GLPG-0492

DB12461InvestigationalSmall molecule

Glpg0492 is under investigation in clinical trial NCT01130818 (First-in-Human Single Ascending Dose of GLPG0492).

Chemical structure of GLPG-0492
Mechanism
Curator reviewed
Formula / weight
C19H14F3N3O3 · 389.334 g/mol (avg)
Code names
(-)-GLPG-0492

Resolves to

Compound
UNII8O59X1ACZTCAS1215085-92-9ChEMBLCHEMBL2178100PubChem59317190
Structure
InChIKeyVAJGULUVTFDTAS-GOSISDBHSA-NSMILESCN1C(=O)N(C(=O)[C@@]1(CO)C1=CC=CC=C1)C1=CC=C(C#N)C(=C1)C(F)(F)F
Targets
P10275AR

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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170Drug interactionsStructured to mechanism, not free text
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3Clinical trialsPhase, status and sponsor resolved per trial
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3+ReferencesStructured and connected to the statements they support
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Which drugs share a target with GLPG-0492, and which of those have an active Phase 3 trial?

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