Protein Kinase Inhibitors

Name
Protein Kinase Inhibitors
Accession Number
DBCAT000737
Description

Agents that inhibit PROTEIN KINASES.

ATC Classification
Drugs
DrugDrug Description
GefitinibA tyrosine kinase inhibitor used as first-line therapy to treat non-small cell lung carcinoma (NSCLC) that meets certain genetic mutation criteria.
SorafenibA kinase inhibitor used in the treatment of unresectable liver carcinoma and advanced renal carcinoma.
ErlotinibAn EGFR tyrosine kinase inhibitor used to treat certain small cell lung cancers or advanced metastatic pancreatic cancers.
ImatinibA tyrosine kinase inhibitor used to treat a number of leukemias, myelodysplastic/myeloproliferative disease, systemic mastocytosis, hypereosinophilic syndrome, dermatofibrosarcoma protuberans, and gastrointestinal stromal tumors.
DasatinibA tyrosine kinase inhibitor used for the treatment of lymphoblastic or chronic myeloid leukemia with resistance or intolerance to prior therapy.
LapatinibAn antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-negative breast cancer in patients who received prior chemotherapeutic treatments.
TemsirolimusA antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR.
AxitinibAn oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.
CrizotinibA receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive.
PonatinibA kinase inhibitor used to treat patients with various types of chronic myeloid leukemia (CML).
TrametinibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
DabrafenibA kinase inhibitor used to treat patients with specific types of melanoma, non-small cell lung cancer, and thyroid cancer.
CeritinibAn antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib.
PalbociclibAn endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer.
LenvatinibA receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma.
MasitinibMasitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the...
CediranibFor the treatment of liver cancer, advanced non-small cell lung cancer (NSCLC), advanced colorectal cancer (CRC) and other solid tumors.
GenisteinCurrently Genistein is being studied in clinical trials as a treatment for prostate cancer.
7-HydroxystaurosporineNot Available
AlvocidibInvestigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified).
VatalanibUsed in combination with first- and second-line chemotherapy for the treatment of metastatic colorectal cancer and non-small cell lung cancer (NSCLC).
AT9283Investigated for use/treatment in cancer/tumors (unspecified), leukemia (myeloid), and solid tumors.
CYC116Advanced solid tumors
AlisertibFor the treatment of various forms of cancer.
MKC-1Investigated for use/treatment in breast cancer, leukemia (unspecified), lung cancer, and solid tumors.
SNS-314Investigated for use/treatment in solid tumors.
SeliciclibInvestigated for use/treatment in breast cancer, lung cancer, lymphoma (unspecified), multiple myeloma, leukemia (lymphoid), and cancer/tumors (unspecified).
SemaxanibInvestigated for use/treatment in colorectal cancer and lung cancer.
MidostaurinAn antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL).
TofacitinibA Janus kinase (JAK) inhibitor used to treat rheumatoid and psoriatic arthritis, and ulcerative colitis. It is not recommended to be combined with biologic therapies or potent immunosuppressants like cyclosporine or azathioprine.
OsimertinibA tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma.
AlectinibA kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
RabusertibRabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cancer, Pancreatic Neoplasms, and Non Small Cell Lung Cancer.
BarasertibBarasertib has been used in trials studying the treatment of Tumors, Lymphoma, Solid Tumors, Solid Tumours, and Myeloid Leukemia, among others.
SpebrutinibSpebrutinib has been used in trials studying the treatment of Rheumatoid Arthritis, Lymphoma, Large B-Cell, Diffuse, and Leukemia Lymphocytic Chronic B-Cell.
DanusertibDanusertib has been used in trials studying the treatment of Leukemia.
BafetinibBafetinib has been used in trials studying the treatment of Adult Gliosarcoma, Adult Mixed Glioma, Adult Glioblastoma, Chronic Myeloid Leukemia, and Acute Lymphocytic Leukemia, among others.
FlumatinibFlumatinib has been used in trials studying the treatment of Myelogenous Leukemia, Chronic.
VistusertibVistusertib is under investigation for the treatment of Advanced Gastric Adenocarcinoma.
OrantinibOrantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others.
LosmapimodLosmapimod has been investigated for the prevention of Chronic Obstructive Pulmonary Disease.
IndirubinIndirubin is under investigation in clinical trial NCT01735864 (Dosage Determination Trial for Indigo Naturalis Extract in Oil Ointment).
MerestinibMerestinib has been used in trials studying the treatment of Cancer, Solid Tumor, Advanced cancer, ColoRectal Cancer, and Metastatic Cancer, among others.
MK-5108MK-5108 has been used in trials studying the treatment of Cancer, Neoplasms, Tumors.
TAK-901TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others.
PF-03814735PF-03814735 has been used in trials studying the treatment of Solid Tumors.
SunitinibA receptor tyrosine kinase inhibitor and chemotherapeutic agent used for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST).
NilotinibA kinase inhibitor used for the chronic phase treatment of Chronic Myeloid Leukemia (CML) that is Philadelphia chromosome positive and for the treatment of CML that is resistant to therapy containing imatinib.
VandetanibAn antineoplastic kinase inhibitor used to treat symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.
RidaforolimusInvestigated for use/treatment in solid tumors, sarcoma, cancer/tumors (unspecified), endometrial cancer, prostate cancer, and bone metastases.
PazopanibAn antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy.
BosutinibAn antineoplastic agent used for the treatment of chronic, accelerated, or blast phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in adults with inadequate clinical response to other treatments.
CabozantinibA tyrosine kinase inhibitor used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer.
RuxolitinibA kinase inhibitor used to treat various types of myelofibrosis, polycythemia vera in patients who have not responded to or cannot tolerate hydroxyurea, and to treat graft-versus-host disease in cases that are refractory to steroid treatment.
VemurafenibA kinase inhibitor used to treat patients with Erdheim-Chester Disease who have the BRAF V600 mutation, and melanoma in patients who have the BRAF V600E mutation.
RegorafenibA kinase inhibitor used to treat patients with metastatic colorectal cancer, unresectable, locally advanced, or metastatic gastrointestinal stromal tumors, and hepatocellular carcinoma.
AfatinibAn antineoplastic agent used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy.
IbrutinibAn antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.
NintedanibA triple angiokinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and in combination with docetaxel for non-small cell lung cancer.
TivozanibTivozanib has been used in trials studying the treatment and basic science of Solid Tumors, Glioblastoma, Ovarian Cancer, Prostate Cancer, and Stage IV Disease, among others.
