Amino Acids, Branched-Chain

Name
Amino Acids, Branched-Chain
Accession Number
DBCAT000344
Description

Amino acids which have a branched carbon chain.

Drugs
DrugDrug Description
LeucineAn amino acid commonly found as a component of total parenteral nutrition.
ValineAn amino acid commonly found as a component of total parenteral nutrition.
IsoleucineAn amino acid commonly found as a component of total parenteral nutrition.
ValaciclovirAn guanine nucleoside antiviral used to treat herpes exacerbations.
L-alloisoleucineNot Available
2-aminoisobutyric acidNot Available
FaldaprevirFaldaprevir has been investigated for the treatment of Chronic Hepatitis C.
VoxilaprevirA nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections.
GlecaprevirA Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C.
PromazineA phenothiazine used to manage schizophrenia.
Leucine Phosphonic AcidNot Available
Beta-HydroxyleucineNot Available
UbenimexAn adjuvant therapy used for acute and chronic myelonous leukemia, lung cancer and nasopharyngeal cancer. It is also used to treat hypercholesterolaemia.
NorvalineA drug used to treat vaginal inflammation with betamethasone and tyrothricin.
RupintrivirInvestigated for use/treatment in viral infection.
PPI-2458Investigated for use/treatment in lymphoma (non-hodgkin's) and solid tumors.
DaclatasvirA direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.
SacubitrilA neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.
OmbitasvirA direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections.
ValbenazineA vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia.
VaniprevirVaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C...
NirogacestatNirogacestat has been used in trials studying the treatment of Breast Cancer, HIV Infection, Desmoid Tumors, Advanced Solid Tumors, and Aggressive Fibromatosis, among others.
ORE-1001ORE1001 has been used in trials studying the treatment of Mild to Moderate Ulcerative Colitis. It is an ACE2 inhibitor.
DecernotinibDecernotinib has been used in trials studying the treatment of Drug Interactions and Rheumatoid Arthritis.
AcetylleucineUsed for treating vestibular-related imbalance and vertigo.
NarlaprevirNot Annotated
BMS-817399BMS-817399 is under investigation in clinical trial NCT01404585 (Proof-of-Concept Study With BMS-817399 to Treat Moderate to Severe Rheumatoid Arthritis).
RavidasvirRavidasvir is under investigation in clinical trial NCT02961426 (Sofosbuvir Plus Ravidasvir for the Treatment of HCV Chronic Infection).
GC-376 free acidGC-376 is a 3C-like protease (3CLpro or Mpro) inhibitor that stops the cleavage and activation of functional viral proteins required for replication and transcription in host cells . The compound...
PF-07304814PF-07304814 is a small molecule prodrug that targets the 3CLpro protease (Mpro), which is used by viruses like SARS-CoV-2 to assemble and multiply . Once administered through intravenous infusion, the...
NirmatrelvirAn oral protease inhibitor with emergency use authorization for the treatment of mild-to-moderate COVID-19.
Drugs & Drug Targets
DrugTargetType
LeucineProbable leucine--tRNA ligase, mitochondrialtarget
LeucineLeucine carboxyl methyltransferase 2target
LeucineLeucine carboxyl methyltransferase 1target
LeucineLeucine--tRNA ligase, cytoplasmictarget
LeucineBranched-chain-amino-acid aminotransferase, mitochondrialtarget
LeucineBranched-chain-amino-acid aminotransferase, cytosolictarget
LeucineMonocarboxylate transporter 10transporter
LeucineMonocarboxylate transporter 8transporter
ValinePropionyl-CoA carboxylase beta chain, mitochondrialtarget
ValineBranched-chain-amino-acid aminotransferase, cytosolictarget
ValineValine--tRNA ligasetarget
ValineMonocarboxylate transporter 10transporter
ValineValine--tRNA ligaseenzyme
ValinePropionyl-CoA carboxylase beta chain, mitochondrialenzyme
ValineBranched-chain-amino-acid aminotransferase, cytosolicenzyme
IsoleucineShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
IsoleucineBranched-chain-amino-acid aminotransferase, cytosolictarget
IsoleucineBranched-chain-amino-acid aminotransferase, mitochondrialtarget
