedative, hypnotic, and anticonvulsant effects. A primary treatment... Azacitidine A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. Azaribine Not Annotated AZD-4877 AZD4877 has been used in trials studying the treatment of NHL, Tumors, Cancer, Lymphoma, and Neoplasms, among others. AZD-6482 AZD-6482 is under investigation in clinical trial NCT00688714 (Study to Investigate Safety and Tolerability of a Single Dose of AZD6482). Azvudine Azvudine is under investigation in clinical trial NCT04668235 (Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (Sars-cov-2 Infected)). Barbexaclone Created for the treatment for epilepsy, with the intent of creating an antiepileptic with less sedative properties than phenobarbital. Barbital A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice... Benfotiamine A derivative of thiamine thought to be useful in the management of diabetic neuropathy, although evidence is lacking. Bentiamine Bentiamine is a small molecule drug. Bentiamine has a monoisotopic molecular weight of 490.17 Da. Benzoyloxymethylthiamine Not Annotated Benzylthiouracil Not Annotated Bosentan A dual endothelin receptor antagonist used to treat pulmonary arterial hypertension. Brallobarbital Brallobarbital is a small molecule drug. Brallobarbital has a monoisotopic molecular weight of 286.0 Da. Brincidofovir An oral lipid prodrug of cidofovir used in the treatment of human smallpox disease. Brivudine A drug used to treat herpes zoster. Brodimoprim Not Annotated Bropirimine Not Available Broxuridine Broxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer. Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Butabarbital A barbiturate drug used as a sedative and hypnotic. Butalbital A barbiturate drug used for symptomatic treatment of tension-type headache in various combinations with acetaminophen, aspirin, caffeine, and codeine. Butobarbital For the treatment of insomnia. Cambinol An investigational histone deacetylase inhibitor that may have future use in cancer treatment. Capivasertib A serine/threonine kinase inhibitor used to treat hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer Carmofur Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy. CE-224535 CE-224535 has been used in trials studying the treatment of Osteoarthritis. Cedazuridine A cytidine deaminase inhibitor coadministered with the hypomethylating agent decitabine for the treatment of variable forms of myelodysplastic syndrome (MDS). Censavudine Censavudine has been used in trials studying the treatment of HIV-1 Infection. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Cidofovir An antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS. Citicoline An endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. Clevudine Investigated for use/treatment in hepatitis (viral, B). Cocarboxylase The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Cyclic 3',5'-thymidine monophosphate Not Available Cyclobarbital Not Annotated Cyclouridine Not Available Cytarabine A pyrimidine nucleoside analogue used to treat acute non-lymphocytic leukemia, lymphocytic leukemia, and the blast phase of chronic myelocytic leukemia. Cytidine A drug used to manage neuropsychiatric deficits associated with cerebrovascular diseases in combination with uridine. Cytidine 3'-monophosphate Not Available Cytidine-5'-Monophosphate A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase. Daprodustat A small-molecule hypoxia-inducible factor prolyl hydroxylase inhibitor used for the treatment of anemia in patients with chronic kidney disease. Darapladib Investigated for use/treatment in atherosclerosis. Dasabuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Dasatinib A tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia or chronic myeloid leukemia. Decitabine A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression. Denufosol For use as an inhaled treatment for cystic fibrosis. Deoxycytidylyl-3',5'-guanosine Not Available Deoxyuridine monophosphate Not Available Dexelvucitabine Dexelvucitabine has been used in trials studying the treatment of HIV Infections and Human Immunodeficiency Virus. Dihydrouracil Not Available Dihydrouridine Not Annotated Dipyridamole A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events. Diquafosol A medication indicated to treat dry eyes associated with keratoconjunctival