WortmanninWortmannin is a steroid metabolite of Penicillium funiculosum and Talaromyces wortmannii fungi. This drug acts as a nonspecific, covalent inhibitor of phosphoinositide 3-kinase enzymes (PI3Ks).
EverolimusA mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
MangostinMangostin is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
SirolimusAn immunosuppressant used to prevent organ transplant rejections and to treat lymphangioleiomyomatosis.
EmodinEmodin has been investigated for the treatment of Polycystic Kidney.
FasudilFasudil has been investigated in Carotid Stenosis.
MLN8054MLN8054 has been used in trials studying the treatment of Colon Neoplasm, Breast Neoplasm, Bladder Neoplasm, Pancreatic Neoplasm, and Advanced Malignancies.
CobimetinibAn antineoplastic agent and selective inhibitor of the mitogen-activated extracellular kinase (MEK) pathway used to treat unresectable or metastatic melanoma.
EncorafenibA kinase inhibitor used to treat unresectable or metastatic melanoma with specific mutations.
RibociclibA kinase inhibitor used to treat HR+, HER2- advanced or metastatic breast cancer.
IcotinibIcotinib hydrochloride is a novel epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor, exhibits encouraging efficacy and tolerability in patients with advanced non-small-cell lung cancer (NSCLC) who failed previous chemotherapy.
NeratinibA protein kinase inhibitor used to treat breast cancer that over expresses the HER2 receptor.
RociletinibRociletinib has been used in trials studying the treatment and prevention of Nonsmall Cell Lung Cancer, Non-small Cell Lung Cancer, and Locally Advanced or Metastatic Non-small Cell Lung Cancer.
DacomitinibA medication used to treat non small cell lung cancer with EGFR exon 19 deletion of exon 21 L858R substitution.
BinimetinibA medication used to treat metastatic melanoma with specific mutations.
AbemaciclibA medication used to treat HR+ HER2- advanced or metastatic breast cancer.
LorlatinibAn anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
BrigatinibAn anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer.
OlmutinibFor use in treatment of metastatic T790M mutation positive non-small cell lung cancer .
PimasertibPimasertib is under investigation in clinical trial NCT01378377 (Combination Trial of Pimasertib (MSC1936369B) With Temsirolimus).
RO-5126766 free baseRO-5126766 free base is under investigation in clinical trial NCT03875820 (Phase I Trial of VS-6063 and RO5126766.).
PelitinibInvestigated for use/treatment in colorectal cancer and lung cancer.
MotesanibInvestigated for use/treatment in solid tumors.
AV-412Investigated for use/treatment in cancer/tumors (unspecified).
IlorasertibIlorasertib has been used in trials studying the treatment of Myelodysplasia, Solid Neoplasm, Advanced Cancers, Advanced Solid Tumors, and Acute Myelogenous Leukemia, among others.
MomelotinibMomelotinib has been used in trials studying the treatment of Polycythemia Vera, Primary Myelofibrosis, Post-Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis (PMF), among others.
GSK-2636771GSK2636771 has been used in trials studying the treatment of CANCER, LYMPHOMA, Solid Neoplasm, Recurrent Solid Neoplasm, and Advanced Malignant Neoplasm, among others.
GedatolisibGedatolisib has been used in trials studying the basic science and treatment of Neoplasm, Ovary Cancer, Breast Cancer, Advanced Cancer, and Endometrial Cancer, among others.
TesevatinibTesevatinib has been used in trials studying the treatment of Cancer, Stomach Cancer, Brain Metastases, Esophageal Cancer, and Leptomeningeal Metastases, among others. Tesevatinib is a potent inhibitor of multiple RTKs...
EntrectinibEntrectinib is indicated for the treatment of metastatic ROS1-positive non-small cell lung cancer in adults. Entrectinib is also indicated in adults and children over 12 years old for the treatment...
NaquotinibNaquotinib has been used in trials studying the treatment of Solid Tumors, Non-small Cell Lung Cancer, Non-Small-Cell Lung Cancer (NSCLC), Epidermal Growth Factor Receptor Mutations, and Epidermal Growth Factor Receptor...
RigosertibRigosertib has been used in trials studying the treatment and basic science of MDS, RAEB, Cancer, Hepatoma, and Neoplasms, among others.
RimacalibRimacalib has been used in trials studying the treatment of Rheumatoid Arthritis (RA).
RebastinibRebastinib has been used in trials studying the treatment of Chronic Myeloid Leukemia. It is an inhibitor of Tie2 tyrosine kinase receptor and an antineoplastic agent.
AZD-0424AZD0424 has been used in trials studying the treatment of Advanced Solid Tumours.
X-396X-396 has been used in trials studying the treatment of Advanced Solid Tumors and Non-small Cell Lung Cancer.
RivoceranibRivoceranib is under investigation in clinical trial NCT02726854 (Apatinib as Second-line Treatment of Advanced Pancreatic Cancer).
EnsartinibEnsartinib is under investigation in clinical trial NCT03420508 (Treating Patients With Melanoma and ALK Alterations With Ensartinib).
PF-06700841PF-06700841 is under investigation in clinical trial NCT03236493 (Safety and Pharmacokinetic Study of PF-06700841 in Japanese Healthy Volunteers).
ZanubrutinibA kinase inhibitor used to treat mantle cell lymphoma, a type of B-cell non-Hodgkin lymphoma, in adults who previously received therapy.
UpadacitinibAn oral Janus kinase (JAK)1-selective inhibitor used in the treatment of moderate to severe rheumatoid arthritis in adult patients who did not respond well to methotrexate.
VoruciclibVoruciclib is under investigation in clinical trial NCT03547115 (A Phase 1 Study of Voruciclib in Subjects With B-Cell Malignancies or AML).
AbivertinibAbivertinib is a tyrosine kinase inhibitor targeted against mutant forms of both human epidermal growth factor receptor (EGFR) and Bruton's tyrosine kinase (BTK). It has been investigated for use in...
AvapritinibA selective tyrosine kinase inhibitor being investigated for the treatment of multidrug resistant gastrointestinal tumors.
H-89Not Available
DoramapimodDoramapimod is a P38 MAP kinase inhibitor.
AKI-001AKI-001 is an aurora kinase inhibitor.
ReversineNot Available
DorsomorphinNot Available
AZD-8330Investigated for use/treatment in cancer/tumors (unspecified).
(Rp)-cAMPSNot Available
RipretinibA kinase inhibitor used to treat advanced gastrointestinal stromal tumor (GIST).
AcalabrutinibA Bruton tyrosine kinase inhibitor used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma.
GilteritinibAn AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia.