IsoleucineIsoleucine--tRNA ligase, cytoplasmictarget
IsoleucineIsoleucine--tRNA ligase, mitochondrialtarget
IsoleucineMonocarboxylate transporter 10transporter
ValaciclovirThymidine kinasetarget
ValaciclovirDNA polymerase catalytic subunittarget
ValaciclovirSolute carrier family 15 member 1transporter
ValaciclovirSolute carrier family 15 member 2transporter
ValaciclovirSolute carrier family 22 member 8transporter
ValaciclovirSolute carrier family 22 member 6transporter
ValaciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
ValaciclovirIleal sodium/bile acid cotransportertransporter
ValaciclovirGuanylate kinaseenzyme
ValaciclovirThymidine kinaseenzyme
2-aminoisobutyric acidCorticoliberintarget
2-aminoisobutyric acidPro-neuropeptide Ytarget
2-aminoisobutyric acidMonocarboxylate transporter 10transporter
VoxilaprevirCytochrome P450 3A4enzyme
VoxilaprevirCytochrome P450 1A2enzyme
VoxilaprevirCytochrome P450 2C8enzyme
VoxilaprevirNS3/4A proteintarget
VoxilaprevirP-glycoprotein 1transporter
VoxilaprevirATP-binding cassette sub-family G member 2transporter
VoxilaprevirSolute carrier organic anion transporter family member 1B1transporter
VoxilaprevirSolute carrier organic anion transporter family member 1B3transporter
GlecaprevirCytochrome P450 3A Subfamilyenzyme
GlecaprevirUDP-glucuronosyltransferase 1-1enzyme
GlecaprevirP-glycoprotein 1transporter
GlecaprevirATP-binding cassette sub-family G member 2transporter
GlecaprevirSolute carrier organic anion transporter family member 1B1transporter
GlecaprevirSolute carrier organic anion transporter family member 1B3transporter
GlecaprevirNS3 proteasetarget
GlecaprevirCytochrome P450 3A4enzyme
PromazineDopamine D2 receptortarget
Promazine5-hydroxytryptamine receptor 2Atarget
Promazine5-hydroxytryptamine receptor 2Ctarget
PromazineAlpha-1A adrenergic receptortarget
PromazineMuscarinic acetylcholine receptor M1target
PromazineHistamine H1 receptortarget
PromazineCytochrome P450 2C19enzyme
PromazineCytochrome P450 1A2enzyme
PromazineCytochrome P450 3A4enzyme
PromazineCytochrome P450 2C9enzyme
PromazineCytochrome P450 2D6enzyme
Leucine Phosphonic AcidBacterial leucyl aminopeptidasetarget
Leucine Phosphonic AcidCytosol aminopeptidasetarget
UbenimexBacterial leucyl aminopeptidasetarget
UbenimexLeukotriene A-4 hydrolasetarget
UbenimexSolute carrier family 15 member 1transporter
UbenimexSolute carrier family 15 member 2transporter
UbenimexDipeptidase 1enzyme
NorvalineGlycine amidinotransferase, mitochondrialtarget
NorvalineOrnithine carbamoyltransferase, mitochondrialtarget
RupintrivirGenome polyproteintarget
PPI-2458Methionine aminopeptidase 2target
DaclatasvirNonstructural protein 5Atarget
DaclatasvirCytochrome P450 3A5enzyme
DaclatasvirCytochrome P450 3A4enzyme
DaclatasvirCytochrome P450 3A43enzyme
DaclatasvirCytochrome P450 3A7enzyme
DaclatasvirP-glycoprotein 1transporter
DaclatasvirSolute carrier organic anion transporter family member 1B1transporter
DaclatasvirSolute carrier organic anion transporter family member 1B3transporter
DaclatasvirATP-binding cassette sub-family G member 2transporter
SacubitrilNeprilysintarget
SacubitrilSolute carrier organic anion transporter family member 1B1transporter
SacubitrilSolute carrier organic anion transporter family member 1B3transporter
OmbitasvirNonstructural protein 5Atarget
OmbitasvirCytochrome P450 2C8enzyme
OmbitasvirP-glycoprotein 1transporter
OmbitasvirATP-binding cassette sub-family G member 2transporter
OmbitasvirUDP-glucuronosyltransferase 1-1enzyme
Valbenazinevesicular monoamine transporter 2 (VMAT2)target
ValbenazineCytochrome P450 2D6enzyme
ValbenazineCytochrome P450 3A4enzyme
ValbenazineCytochrome P450 3A5enzyme
ORE-1001Carboxypeptidase N catalytic chaintarget
ORE-1001Carboxypeptidase N subunit 2target
GC-376 free acidReplicase polyprotein 1abtarget
GC-376 free acidReplicase polyprotein 1atarget
GC-376 free acidReplicase polyprotein 1abtarget
GC-376 free acidReplicase polyprotein 1atarget
GC-376 free acidReplicase polyprotein 1abtarget
PF-07304814Replicase polyprotein 1abtarget
NirmatrelvirReplicase polyprotein 1abtarget
NirmatrelvirCytochrome P450 3A4enzyme
NirmatrelvirP-glycoprotein 1transporter