disorders. Donetidine Donetidine is a small molecule drug. The usage of the INN stem '-tidine' in the name indicates that Donetidine is a histamine- H2-receptor antagonist, cimetidine derivative. Donetidine has a monoisotopic... Doxecitine A pyrimidine nucleoside used to treat thymidine kinase 2 deficiency. Doxifluridine Doxifluridine has been investigated for the treatment of Stomach Cancer. Edoxudine A deoxythymidine analog used to treat herpetic keratitis. Elacytarabine Investigated for use/treatment in leukemia (unspecified) and melanoma. Elvucitabine Investigated for use/treatment in hepatitis (viral, B) and HIV infection. Emitefur Emitefur is a small molecule drug. Emitefur has a monoisotopic molecular weight of 558.12 Da. Emivirine Emivirine has been used in trials studying the treatment of HIV Infections. Emtricitabine A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV. Enibomal Not Annotated Eniluracil For the treatment of cancer in combination with 5-fluorouracil. Ensifentrine A phosphodiesterase inhibitor used for the maintenance treatment of chronic obstructive pulmonary disease (COPD) in adults. Epirizole Epirizole is an oral nonsteroidal anti-inflammatory drug (NSAID) used for muscle and joint pain. Epiroprim Epiroprim is a small molecule drug. Epiroprim has a monoisotopic molecular weight of 353.19 Da. Eterobarb Eterobarb is a small molecule drug. Eterobarb has a monoisotopic molecular weight of 320.14 Da. Febarbamate Not Annotated Fiacitabine Fiacitabine has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections. Fialuridine Fialuridine is under investigation in clinical trial NCT01337466 (Biodistribution and Dosimetry Evaluation of [124I]FIAU). Fiduxosin Fiduxosin is a small molecule drug. Fiduxosin has a monoisotopic molecular weight of 555.19 Da. Firsocostat Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)). Floxuridine An antimetabolite used as palliative management for liver metastases of gastrointestinal malignancy. Flucytosine An antifungal indicated only to treat severe infections throughout the body caused by susceptible strains of Candida or Cryptococcus. Fluorocyclopentenylcytosine Fluorocyclopentenylcytosine is under investigation in clinical trial NCT03189914 (RX-3117 in Combination With Abraxane® in Subjects With Metastatic Pancreatic Cancer). Fluorouracil A pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment. Formycin Not Available Formycin B Not Available Forodesine Investigated for use/treatment in lymphoma (non-hodgkin's) and leukemia (lymphoid). Foscenvivint PRI-724 is under investigation in clinical trial NCT03620474 (Safety and Effectiveness of PRI-724 for Hepatitis C or B Virus Derived Liver Cirrhosis). Fosgemcitabine palabenamide NUC-1031 is under investigation in clinical trial NCT03610100 (Acelarin First Line Randomised Pancreatic Study). Fozivudine Tidoxil Fozivudine Tidoxil has been used in trials studying the treatment of HIV Infections. Freselestat Investigated for use/treatment in chronic obstructive pulmonary disease (COPD). Fursultiamine Compound used for therapy of thiamine deficiency. It has also been suggested for several non-deficiency disorders but has not yet proven useful. Fursultiamine is a vitamin B1 derivative. Galactose-uridine-5'-diphosphate A nucleoside diphosphate sugar which can be epimerized into UDPglucose for entry into the mainstream of carbohydrate metabolism. Serves as a source of galactose in the synthesis of lipopolysaccharides, cerebrosides,... Galocitabine Galocitabine is a small molecule drug. The usage of the INN stem '-citabine' in the name indicates that Galocitabine is a nucleoside antiviral or antineoplastic agent, cytarabine or azacitidine derivative.... Gemcitabine A nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer. Gemcitabine elaidate Gemcitabine elaidate has been used in trials studying the treatment of Solid Tumor, Lung Cancer, Non-small-cell Lung Cancer, and Metastatic Pancreatic Adenocarcinoma. Gisadenafil Gisadenafil has been investigated for the treatment of Prostatic Hyperplasia. Guadecitabine Guadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer. Heptabarbital Used mainly for sedation and hypnosis. Hexetidine An topical antiseptic agent used for disinfection and prevention of bacterial, fungal and yeast infections of the oral and vaginal mucosa. Hexobarbital