- Accession Number
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Drug Drug Description Biotin A B-complex vitamin found in many multivitamin products. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Clotrimazole A topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis. Olmesartan An angiotensin receptor blocker (ARB) used in the treatment of hypertension. Etomidate A short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures. Carbimazole A drug used for the reduction of thyroid function. Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. Mephenytoin A phenylhydantoin used to treat refractory partial epilepsy. Clonidine An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. Dexmedetomidine An alpha-2 agonist used for sedation during various procedures. Nilutamide An antineoplastic hormone used to treat prostate cancer. Losartan An angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. Phentolamine An alpha adrenergic antagonist used to reverse soft tissue anesthesia. Tizanidine An alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity. Ethotoin A hydantoin antiepileptic used to control tonic-clonic and complex partial seizures. Methimazole A thionamide antithyroid agent that inhibits the actions of thyroid peroxidase, leading to a reduction in thyroid hormone synthesis and amelioration of hyperthyroidism. Tolazoline A vasodilator used to treat pulmonary artery anomalies. Levamisole Levamisole is a nicotinic receptor agonist used to treat helminth infections and some skin infections. Dacarbazine An antineoplastic agent used to treat malignant melanoma and Hodgkin's disease. Temozolomide An alkylating agent used to treat glioblastoma multiforme and refractory anaplastic astrocytoma. Vardenafil A phosphodiesterase 5 inhibitor used to treat erectile dysfunction. Ondansetron A serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively. Tinidazole A nitroimidazole used to treat trichomoniasis, giardiasis, amebiasis, and bacterial vaginosis. Metronidazole A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections. Oxymetazoline An alpha-1A adrenoceptor agonist used to treat nasal congestion, allergic reactions of the eye, and facial erythema associated with rosacea. Apraclonidine An alpha adrenergic agonist used to treat raised intraocular pressure. Miconazole An azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis. Trimethaphan For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies. Econazole A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor. Dantrolene A direct-acting skeletal muscle relaxant used for the treatment of management of the fulminant hypermetabolism of skeletal muscle leading to malignant hyperthermia crisis. Fosphenytoin An antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. AICA ribonucleotide 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate and analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has... trans-urocanic acid Not Available Fidarestat Not Available Sorbinil Not Available 2-Iminobiotin Not Available Histidinol Not Available N-acetylhistamine Not Available Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Enoximone A selective phosphodiesterase inhibitor indicated in the short term treatment of congestive heart failure. Acadesine Investigated for use/treatment in cardiac reperfusion injury, cardiovascular disorders, and coronary artery disease. Lofexidine A centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults. Azimilide Investigated for use/treatment in arrhythmia and atrial fibrillation. Pretomanid Part of a three-drug regimen used for the treatment of extensively drug-resistant and multidrug-resistant pulmonary tuberculosis. OMS-103HP Investigated for use/treatment in inflammatory disorders (unspecified), knee replacement, orthopedic surgery, and pain (acute or chronic). Histamine An ingredient of topical drugs for the relief of joint pain or muscle aches and pains. Evofosfamide Investigated for use/treatment in solid tumors. Aviptadil Not Annotated Naphazoline A sympathomimetic vasoconstrictor used for the symptomatic relief of redness and itching of the eye, and nasal congestion. Antazoline An antihistamine agent used for the symptomatic treatment of nasal congestion and allergic conjunctivitis. Enzalutamide An androgen receptor inhibitor used to treat castration-resistant prostate cancer. Isoconazole An imidazole antifungal used for superficial skin and vaginal infections. Allantoin An ingredient used in skin care products to relieve irritation and protect minor cuts, scrapes, and burns. Medetomidine Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist.... Delamanid An antibiotic used to treat multidrug resistant tuberculosis. Misonidazole Misonidazole is under investigation in clinical trial NCT00038038 (Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole). Imidapril An ACE inhibitor used in the treatment of essential hypertension. Creatinine Creatinine has been used in trials studying the treatment of Amyotrophic Lateral Sclerosis. Benznidazole A trypanocidal agent used to treat Chagas disease. Nimorazole Nimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others. Fexinidazole An orally bioavailable 2-substituted 5-nitroimidazole used to treat early- and late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense. GLPG-0492 Glpg0492 is under investigation in clinical trial NCT01130818 (First-in-Human Single Ascending Dose of GLPG0492). Pimonidazole Pimonidazole is under investigation for the diagnostic of Prostate Cancer and Head and Neck Cancer. Idazoxan Idazoxan has been used in trials studying the basic science of Molecular Imaging, Alzheimer Disease, and Major Depressive Disorder. Etanidazole Etanidazole has been used in trials studying the diagnostic of Adult Ependymoma, Malignant Ascites, Adult Gliosarcoma, Adult Mixed Glioma, and Adult Glioblastoma, among others. Secnidazole A nitroimidazole antibiotic used to treat bacterial vaginosis. Ornidazole A nitroimidazole agent indicated in the treatment of infections such as trichomoniasis, amebiasis, and giardiasis. Azanidazole Not Annotated Flutrimazole A topical antifungal used to treat pityriasis capitis and seborrheic dermatitis. Tolonidine Not Annotated Clodantoin Not Annotated Niridazole Not Annotated Morinidazole Morinidazole is under investigation in clinical trial NCT03380793 (A Trial to Assess the Efficacy and Safety of Morinidazole in Patients With Appendicitis). Fluoroazomycin arabinoside F-18 Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer). Zoledronic acid A bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors. Apalutamide An androgen receptor inhibitor used to treat non metastatic, castration resistant prostate cancer. PCO-371 PCO-371 is under investigation in clinical trial NCT02475616 (A Single Ascending Dose Study of PCO371 in Healthy Volunteers). Dethiobiotin Not Available Rilematovir Rilematovir is under investigation in clinical trial NCT04056611 (Effects of JNJ-53718678 in Adult and Adolescent Participants Who Had a Hematopoietic Stem Cell Transplantation and Who Are Infected With Respiratory Syncytial... Metronidazole benzoate Not Annotated Tetramisole An anthelmintic indicated to treat hookworm infections. Aminoimidazole carboxamide Investigated for use/treatment in allergic rhinitis and pediatric indications.
- Drugs & Drug Targets