FedratinibFedratinib is indicated to treat adults with primary or secondary myelofibrosis that is either intermediate-2 or high risk.
QuizartinibQuizartinib is under investigation in Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies. It is a potent inhibitor of FLT3.
LarotrectinibA kinase inhibitor used to treat solid tumors with neurotrophic receptor tyrosine kinase gene fusion, are metastatic, high risk for surgery, or have no alternative treatments.
Drugs & Drug Targets
DrugTargetType
GefitinibEpidermal growth factor receptortarget
GefitinibCytochrome P450 3A4enzyme
GefitinibCytochrome P450 2D6enzyme
GefitinibP-glycoprotein 1transporter
GefitinibATP-binding cassette sub-family G member 2transporter
GefitinibCytochrome P450 3A5enzyme
GefitinibCytochrome P450 1A1enzyme
GefitinibCytochrome P450 2C9enzyme
GefitinibCytochrome P450 2C19enzyme
GefitinibSerum albumincarrier
GefitinibAlpha-1-acid glycoprotein 1carrier
SorafenibSerine/threonine-protein kinase B-raftarget
SorafenibReceptor-type tyrosine-protein kinase FLT3target
SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
SorafenibVascular endothelial growth factor receptor 3target
SorafenibPlatelet-derived growth factor receptor betatarget
SorafenibMast/stem cell growth factor receptor Kittarget
SorafenibVascular endothelial growth factor receptor 2target
SorafenibCytochrome P450 3A4enzyme
SorafenibUDP-glucuronosyltransferase 1-9enzyme
SorafenibCytochrome P450 2B6enzyme
SorafenibCytochrome P450 2C8enzyme
SorafenibCytochrome P450 3A5enzyme
SorafenibCytochrome P450 3A7enzyme
SorafenibCytochrome P450 2C9enzyme
SorafenibMultidrug resistance-associated protein 4transporter
SorafenibP-glycoprotein 1transporter
SorafenibCanalicular multispecific organic anion transporter 1transporter
SorafenibATP-binding cassette sub-family G member 2transporter
SorafenibCytochrome P450 1A2enzyme
SorafenibCytochrome P450 2C19enzyme
SorafenibCytochrome P450 2D6enzyme
SorafenibUDP-glucuronosyltransferase 1-1enzyme
SorafenibRalA-binding protein 1transporter
SorafenibFibroblast growth factor receptor 1target
SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
SorafenibVascular endothelial growth factor receptor 1target
SorafenibSolute carrier organic anion transporter family member 1B1transporter
ErlotinibEpidermal growth factor receptortarget
ErlotinibCytochrome P450 3A4enzyme
ErlotinibATP-binding cassette sub-family G member 2transporter
ErlotinibP-glycoprotein 1transporter
ErlotinibNuclear receptor subfamily 1 group I member 2target
ErlotinibCytochrome P450 3A5enzyme
ErlotinibCytochrome P450 1A1enzyme
ErlotinibCytochrome P450 1A2enzyme
ErlotinibCytochrome P450 1B1enzyme
ErlotinibCytochrome P450 2D6enzyme
ErlotinibCytochrome P450 2C8enzyme
ErlotinibUDP-glucuronosyltransferase 1-1enzyme
ErlotinibSerum albumincarrier
ErlotinibAlpha-1-acid glycoprotein 1carrier
ErlotinibSolute carrier organic anion transporter family member 2B1transporter
ImatinibPlatelet-derived growth factor receptor betatarget
ImatinibTyrosine-protein kinase ABL1target
ImatinibMast/stem cell growth factor receptor Kittarget
ImatinibRET proto-oncogenetarget
ImatinibHigh affinity nerve growth factor receptortarget
ImatinibMacrophage colony-stimulating factor 1 receptortarget
ImatinibPlatelet-derived growth factor receptor alphatarget
ImatinibEpithelial discoidin domain-containing receptor 1target
ImatinibCytochrome P450 3A4enzyme
ImatinibBreakpoint cluster region proteintarget
ImatinibCytochrome P450 1A2enzyme
ImatinibCytochrome P450 2D6enzyme
ImatinibCytochrome P450 2C9enzyme
ImatinibCytochrome P450 2C19enzyme
ImatinibCytochrome P450 3A5enzyme
ImatinibCytochrome P450 3A7enzyme
ImatinibSolute carrier family 22 member 1transporter
ImatinibP-glycoprotein 1transporter
ImatinibSolute carrier family 22 member 2transporter
ImatinibATP-binding cassette sub-family G member 2transporter
ImatinibATP-binding cassette sub-family A member 3transporter
ImatinibProstaglandin G/H synthase 1enzyme
ImatinibSerum albumincarrier
ImatinibAlpha-1-acid glycoprotein 1carrier
ImatinibBile salt export pumptransporter
ImatinibCytochrome P450 2C8enzyme
DasatinibTyrosine-protein kinase ABL1target
DasatinibAbelson tyrosine-protein kinase 2target
DasatinibProto-oncogene tyrosine-protein kinase Srctarget
DasatinibTyrosine-protein kinase Fyntarget
DasatinibTyrosine-protein kinase Lcktarget
DasatinibTyrosine-protein kinase Yestarget
DasatinibMast/stem cell growth factor receptor Kittarget
DasatinibPlatelet-derived growth factor receptor betatarget
DasatinibEphrin type-A receptor 2target
DasatinibSignal transducer and activator of transcription 5Btarget
DasatinibCytochrome P450 3A4enzyme
DasatinibP-glycoprotein 1transporter
DasatinibATP-binding cassette sub-family G member 2transporter
DasatinibCytochrome P450 1A1enzyme
DasatinibCytochrome P450 1A2enzyme
DasatinibCytochrome P450 1B1enzyme
DasatinibCytochrome P450 3A5enzyme
DasatinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DasatinibTyrosine-protein kinase BTKtarget
DasatinibNuclear receptor subfamily 4 group A member 3target
DasatinibBreakpoint cluster region proteintarget
DasatinibTyrosine-protein kinase CSKtarget
DasatinibEphrin type-A receptor 5target
DasatinibEphrin type-B receptor 4target
DasatinibTyrosine-protein kinase Fgrtarget
DasatinibTyrosine-protein kinase FRKtarget
DasatinibHeat shock cognate 71 kDa proteintarget
DasatinibTyrosine-protein kinase Lyntarget
DasatinibMitogen-activated protein kinase kinase kinase MLTtarget
DasatinibMitogen-activated protein kinase 14target
DasatinibAmidophosphoribosyltransferasetarget
LapatinibEpidermal growth factor receptortarget