For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful... Ibacitabine Not Annotated ICG-001 Not Annotated Idoxuridine A pyrimidine analog antiviral used for the treatment of viral eye infections, including herpes simplex keratitis. Imatinib A tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors. Immucillin-G Not Available Iodothiouracil Iodothiouracil is a small molecule drug. The usage of the INN stem '-racil' in the name indicates that Iodothiouracil is a uracil type antineoplastic. Iodothiouracil has a monoisotopic molecular weight... IQP-0528 IQP-0528 is under investigation in clinical trial NCT03082690 (ImQuest (IQP) DuoGel Phase 1 Pharmacokinetic Study). Lamivudine A reverse transcriptase inhibitor used to treat HIV and hepatitis B infections. Letaxaban Letaxaban has been used in trials studying the treatment and prevention of Venous Thromboembolism and Acute Coronary Syndrome. Lumicitabine Lumicitabine is under investigation in clinical trial NCT03010059 (A Study to Assess the Relative Bioavailability of JNJ64041575 Administered as 2 Different New Concept Formulations (Oral Suspension and Tablet) Compared to... Lupitidine Lupitidine is a small molecule drug. The usage of the INN stem '-tidine' in the name indicates that Lupitidine is a histamine- H2-receptor antagonist, cimetidine derivative. Lupitidine has a monoisotopic... LY-2334737 LY2334737 has been used in trials studying the treatment of Solid Tumor, Metastatic Tumor, and Malignant Solid Tumor. Magnesium orotate Magnesium orotate is a magnesium salt of orotic acid and is poorly soluble in water. It is a source of magnesium and is used as a mineral supplement to treat... Mavacamten A myosin inhibitor used to treat obstructive hypertrophic cardiomyopathy. MB07133 Not Annotated Mericitabine Mericitabine has been investigated for the treatment of Hepatitis C, Chronic. Mericitabine is a polymerase inhibitor being developed for the treatment of chronic hepatitis C. Mericitabine is a prodrug of... Metharbital Metharbital is used for the treatment of epilepsy. Methohexital An anesthetic used to induce deep sedation. Methylphenobarbital For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. Methylthiouracil Not Annotated Metioprim Metioprim is a small molecule drug. Metioprim has a monoisotopic molecular weight of 306.12 Da. Metoprine Not Available Minoxidil An antihypertensive vasodilating agent used for resistant hypertension that is symptomatic or has caused end organ damage. Miricorilant Miricorilant is under investigation in clinical trial NCT03818256 (Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant (CORT118335) in Obese Adult Patients With Schizophrenia and Recent Weight Gain While Taking... Mirodenafil Mirodenafil has been used in trials studying the treatment and supportive care of Kidney Diseases, Urologic Diseases, Renal Insufficiency, Erectile Dysfunction, and Male Erectile Dysfunction. Molnupiravir An orally bioavailable isopropylester cytidine analog used to treat COVID-19. Monophosphothiamine A B vitamin for supplementation to treat macrocytic anemia, and other conditions caused by B vitamin deficiencies. N4-Hydroxycytidine A cytidine analog being investigated to treat COVID-19. Navuridine Not Annotated Netivudine Netivudine has been used in trials studying the treatment of Chickenpox and HIV Infections. Nicarbazin Not Annotated Nifekalant Nifekalant is under investigation in clinical trial NCT03855826 (Evaluation of the Efficacy and Safety of Nifekalant Hydrochloride (NIF) Injection). North-methanocarbathymidine Not Annotated Ocaperidone Investigated for use/treatment in schizophrenia and schizoaffective disorders. Orotic acid A drug used to manage uncomplicated liver dysfunction in combination with xanthine. Orotidylic acid Not Available Oxantel An antihelminthic indicated in the treatment of ascaris, trichocephaliasis, and oxyuriasis infections. Oxypurinol Intended for the treatment of congestive heart failure and hyperuricemia. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Pemirolast A medication used to treat allergies such as hay fever and allergic conjunctivitis. Pentobarbital A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. Pentostatin An adenosine deaminase inhibitor used to treat hairy cell leukemia. PF-04447943 PF-04447943 has been investigated for the treatment of Alzheimer's Disease. PF-06282999 Pf 06282999 is under investigation in clinical trial NCT01626976 (A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects). Phenobarbital A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. Phetharbital Phetharbital is a small molecule drug. Phetharbital has a monoisotopic molecular weight of 260.12 Da. Primidone An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. Propylthiouracil A thiourea antithyroid agent used to treat hyperthyroidism. Proxibarbal Proxibarbal is a derivative of barbiturates, which has been used to treat migraines. Proxibarbal was approved in France but was withdrawn from the market due to the risk of inducing... Pyrantel An anthelmintic used to treat helminth infections. Pyrimethamine An antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria. Racivir Racivir, also known as RCV, is an oxothiolane nucleoside reverse transcriptase inhibitor similar to emtricitabine and lamivudine. Racivir is a 50:50 mixture of emtricitabine and its positive enantiomer. Racivir has... Radgocitabine 2'-cyano-2'-deoxy-1-(beta-D-arabinofuranosyl)cytosine has been used in trials studying the treatment of Advanced Colorectal Cancer. Relugolix An oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer. Resmetirom A thyroid hormone receptor-beta agonist used to treat noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis in adults. Revaprazan Revaprazan is under investigation in clinical trial NCT01750437 (Phase 2 Clinical Trial to Investigate the Safety, Tolerability and Efficacy of YH1885L in Patients With Non-erosive Reflux Disease(nerd)). Rilpivirine A non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to specifically treat human immunodeficiency virus type 1 (HIV-1). Rimazolium Rimazolium is an experimental analgesic drug . Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Ritanserin Ritanserin has been used in trials studying the treatment of Cocaine-Related Disorders. Ropidoxuridine Investigated for use/treatment in cancer/tumors (unspecified). Rosuvastatin An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. Sapacitabine Investigated for use/treatment in solid tumors, cutaneous t-cell lymphoma, myelodysplastic syndrome, and leukemia (lymphoid). SAR-260301 Not Annotated Secobarbital A barbiturate used for the short-term treatment of insomnia. Setoperone Setoperone is a small molecule drug. The usage of the INN stem '-perone' in the name indicates that Setoperone is a tranquillizer, neuroleptic, 4'-fluoro-4-piperidinobutyrophenone derivative. Setoperone has a monoisotopic molecular... Sofosbuvir A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents. Sorivudine Sorivudine has been used in trials studying the treatment of Chickenpox and HIV Infections. Sparsomycin An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems. [PubChem] Stavudine A dideoxynucleoside used in the treatment of HIV infection. Stavudine triphosphate Not Available Sulbutiamine A thiamine derivative indicated in the treatment of asthenia. TAK-733 TAK-733 has been used in trials studying the treatment of Advanced Metastatic Melanoma, Advanced Nonhematologic Malignancies, and Advanced Non-hematologic Malignancies. Talbutal For use as a sedative and hypnotic. TAS-102 TAS-102 (Taiho Pharma USA, Inc.) is an anti-cancer drug under development and in stage 3 clinical trials for the treatment of colorectal cancer. It is composed of the thymidine phosphorylase... TAS-106 Investigated for use/treatment in solid tumors and cancer/tumors (unspecified). Tegafur An antineoplastic agent used in combination with other anticancer medications to treat advanced gastric and colorectal cancers. Telbivudine A thymidine nucleoside analog used for the treatment of chronic hepatitis B with clinical evidence of viral replication or persistent elevations in serum aminotransferases (ALT or AST). Temelastine Temelastine is a small molecule drug. The usage of the INN stem '-astine' in the name indicates that Temelastine is a antihistaminic. Temelastine has a monoisotopic molecular weight of 441.12... Tetrahydrouridine Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others. Tezacitabine Investigated for use/treatment in colorectal cancer, lung cancer, leukemia (unspecified), and gastric cancer. Thiamine A vitamin used to correct vitamin B1 deficiency. Thiamine