LapatinibReceptor tyrosine-protein kinase erbB-2target
LapatinibCytochrome P450 3A4enzyme
LapatinibCytochrome P450 2C8enzyme
LapatinibP-glycoprotein 1transporter
LapatinibAntigen peptide transporter 1transporter
LapatinibCytochrome P450 3A5enzyme
LapatinibCytochrome P450 2C19enzyme
TemsirolimusSerine/threonine-protein kinase mTORtarget
TemsirolimusCytochrome P450 3A4enzyme
TemsirolimusCytochrome P450 3A5enzyme
TemsirolimusCytochrome P450 3A7enzyme
TemsirolimusCytochrome P450 2D6enzyme
TemsirolimusP-glycoprotein 1transporter
AxitinibVascular endothelial growth factor receptor 1target
AxitinibVascular endothelial growth factor receptor 2target
AxitinibVascular endothelial growth factor receptor 3target
AxitinibCytochrome P450 3A4enzyme
AxitinibCytochrome P450 3A5enzyme
AxitinibCytochrome P450 1A2enzyme
AxitinibCytochrome P450 2C19enzyme
AxitinibUDP-glucuronosyltransferase 1-1enzyme
AxitinibP-glycoprotein 1transporter
AxitinibSolute carrier organic anion transporter family member 1B1transporter
CrizotinibCytochrome P450 3A4enzyme
CrizotinibCytochrome P450 3A5enzyme
CrizotinibP-glycoprotein 1transporter
CrizotinibALK tyrosine kinase receptortarget
CrizotinibHepatocyte growth factor receptortarget
CrizotinibCytochrome P450 2B6enzyme
CrizotinibCytochrome P450 3A Subfamilyenzyme
PonatinibTyrosine-protein kinase ABL1target
PonatinibBreakpoint cluster region proteintarget
PonatinibMast/stem cell growth factor receptor Kittarget
PonatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
PonatinibAngiopoietin-1 receptortarget
PonatinibReceptor-type tyrosine-protein kinase FLT3target
PonatinibCytochrome P450 3A4enzyme
PonatinibCytochrome P450 2C8enzyme
PonatinibCytochrome P450 2D6enzyme
PonatinibCytochrome P450 3A5enzyme
PonatinibP-glycoprotein 1transporter
PonatinibATP-binding cassette sub-family G member 2transporter
PonatinibFibroblast growth factor receptor 1target
PonatinibFibroblast growth factor receptor 2target
PonatinibFibroblast growth factor receptor 3target
PonatinibFibroblast growth factor receptor 4target
PonatinibTyrosine-protein kinase Lcktarget
PonatinibProto-oncogene tyrosine-protein kinase Srctarget
PonatinibTyrosine-protein kinase Lyntarget
PonatinibVascular endothelial growth factor receptor 2target
PonatinibPlatelet-derived growth factor receptor alphatarget
TrametinibCytochrome P450 2C8enzyme
TrametinibCytochrome P450 3A4enzyme
TrametinibDual specificity mitogen-activated protein kinase kinase 1target
TrametinibDual specificity mitogen-activated protein kinase kinase 2target
DabrafenibCytochrome P450 3A4enzyme
DabrafenibCytochrome P450 2C8enzyme
DabrafenibP-glycoprotein 1transporter
DabrafenibATP-binding cassette sub-family G member 2transporter
DabrafenibSolute carrier organic anion transporter family member 1B1transporter
DabrafenibSolute carrier organic anion transporter family member 1B3transporter
DabrafenibSolute carrier family 22 member 6transporter
DabrafenibSolute carrier family 22 member 8transporter
DabrafenibSerine/threonine-protein kinase B-raftarget
DabrafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DabrafenibSerine/threonine-protein kinase SIK1target
DabrafenibSerine/threonine-protein kinase Nek11target
DabrafenibLIM domain kinase 1target
DabrafenibCytochrome P450 2B6enzyme
DabrafenibCytochrome P450 2C9enzyme
CeritinibALK tyrosine kinase receptortarget
CeritinibP-glycoprotein 1transporter
CeritinibCytochrome P450 2C9enzyme
CeritinibCytochrome P450 3A4enzyme
PalbociclibCyclin-dependent kinase 4target
PalbociclibCyclin-dependent kinase 6target
PalbociclibCytochrome P450 3A4enzyme
PalbociclibBile salt sulfotransferaseenzyme
PalbociclibP-glycoprotein 1transporter
PalbociclibATP-binding cassette sub-family G member 2transporter
PalbociclibSerum albumincarrier
PalbociclibSolute carrier family 22 member 1transporter
LenvatinibVascular endothelial growth factor receptor 1target
LenvatinibVascular endothelial growth factor receptor 2target
LenvatinibVascular endothelial growth factor receptor 3target
LenvatinibFibroblast growth factor receptor 1target
LenvatinibFibroblast growth factor receptor 2target
LenvatinibFibroblast growth factor receptor 3target
LenvatinibFibroblast growth factor receptor 4target
LenvatinibPlatelet-derived growth factor receptor alphatarget
LenvatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
LenvatinibMast/stem cell growth factor receptor Kittarget
LenvatinibP-glycoprotein 1transporter
LenvatinibATP-binding cassette sub-family G member 2transporter
LenvatinibCytochrome P450 3A4enzyme
LenvatinibAldehyde oxidaseenzyme
LenvatinibCytochrome P450 2C8enzyme
LenvatinibCytochrome P450 2C9enzyme
LenvatinibCytochrome P450 1A2enzyme
LenvatinibCytochrome P450 2B6enzyme
LenvatinibCytochrome P450 2C19enzyme
LenvatinibSolute carrier family 22 member 6transporter
LenvatinibSolute carrier family 22 member 8transporter
LenvatinibSolute carrier family 22 member 2transporter
LenvatinibSolute carrier organic anion transporter family member 1B1transporter
LenvatinibBile salt export pumptransporter
LenvatinibCytochrome P450 2D6enzyme
CediranibVascular endothelial growth factor receptor 2target
GenisteinEstrogen receptor betatarget
GenisteinDNA topoisomerase 2-alphatarget
GenisteinProtein-tyrosine kinase 2-betatarget
GenisteinP-glycoprotein 1transporter
GenisteinMultidrug resistance-associated protein 1transporter
GenisteinATP-binding cassette sub-family G member 2transporter
GenisteinCytochrome P450 1A2enzyme
GenisteinNuclear receptor coactivator 1target
GenisteinEstrogen receptor alphatarget
GenisteinNuclear receptor coactivator 2target
GenisteinTransthyretincarrier
GenisteinSteroid hormone receptor ERR2target
GenisteinSteroid hormone receptor ERR1target
GenisteinNuclear receptor subfamily 1 group I member 2target
GenisteinRAC-alpha serine/threonine-protein kinasetarget
GenisteinG-protein coupled estrogen receptor 1target
GenisteinCytochrome P450 1B1target
GenisteinSex hormone-binding globulintarget
GenisteinCytochrome P450 1A1enzyme
GenisteinSolute carrier organic anion transporter family member 1B1transporter
GenisteinSolute carrier organic anion transporter family member 2B1transporter
GenisteinCytochrome P450 2C8enzyme
GenisteinCytochrome P450 2C9enzyme
GenisteinCytochrome P450 3A1enzyme
GenisteinCytochrome P450 3A2enzyme
GenisteinCytochrome P450 3A4enzyme
7-Hydroxystaurosporine3-phosphoinositide-dependent protein kinase 1target
AlvocidibGlycogen phosphorylase, muscle formtarget
AlvocidibCyclin-dependent kinase 7target
AlvocidibCyclin-dependent kinase 5target
AlvocidibCyclin-dependent kinase 9target
AlvocidibCyclin-dependent kinase 1target
AlvocidibCyclin-dependent kinase 6target
AlvocidibEpidermal growth factor receptortarget
AlvocidibCyclin-dependent kinase 4target
AlvocidibCyclin-dependent kinase 8target
AlvocidibCyclin-dependent kinase 2target
AlvocidibATP-binding cassette sub-family G member 2transporter
AlvocidibGlycogen phosphorylase, brain formtarget
AlvocidibGlycogen phosphorylase, liver formtarget
AlvocidibUDP-glucuronosyltransferase 1-1enzyme
VatalanibVascular endothelial growth factor receptor 1target
VatalanibVascular endothelial growth factor receptor 2target
VatalanibVascular endothelial growth factor receptor 3target
AT9283Aurora kinase Atarget
AT9283Aurora kinase Btarget
CYC116Aurora kinase Atarget
CYC116Vascular endothelial growth factor receptor 2target
AlisertibAurora kinase Atarget
SNS-314Aurora kinase Atarget
SNS-314Aurora kinase Ctarget
SeliciclibCyclin-dependent kinase 1target
SeliciclibCyclin-dependent kinase 2target
SeliciclibMitogen-activated protein kinase 3target
SeliciclibMitogen-activated protein kinase 1target
SeliciclibCyclin-dependent kinase 7target
SeliciclibCyclin-dependent kinase 9target
SeliciclibCasein kinase I isoform epsilontarget
SeliciclibProstaglandin G/H synthase 2enzyme
SemaxanibVascular endothelial growth factor receptor 2target
SemaxanibProstaglandin G/H synthase 2enzyme
MidostaurinProtein kinase C alpha typetarget
MidostaurinVascular endothelial growth factor receptor 2target
MidostaurinMast/stem cell growth factor receptor Kittarget
MidostaurinPlatelet-derived growth factor receptor alphatarget
MidostaurinPlatelet-derived growth factor receptor betatarget
MidostaurinReceptor-type tyrosine-protein kinase FLT3target
MidostaurinCytochrome P450 3A Subfamilyenzyme
MidostaurinCytochrome P450 1A2enzyme
MidostaurinCytochrome P450 2B6enzyme
MidostaurinCytochrome P450 2C8enzyme
MidostaurinCytochrome P450 2C9enzyme
MidostaurinCytochrome P450 2C19enzyme
MidostaurinCytochrome P450 2D6enzyme
MidostaurinCytochrome P450 2E1enzyme
MidostaurinCytochrome P450 3A4enzyme
MidostaurinCytochrome P450 3A5enzyme
MidostaurinCytochrome P450 3A7enzyme
MidostaurinCytochrome P450 3A43enzyme
TofacitinibNon-receptor tyrosine-protein kinase TYK2target
TofacitinibCytochrome P450 3A4enzyme
TofacitinibCytochrome P450 2C19enzyme
TofacitinibTyrosine-protein kinase JAK2target
TofacitinibTyrosine-protein kinase JAK1target
TofacitinibTyrosine-protein kinase JAK3target
TofacitinibSerum albumincarrier
OsimertinibEpidermal growth factor receptortarget
OsimertinibP-glycoprotein 1transporter
OsimertinibATP-binding cassette sub-family G member 2transporter
OsimertinibCytochrome P450 3A4enzyme
OsimertinibCytochrome P450 1A2enzyme
AlectinibALK tyrosine kinase receptortarget
AlectinibATP-binding cassette sub-family G member 2transporter
AlectinibP-glycoprotein 1transporter
IndirubinCytochrome P450 1A1target
IndirubinAryl hydrocarbon receptortarget
SunitinibPlatelet-derived growth factor receptor betatarget
SunitinibVascular endothelial growth factor receptor 1target
SunitinibVascular endothelial growth factor receptor 2target
SunitinibVascular endothelial growth factor receptor 3target
SunitinibMast/stem cell growth factor receptor Kittarget
SunitinibReceptor-type tyrosine-protein kinase FLT3target
SunitinibMacrophage colony-stimulating factor 1 receptortarget
SunitinibPlatelet-derived growth factor receptor alphatarget
SunitinibCytochrome P450 3A4enzyme
SunitinibCytochrome P450 3A5enzyme
SunitinibCytochrome P450 3A7enzyme
SunitinibMultidrug resistance-associated protein 4transporter
SunitinibP-glycoprotein 1transporter
SunitinibCanalicular multispecific organic anion transporter 1transporter
SunitinibATP-binding cassette sub-family G member 2transporter
NilotinibTyrosine-protein kinase ABL1target
NilotinibMast/stem cell growth factor receptor Kittarget
NilotinibCytochrome P450 2D6enzyme
NilotinibCytochrome P450 2C8enzyme
NilotinibCytochrome P450 2C9enzyme
NilotinibCytochrome P450 3A4enzyme
NilotinibP-glycoprotein 1transporter
NilotinibATP-binding cassette sub-family G member 2transporter
NilotinibUDP-glucuronosyltransferase 1-1transporter
NilotinibCytochrome P450 2B6enzyme
NilotinibSolute carrier organic anion transporter family member 1B1transporter
VandetanibVascular endothelial growth factor Atarget
VandetanibEpidermal growth factor receptortarget
VandetanibMultidrug resistance-associated protein 1transporter
VandetanibATP-binding cassette sub-family G member 2transporter
VandetanibProto-oncogene tyrosine-protein kinase receptor Rettarget
VandetanibDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
VandetanibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
VandetanibProtein-tyrosine kinase 6target
VandetanibAngiopoietin-1 receptortarget
VandetanibAlpha-1-acid glycoprotein 1carrier
VandetanibSerum albumincarrier
VandetanibCytochrome P450 3A4enzyme
VandetanibSolute carrier family 22 member 2transporter
VandetanibP-glycoprotein 1transporter
RidaforolimusSerine/threonine-protein kinase mTORtarget
RidaforolimusCytochrome P450 3A4enzyme
PazopanibVascular endothelial growth factor receptor 1target
PazopanibVascular endothelial growth factor receptor 2target
PazopanibVascular endothelial growth factor receptor 3target
PazopanibPlatelet-derived growth factor receptor alphatarget
PazopanibPlatelet-derived growth factor receptor betatarget
PazopanibMast/stem cell growth factor receptor Kittarget
PazopanibCytochrome P450 3A4enzyme
PazopanibCytochrome P450 2D6enzyme
PazopanibCytochrome P450 2C8enzyme
PazopanibCytochrome P450 1A2enzyme
PazopanibP-glycoprotein 1transporter
PazopanibATP-binding cassette sub-family G member 2transporter
PazopanibSolute carrier organic anion transporter family member 1B1transporter
PazopanibUDP-glucuronosyltransferase 1-1transporter
PazopanibFibroblast growth factor receptor 3target
PazopanibTyrosine-protein kinase ITK/TSKtarget
PazopanibFibroblast growth factor 1target
PazopanibSH2B adapter protein 3target
BosutinibBreakpoint cluster region proteintarget
BosutinibTyrosine-protein kinase ABL1target
BosutinibTyrosine-protein kinase Lyntarget
BosutinibTyrosine-protein kinase HCKtarget
BosutinibProto-oncogene tyrosine-protein kinase Srctarget
BosutinibP-glycoprotein 1transporter
BosutinibCytochrome P450 3A4enzyme
BosutinibCyclin-dependent kinase 2target
BosutinibDual specificity mitogen-activated protein kinase kinase 1target
BosutinibDual specificity mitogen-activated protein kinase kinase 2target
BosutinibMitogen-activated protein kinase kinase kinase 2target
BosutinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
BosutinibCytochrome P450 2C8enzyme
CabozantinibCytochrome P450 3A4enzyme
CabozantinibCytochrome P450 2C9enzyme
CabozantinibHepatocyte growth factor receptortarget
CabozantinibVascular endothelial growth factor receptor 2target
CabozantinibProto-oncogene tyrosine-protein kinase receptor Rettarget
CabozantinibCytochrome P450 2C8enzyme
RuxolitinibTyrosine-protein kinase JAK1target
RuxolitinibTyrosine-protein kinase JAK2target
RuxolitinibCytochrome P450 3A4enzyme
VemurafenibSerum albumincarrier
VemurafenibAlpha-1-acid glycoprotein 1carrier
VemurafenibCytochrome P450 1A2enzyme
VemurafenibCytochrome P450 2D6enzyme
VemurafenibCytochrome P450 3A4enzyme
VemurafenibSerine/threonine-protein kinase B-raftarget
VemurafenibMultidrug resistance-associated protein 1transporter
VemurafenibATP-binding cassette sub-family G member 2transporter
VemurafenibCytochrome P450 2C9enzyme
VemurafenibCytochrome P450 2C8enzyme
VemurafenibCytochrome P450 2B6enzyme
VemurafenibP-glycoprotein 1transporter
RegorafenibCytochrome P450 3A4enzyme
RegorafenibUDP-glucuronosyltransferase 1-9enzyme
RegorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
RegorafenibVascular endothelial growth factor receptor 1target
RegorafenibVascular endothelial growth factor receptor 2target
RegorafenibVascular endothelial growth factor receptor 3target
RegorafenibMast/stem cell growth factor receptor Kittarget
RegorafenibPlatelet-derived growth factor receptor alphatarget
RegorafenibPlatelet-derived growth factor receptor betatarget
RegorafenibFibroblast growth factor receptor 1target
RegorafenibFibroblast growth factor receptor 2target
RegorafenibAngiopoietin-1 receptortarget
RegorafenibDiscoidin domain-containing receptor 2target
RegorafenibHigh affinity nerve growth factor receptortarget
RegorafenibEphrin type-A receptor 2target
RegorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
RegorafenibSerine/threonine-protein kinase B-raftarget
RegorafenibCytochrome P450 2C8enzyme
RegorafenibCytochrome P450 2C9enzyme
RegorafenibCytochrome P450 2B6enzyme
RegorafenibMitogen-activated protein kinase 11target
RegorafenibTyrosine-protein kinase FRKtarget
RegorafenibTyrosine-protein kinase ABL1target
RegorafenibP-glycoprotein 1transporter
RegorafenibATP-binding cassette sub-family G member 2transporter
RegorafenibUDP-glucuronosyltransferase 1-1enzyme
AfatinibEpidermal growth factor receptortarget
AfatinibReceptor tyrosine-protein kinase erbB-2target
AfatinibReceptor tyrosine-protein kinase erbB-4target
AfatinibP-glycoprotein 1transporter
AfatinibATP-binding cassette sub-family G member 2transporter
IbrutinibTyrosine-protein kinase BTKtarget
IbrutinibCytochrome P450 3A4enzyme
IbrutinibCytochrome P450 3A5enzyme
IbrutinibSerum albumincarrier
Ibrutinibalpha1-acid glycoproteincarrier
IbrutinibCytochrome P450 2D6enzyme
NintedanibVascular endothelial growth factor receptor 1target
NintedanibVascular endothelial growth factor receptor 2target
NintedanibVascular endothelial growth factor receptor 3target
NintedanibPlatelet-derived growth factor receptor alphatarget
NintedanibPlatelet-derived growth factor receptor betatarget
NintedanibFibroblast growth factor receptor 1target
NintedanibFibroblast growth factor receptor 2target
NintedanibFibroblast growth factor receptor 3target
NintedanibReceptor-type tyrosine-protein kinase FLT3target
NintedanibTyrosine-protein kinase Lcktarget
NintedanibTyrosine-protein kinase Lyntarget
NintedanibProto-oncogene tyrosine-protein kinase Srctarget
NintedanibP-glycoprotein 1transporter
NintedanibCytochrome P450 3A4enzyme
NintedanibSolute carrier family 22 member 1transporter