disulfide A B-vitamin indicated to treat neurological conditions caused by B vitamin deficiency. Thiamylal Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. Thiopental A barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. Thymectacin Investigated for use/treatment in colorectal cancer. Thymidine A deoxynucleoside that is a fundamental building block of DNA used to treat thymidine deficiency. Thymidine 5'-triphosphate Not Available Thymidine monophosphate 5-Thymidylic acid. A thymine nucleotide containing one phosphate group esterified to the deoxyribose moiety. Thymine Not Available Tipiracil A thymidine phosphorylase inhibitor used as an adjunct treatment of adult patients with certain types of gastric or colorectal malignancies. Tolimidone Not Annotated Trametinib A kinase inhibitor used alone or in combination with dabrafenib to treat patients with cancers with specific BRAF mutations, such as melanoma and non-small cell lung cancer. Trapidil Used in the treatment of chronic stable angina . Trelagliptin A dipeptidyl peptidase-4 inhibitor indicated in the control of diabetes mellitus. Trifluridine A nucleoside metabolic inhibitor used to treat keratoconjunctivitis and epithelial keratitis caused by simplex virus, and as a part of chemotherapy for certain types of metastatic gastrointestinal cancers. Trimethoprim An antifolate antibiotic often used in combination with sulfamethoxazole to treat a number of infections, including those of the urinary tract, respiratory tract, and gastrointestinal tract. Troxacitabine Investigated for use/treatment in leukemia (myeloid). Tunicamycin Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. One member of this family is the enzyme GlcNAc phosphotransferase (GPT), which catalyzes... Tunodafil Tunodafil is a small molecule drug. The usage of the INN stem '-afil' in the name indicates that Tunodafil is a inhibitor of phosphodiesterase PDE5 with vasodilator action. Tunodafil is... UDP-alpha-D-glucuronic acid A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides.... Ulodesine Ulodesine has been used in trials studying the treatment of Gout, Arthritis, Hyperuricemia, and Joint Disease. Uprifosbuvir Uprifosbuvir is under investigation in clinical trial NCT02332707 (Efficacy and Safety of Grazoprevir (MK-5172) and Uprifosbuvir (MK-3682) With Elbasvir (MK-8742) or Ruzasvir (MK-8408) for Chronic Hepatitis C Genotype (GT)1 and... Uracil An antineoplastic agent used in combination with tegafur to treat various cancers, including breast, prostate, and liver cancer. Uracil mustard Used for its antineoplastic properties. Uridine A drug used to manage neuropsychiatric deficits associated with cerebrovascular diseases in combination with cytidine. Uridine 5'-triphosphate Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety. Uridine diphosphate glucose A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and... Uridine monophosphate 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position. Uridine triacetate A pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine. Valopicitabine The 3-O-valine ester prodrug of the nucleoside analog 2'-C-methylcytidine with anti-hepatitis C virus (HCV) activity. Upon administration, valopicitabine is converted into 2'-C-methylcytidine; upon phosphorylation into its 5-triphosphate form, this metabolite... Verdiperstat Verdiperstat has been used in trials studying the basic science and treatment of Multiple System Atrophy (MSA). Vibegron A beta-3 adrenergic agonist the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency in adults. Vinylbital Not Annotated Willardiine Willardiine is a compound isolated from seeds of Acacia willariana. Zalcitabine A dideoxynucleoside used to treat HIV. Zebularine A chemically stable, cytidine analog that displays anti-tumor properties. It acts as a transition state analog inhibitor of cytidine deaminase by binding to the active site as covalent hydrates. Also... Zidovudine A dideoxynucleoside used in the treatment of HIV infection. Zidovudine diphosphate Not Available Zidovudine monophosphate Not Available Zinc orotate A zinc supplement indicated in zinc deficiency. Zoliflodacin A spiropyrimidinetrione bacterial type II topoisomerase inhibitor indicated for the treatment of uncomplicated urogenital gonorrhea caused by Neisseria gonorrhoeae. - Drugs & Drug Targets