NintedanibSerum albumincarrier
NintedanibUDP-glucuronosyltransferase 1-1enzyme
NintedanibUDP-glucuronosyltransferase 1-7enzyme
NintedanibUDP-glucuronosyltransferase 1-8enzyme
NintedanibUDP-glucuronosyltransferase 1-10enzyme
NintedanibATP-binding cassette sub-family G member 2transporter
WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
WortmanninSerine/threonine-protein kinase PLK1target
WortmanninPhosphatidylinositol 3-kinase regulatory subunit alphatarget
WortmanninPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
EverolimusSerine/threonine-protein kinase mTORtarget
EverolimusCytochrome P450 3A4enzyme
EverolimusSolute carrier organic anion transporter family member 1B1transporter
EverolimusSolute carrier organic anion transporter family member 1B3transporter
EverolimusSolute carrier organic anion transporter family member 1A2transporter
EverolimusCytochrome P450 2D6enzyme
EverolimusP-glycoprotein 1transporter
SirolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
SirolimusCytochrome P450 3A4enzyme
SirolimusSerine/threonine-protein kinase mTORtarget
SirolimusFibroblast growth factor 2target
SirolimusCytochrome P450 3A5enzyme
SirolimusCytochrome P450 3A7enzyme
SirolimusP-glycoprotein 1transporter
SirolimusSolute carrier organic anion transporter family member 1B1transporter
SirolimusMultidrug and toxin extrusion protein 1transporter
EmodinCasein kinase II subunit alphatarget
EmodinPutative ketoacyl reductasetarget
Emodin3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZtarget
EmodinAryl hydrocarbon receptortarget
FasudilcAMP-dependent protein kinase inhibitor alphatarget
FasudilcAMP-dependent protein kinase catalytic subunit alphatarget
FasudilRho-associated protein kinase 1target
FasudilRho-associated protein kinase 2target
MLN8054Aurora kinase Atarget
CobimetinibDual specificity mitogen-activated protein kinase kinase 1target
CobimetinibCytochrome P450 3A4enzyme
CobimetinibP-glycoprotein 1enzyme
CobimetinibSolute carrier organic anion transporter family member 1B1transporter
CobimetinibSolute carrier organic anion transporter family member 1B3transporter
CobimetinibATP-binding cassette sub-family G member 2transporter
CobimetinibP-glycoprotein 1transporter
EncorafenibCytochrome P450 3A4enzyme
EncorafenibCytochrome P450 2C19enzyme
EncorafenibCytochrome P450 2D6enzyme
EncorafenibSerine/threonine-protein kinase B-raftarget
EncorafenibG1/S-specific cyclin-D1target
RibociclibCyclin-dependent kinase 4target
RibociclibCyclin-dependent kinase 6target
RibociclibCytochrome P450 3A4enzyme
IcotinibEpidermal growth factor receptortarget
IcotinibCytochrome P450 3A4enzyme
IcotinibCytochrome P450 1A2enzyme
IcotinibCytochrome P450 3A5enzyme
NeratinibCytochrome P450 3A4enzyme
NeratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
NeratinibP-glycoprotein 1transporter
NeratinibEpidermal growth factor receptortarget
NeratinibSerum albumincarrier
Neratinibalpha1-acid glycoproteincarrier
DacomitinibCytochrome P450 2D6enzyme
DacomitinibSerum albumincarrier
DacomitinibCytochrome P450 3A4enzyme
DacomitinibCytochrome P450 2C9enzyme
DacomitinibUDP-glucuronosyltransferase 1-1enzyme
DacomitinibP-glycoprotein 1transporter
DacomitinibATP-binding cassette sub-family G member 2transporter
DacomitinibSolute carrier family 22 member 1transporter
DacomitinibEpidermal growth factor receptortarget
BinimetinibInterleukin-6target
BinimetinibTumor necrosis factortarget
BinimetinibInterleukin-1 betatarget
BinimetinibUDP-glucuronosyltransferase 1-1enzyme
BinimetinibCytochrome P450 1A2enzyme
BinimetinibCytochrome P450 2C19enzyme
BinimetinibMitogen-activated protein kinase kinase kinase 1target
BinimetinibDual specificity mitogen-activated protein kinase kinase 2target
AbemaciclibMultidrug and toxin extrusion protein 1transporter
AbemaciclibMultidrug and toxin extrusion protein 2transporter
AbemaciclibCyclin-dependent kinase 4target
AbemaciclibCyclin-dependent kinase 6target
AbemaciclibSerum albumincarrier
Abemaciclibalpha1-acid glycoproteincarrier
AbemaciclibCytochrome P450 3A4enzyme
AbemaciclibP-glycoprotein 1transporter
AbemaciclibATP-binding cassette sub-family G member 2transporter
AbemaciclibSolute carrier family 22 member 2transporter
AbemaciclibCytochrome P450 1A2enzyme
AbemaciclibCytochrome P450 2B6enzyme
AbemaciclibCytochrome P450 2C8enzyme
AbemaciclibCytochrome P450 2C9enzyme
AbemaciclibCytochrome P450 2D6enzyme
LorlatinibALK tyrosine kinase receptortarget
LorlatinibCytochrome P450 3A Subfamilyenzyme
LorlatinibCytochrome P450 3A5enzyme
LorlatinibCytochrome P450 2B6enzyme
LorlatinibCytochrome P450 2C8enzyme
LorlatinibCytochrome P450 2C19enzyme
LorlatinibUDP-glucuronosyltransferase 1-3enzyme
BrigatinibALK tyrosine kinase receptortarget
BrigatinibEpidermal growth factor receptortarget
BrigatinibTyrosine-protein kinase ABL1target
BrigatinibInsulin-like growth factor 1 receptortarget
BrigatinibReceptor-type tyrosine-protein kinase FLT3target
BrigatinibCytochrome P450 2C8enzyme
BrigatinibCytochrome P450 3A4enzyme
BrigatinibInsulin receptortarget
BrigatinibHepatocyte growth factor receptortarget
BrigatinibReceptor tyrosine-protein kinase erbB-4target
BrigatinibReceptor tyrosine-protein kinase erbB-2target
BrigatinibATP-binding cassette sub-family B member 5transporter
BrigatinibATP-binding cassette sub-family G member 2transporter
BrigatinibSolute carrier family 22 member 1transporter
BrigatinibMultidrug and toxin extrusion protein 1transporter
BrigatinibMultidrug and toxin extrusion protein 2transporter
BrigatinibCytochrome P450 3A Subfamilyenzyme
OlmutinibEpidermal growth factor receptortarget
PelitinibEpidermal growth factor receptortarget
AV-412Epidermal growth factor receptortarget
AV-412Receptor tyrosine-protein kinase erbB-2target
TesevatinibPro-epidermal growth factortarget
TesevatinibEphrin type-B receptor 4target
TesevatinibReceptor tyrosine-protein kinase erbB-2target
EntrectinibCytochrome P450 3A4enzyme
EntrectinibP-glycoprotein 1transporter
EntrectinibHigh affinity nerve growth factor receptortarget
EntrectinibBDNF/NT-3 growth factors receptortarget
EntrectinibNT-3 growth factor receptortarget
EntrectinibProto-oncogene tyrosine-protein kinase ROStarget
EntrectinibTyrosine-protein kinase JAK2target
EntrectinibActivated CDC42 kinase 1target
ZanubrutinibCytochrome P450 3A4enzyme
ZanubrutinibP-glycoprotein 1transporter
ZanubrutinibCytochrome P450 2B6enzyme
ZanubrutinibTyrosine-protein kinase BTKtarget
ZanubrutinibEpidermal growth factor receptortarget
ZanubrutinibReceptor tyrosine-protein kinase erbB-2target
ZanubrutinibReceptor tyrosine-protein kinase erbB-4target
ZanubrutinibTyrosine-protein kinase ITK/TSKtarget
ZanubrutinibCytoplasmic tyrosine-protein kinase BMXtarget
ZanubrutinibTyrosine-protein kinase JAK2target
ZanubrutinibTyrosine-protein kinase Tectarget
ZanubrutinibTyrosine-protein kinase Blktarget
ZanubrutinibTyrosine-protein kinase JAK3target
ZanubrutinibProtein-tyrosine kinase 6target
ZanubrutinibTyrosine-protein kinase Fgrtarget
ZanubrutinibTyrosine-protein kinase FRKtarget
ZanubrutinibTyrosine-protein kinase Lcktarget
ZanubrutinibTyrosine-protein kinase TXKtarget
ZanubrutinibCytochrome P450 3A Subfamilyenzyme
UpadacitinibTyrosine-protein kinase JAK1target
UpadacitinibCytochrome P450 3A4enzyme
UpadacitinibCytochrome P450 2D6enzyme
UpadacitinibP-glycoprotein 1transporter
UpadacitinibATP-binding cassette sub-family G member 2transporter
UpadacitinibSolute carrier organic anion transporter family member 1B1transporter
AbivertinibEpidermal growth factor receptortarget
AbivertinibTyrosine-protein kinase BTKtarget
AvapritinibPlatelet derived growth factor receptor alphatarget
AvapritinibMast/stem cell growth factor receptor Kittarget
AvapritinibP-glycoprotein 1transporter
AvapritinibATP-binding cassette sub-family G member 2transporter
AvapritinibCytochrome P450 3A4enzyme
AvapritinibCytochrome P450 2C9enzyme
H-89cAMP-dependent protein kinase catalytic subunit alphatarget
H-89cAMP-dependent protein kinase inhibitor alphatarget
H-89Serine/threonine-protein kinase haspintarget
DoramapimodMitogen-activated protein kinase 14target
AKI-001Aurora kinase Atarget
ReversineAurora kinase Btarget
ReversineInner centromere proteintarget
DorsomorphinActivin receptor type-1target
DorsomorphinPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
AZD-8330Mitogen-activated protein kinase kinase kinase 1target
(Rp)-cAMPScAMP-dependent protein kinase type I-alpha regulatory subunittarget
RipretinibMast/stem cell growth factor receptor Kittarget
RipretinibPlatelet-derived growth factor receptor betatarget
RipretinibAngiopoietin-1 receptortarget
RipretinibVascular endothelial growth factor receptor 2target
RipretinibSerine/threonine-protein kinase B-raftarget
RipretinibPlatelet-derived growth factor receptor alphatarget
RipretinibCytochrome P450 2C8enzyme
RipretinibMast/stem cell growth factor receptor Kitenzyme
RipretinibPlatelet-derived growth factor receptor alphaenzyme
RipretinibSerum albumincarrier
Ripretinibalpha1-acid glycoproteincarrier
RipretinibP-glycoprotein 1transporter
RipretinibATP-binding cassette sub-family G member 2transporter
RipretinibMultidrug and toxin extrusion protein 1transporter
RipretinibCytochrome P450 3A4enzyme
RipretinibCytochrome P450 2D6enzyme
RipretinibCytochrome P450 2E1enzyme
AcalabrutinibTyrosine-protein kinase BTKtarget
AcalabrutinibCytochrome P450 3A4enzyme
AcalabrutinibCytochrome P450 3A5enzyme
AcalabrutinibCytochrome P450 3A Subfamilyenzyme
AcalabrutinibSerum albumincarrier
Acalabrutinibalpha1-acid glycoproteincarrier
GilteritinibSerum albumincarrier
GilteritinibCytochrome P450 3A4enzyme
GilteritinibReceptor-type tyrosine-protein kinase FLT3target
GilteritinibSerotonin Receptorstarget
GilteritinibP-glycoprotein 1transporter
GilteritinibMultidrug and toxin extrusion protein 1transporter
GilteritinibATP-binding cassette sub-family G member 2transporter
GilteritinibSolute carrier family 22 member 1transporter
GilteritinibTyrosine-protein kinase receptor UFOtarget
GilteritinibALK tyrosine kinase receptortarget
FedratinibP-glycoprotein 1transporter
FedratinibATP-binding cassette sub-family G member 2transporter
FedratinibSolute carrier organic anion transporter family member 1B1transporter
FedratinibSolute carrier organic anion transporter family member 1B3transporter
FedratinibPOU domain, class 2, transcription factor 2transporter
FedratinibMultidrug and toxin extrusion protein 1transporter
FedratinibMultidrug and toxin extrusion protein 2transporter
FedratinibCytochrome P450 3A4enzyme
FedratinibCytochrome P450 2C19enzyme
FedratinibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
FedratinibTyrosine-protein kinase JAK2target
FedratinibReceptor-type tyrosine-protein kinase FLT3target
FedratinibTyrosine-protein kinase JAK1target
FedratinibCytochrome P450 2D6enzyme
QuizartinibReceptor-type tyrosine-protein kinase FLT3target
LarotrectinibCytochrome P450 3A4enzyme
LarotrectinibHigh affinity nerve growth factor receptortarget
LarotrectinibBDNF/NT-3 growth factors receptortarget
LarotrectinibNT-3 growth factor receptortarget
LarotrectinibP-glycoprotein 1transporter
LarotrectinibATP-binding cassette sub-family G member 2transporter